Effectiveness of Intravenous Metoclopramide Prophylaxis on the Reduction of Intraoperative and Early Postoperative Nausea and Vomiting after Emergency Caesarean Section under Spinal Anaesthesia

Endalew, Endalew Nigussie Simeneh; Gebremedhn, Endale Gebreegziabher; Gebreegzi, Amare Hailekros; Kassahun, Habtamu Getinet; Kassa, Adugna Aregawi; Abebe, Tamrat Befekadu

doi:10.4172/2155-6148.1000809

Cited by 5 publications

(12 citation statements)

References 23 publications

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“…Spinal anesthesia (SA) recently has gained popularity for cesarean section due to the change of attitude secondary to an increased awareness for the safety of regional block for both mother and newborns [ [1] , [2] , [3] , [4] ]. The extremely small dose of local anesthetic used nearly eliminates the possibility of a systemic toxic reaction and will not cross the placenta to any appreciable degree compared with epidural anesthesia [ 3 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, this problem arises even more often in cesarean operations under SA. The incidence of intraoperative nausea and vomiting (IONV) is as high as 80% [ 4 ] This condition is affected by factors that are particular to the patient, anesthesia, and surgery. Prediction of IONV is important for enabling appropriate and timely use of antiemetics [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Magnitude and associated factors of intraoperative nausea and vomiting among parturients who gave birth with cesarean section under spinal anesthesia at South Gondar zone Hospitals, Ethiopia

Chekol

Zewudu

Eshetie

et al. 2021

Annals of Medicine &Amp; Surgery

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Background Intraoperative nausea and vomiting are common intraoperative events by which parturient feel discomfort and disturbed after spinal anesthesia. Methods Hospital-based cross-sectional study was conducted on mothers who underwent cesarean section with spinal anesthesia. Descriptive analysis and chi-square test were employed. Bivariable and multivariable logistic regressions were used to measure the association of factors with the outcome variable intraoperative nausea and vomiting. A p-value of ≤0.05 was used to decide statistical significance for multivariable logistic regression. Result A total of 246 parturients were participated in this study. The incidence of intraoperative nausea and vomiting was 40.2%. According to multivariable logistic regression, age greater than 30 years (AOR, 6.26; 95%CI, 2.2–17.78; p-value 0.001), primiparous (AOR, 3.72; 95%CI, 1.35–10.24; p-value, 0.011), having motion sickness (AOR, 7.1; 95%CI, 2.75–18.33; p-value 0.001), emergency cesarean sectin (AOR, 9.85; 95%CI, 3.19–30.38; p-value 0.001), oxygen suplimentation (AOR, 0.021; 95%CI, 0.005–0.08; p-value 0.0001) and uterotonic agent (AOR, 2.99; 95%CI 1.24–7.22; p-value 0.015) had statistically significant association with intraoperative nausea and vomiting. Conclusion In our study, the overall incidence of intraoperative nausea and vomiting after spinal anesthesia was 40.2%. Parturients with age greater than 30 years, having motion sickness, didn't get intraoperative supplemental oxygen, oxytocin used for the uterotonic purpose, emergency surgery, and primiparous were at increased risk of intraoperative nausea and vomiting.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Magnitude and associated factors of intraoperative nausea and vomiting among parturients who gave birth with cesarean section under spinal anesthesia at South Gondar zone Hospitals, Ethiopia

Chekol

Zewudu

Eshetie

et al. 2021

Annals of Medicine &Amp; Surgery

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show abstract

“…Spinal anesthesia recently has gained popularity for cesarean section due to the change of attitude secondary to an increased awareness for the safety of regional block for both mother and newborns (1)(2)(3)(4). The extremely small dose of local anesthetic used nearly eliminates the possibility of a systemic toxic reaction and will not cross the placenta to any appreciable degree compared with epidural anesthesia (3,5).…”

Section: Introductionmentioning

confidence: 99%

“…The stimulating factors of the vomiting mechanism can be stimulation of the vagal nerves, cerebral cortex, vestibular body, and the chemoreceptors trigger zone. The receptors of dopamine, serotonin, histamine, and muscarinic play a role in this process (4,8).…”

Section: Introductionmentioning

confidence: 99%

“…Increased intragastric pressure due to gravid utres, hypotension, sretching the peritoneum (exteriorization of the uterus), excessive surgical manipulation and visceral stimulation, using opioids, using uterotonic agents, visceral type of pain, and the patient's mental status play a role and place the patient at high risk for IONV (3,9,10). Hypotension associated with spinal,epidural, and spinal-epidural (combined) anaesthesia is a particularly important contributing factor for IONV (4,7,11).…”

Section: Introductionmentioning

confidence: 99%

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Magnitude And Associated Factors of Intraoperative Nausea And Vomiting Among parturients who gave birth with Cesarean Section under Spinal Anesthesia At Hospitals in South Gondar Zone, Ethiopia

Chekol¹,

Zewudu²,

Eshetie³

et al. 2021

Preprint

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Background Intraoperative nausea and vomiting is common intraoperative conditions by which parturient feel discomfort and disturbed after spinal anesthesia. Methods Hospital based cross-sectional study was conducted on mothers underwent cesarean section with spinal anesthesia. Descriptive analysis and chi square test were employed. Bivariable and multivariable logistic regression were used to measure the association of factors with the outcome variable intraoperative nausea and vomiting. A p-value of ≤ 0.05 was used to decide statistical significance for multivariable logistic regression. Result A total of 246 parturients were participated in this study. The incidence of intraoperative nausea and vomiting was 40.2%. According to multivariable logistic regression, age greater than 30 years (AOR, 6.26; 95%CI, 2.2-17.78; p-value 0.001), primiparous ( AOR, 3.72; 95%CI, 1.35–10.24; p-value, 0.011), having motion sickness (AOR, 7.1; 95%CI, 2.75–18.33; p-value 0.001), emergency cesarean sectin (AOR, 9.85; 95%CI, 3.19–30.38; p-value 0.001), oxygen suplimentation (AOR, 0.021; 95%CI, 0.005–0.08; p-value 0.0001) and uterotonic agent (AOR, 2.99; 95%CI 1.24–7.22; p-value 0.015) had statistically significant association with intraoperative nausea and vomiting. Conclusion In our study, the overall incidence of intraoperative nausea and vomiting after spinal anesthesia was 40.2%. Parturients with age greater than 30 years, having motion sickness, didn’t got intraoperative supplemental oxygen, oxytocin used for uterotonic purpose, emergency surgery and primiparous were at increased risk intraoperative nausea and vomiting.

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Ultrasonographic assessment of metoclopramide effect on gastric volume in parturients females undergoing Caesarean section: a randomized double blind study

et al. 2023

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Effectiveness of Intravenous Metoclopramide Prophylaxis on the Reduction of Intraoperative and Early Postoperative Nausea and Vomiting after Emergency Caesarean Section under Spinal Anaesthesia

Cited by 5 publications

References 23 publications

Magnitude and associated factors of intraoperative nausea and vomiting among parturients who gave birth with cesarean section under spinal anesthesia at South Gondar zone Hospitals, Ethiopia

Magnitude and associated factors of intraoperative nausea and vomiting among parturients who gave birth with cesarean section under spinal anesthesia at South Gondar zone Hospitals, Ethiopia

Magnitude And Associated Factors of Intraoperative Nausea And Vomiting Among parturients who gave birth with Cesarean Section under Spinal Anesthesia At Hospitals in South Gondar Zone, Ethiopia

Ultrasonographic assessment of metoclopramide effect on gastric volume in parturients females undergoing Caesarean section: a randomized double blind study

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