Effectiveness of Intralesional Triamcinolone in the Treatment of Keloids in Children

Acosta, Silvana; Ureta, Ester; Yáñez, R.; Oliva, Natalia; Searle, Susana; Guerra, Carolina

doi:10.1111/pde.12746

Cited by 20 publications

(17 citation statements)

References 14 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of other studies support a multimodal approach . Acosta and colleagues found that intralesional triamcinolone acetonide was highly effective as a single‐modality treatment for pediatric keloids . Newer treatment modalities such as pulsed dye laser, fractional ablative lasers and 5‐fluorouracil with or without topical steroids have shown promising results in keloid management .…”

Section: Discussionmentioning

confidence: 99%

“…The only significant variable associated with recurrence in our study was the size of the keloid. In some studies, keloids on the trunk and extremities and those undergoing multimodal treatment have been associated with recurrence, whereas others have found no relationship between treatment outcome and keloid location, duration of the keloid, or etiology …”

Section: Discussionmentioning

confidence: 99%

“…7,[9][10][11] Acosta and colleagues found that intralesional triamcinolone acetonide was highly effective as a single-modality treatment for pediatric keloids. 12 Newer treatment modalities such as pulsed dye laser, fractional ablative lasers and 5-fluorouracil with or without topical steroids have shown promising results in keloid management. 13 In our subjects, although there was no standardized protocol, larger keloids generally underwent multimodal therapy.…”

Section: Treatment and Treatment Outcomesmentioning

confidence: 99%

See 2 more Smart Citations

Pediatric keloids: A 6‐year retrospective review

Michael

Ademola

Olawoye

et al. 2017

Pediatric Dermatology

View full text Add to dashboard Cite

Background/Objectives Keloids are reportedly rare at the extremes of life. We sought to describe the epidemiology of pediatric keloids seen at the plastic surgery outpatient department of the University College Hospital, Ibadan. Methods We retrospectively reviewed all children younger than 19 years who presented with nonburn keloids between 2008 and 2014. Data were obtained on age; duration, size, and location of the keloid; family history; mode of treatment; and outcome. Outcome variables were recurrence and wound complications. Data were analyzed using the Pearson chi‐square test for discreet variables and the independent‐sample t test for continuous variables. P < .05 was taken as statistically significant. Results Within the review period, 304 patients presented with keloids, of whom 40 (13.1%) were younger than 19 years. There was a female preponderance (n = 23, 57.5%). The mean age at onset of the keloid was 9.3 years (range 3 months‐18 years). Thirty (75%) patients had keloids in the head and neck region. Keloids were sporadic in 31 (77.5%) patients. Nineteen (47.5%) patients had multimodal treatment for keloid. The recurrence rate was 20%. Recurrence was significantly associated with the size of the lesion (P = .003). Conclusion Keloids during childhood are not rare. More attention should be paid to the management of keloids in this age group.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Treatment and Treatment Outcomesmentioning

confidence: 99%

See 1 more Smart Citation

Pediatric keloids: A 6‐year retrospective review

Michael

Ademola

Olawoye

et al. 2017

Pediatric Dermatology

View full text Add to dashboard Cite

show abstract

“…A prospective clinical trial in 21 children also showed that monthly intralesional TAC infiltration (20 mg/cm 3 , ≤40 mg/session) for 3 months decreased the average size of the 25 keloids by 82.7%. Only one keloid did not respond to treatment, even after five infiltrations . The side effects of intralesional steroid administration are mainly pain, hypopigmentation, hyperpigmentation, skin atrophy, and telangiectasia…”

Section: Current and Emerging Pharmaceuticals In Clinical Keloid Manamentioning

confidence: 95%

“…Only one keloid did not respond to treatment, even after five infiltrations. 43 The side effects of intralesional steroid administration are mainly pain, hypopigmentation, hyperpigmentation, skin atrophy, and telangiectasia. 41 The therapeutic effects of BTA are conflicting and not convincing.…”

Section: Pharmaceutical Therapies Targeting the Prolonged Inflammatmentioning

confidence: 99%

Managing keloid scars: From radiation therapy to actual and potential drug deliveries

Huang

Liu

You

et al. 2019

International Wound Journal

View full text Add to dashboard Cite

The aetiology of keloids is becoming clearer, but many questions remain, including about the most optimal treatment. Current therapies include surgical excision, radiotherapy, and various pharmaceutical drugs. However, none of these drugs are keloid‐specific. Moreover, all current interventions are associated with high recurrence rates. Here, we review the pharmaceutical interventions that are currently available. All are based on the fact that keloids are an expanding solid mass with intense chronic inflammation at its advancing edges. Consequently, current pharmaceuticals aim to reduce the mass and/or symptoms of keloids, similar to surgery and radiotherapy. They include chemotherapies, immunotherapies, volume‐reducing therapies, and anti‐inflammatory therapies. We also describe new advances in keloid pharmaceuticals. They include drugs that were designed to treat systemic diseases such as hypertension or breast cancer but were found to also treat keloids. Furthermore, recent progress in genetic, epigenetic, and stem cell therapies suggests that they could become useful in the keloid field. This review of pharmaceutical advances will hopefully promote additional research and the development of effective and specific pharmaceuticals for keloids.

show abstract

A scoping review of the treatment of hypertrophic scars and keloids

Davies¹,

Carter²,

Brindley³

2022

Dermatological Reviews

View full text Add to dashboard Cite

Hypertrophic scars and keloids are both conditions that represent an abnormal healing response by skin in response to some form of trauma. They are a cause of significant morbidity and psychological distress to patients. The costs associated with treating these conditions are considerable and had already reached 12 billion US dollars per annum by 2009. The lack of a well‐established treatment to reliably and effectively treat these conditions is demonstrated by the multitude of different treatments available. This scoping review aimed to review the treatment landscape available for hypertrophic scars and keloids to provide an overview of this varied field. A total of 113 studies representing 5211 participants were located. We identified over 40 different treatments utilised in the treatment of established scars and prophylactically to prevent scarring of wounds and burns. The heterogeneity of study design in terms of control arms, comparators, and outcome measures means that direct comparison of studies across the identified studies is difficult. While a large number of interventions were shown to have a beneficial effect compared with no treatment, there was no clear treatment that was both sufficiently effective and useable to have achieved widespread usage. This study highlights the wide variety of treatments available for hypertrophic scars and keloids. Future work will concentrate on more specific questions which will lend themselves to more detailed investigation using techniques such as network meta‐analysis. Future studies of treatments for hypertrophic scars and keloids should also ensure they are designed to allow for easy comparison with other studies.

show abstract

Effectiveness of Intralesional Triamcinolone in the Treatment of Keloids in Children

Abstract: Triamcinolone acetonide is highly effective for the treatment of pediatric keloids. There is no relationship between clinical response and the factors evaluated, such as lesion location, etiology and age of the keloid.

Cited by 20 publications

References 14 publications

Pediatric keloids: A 6‐year retrospective review

Pediatric keloids: A 6‐year retrospective review

Managing keloid scars: From radiation therapy to actual and potential drug deliveries

A scoping review of the treatment of hypertrophic scars and keloids

Contact Info

Product

Resources

About