Effectiveness of Huai Qi Huang Granules on Juvenile Collagen-induced Arthritis and Its Influence on Pyroptosis Pathway in Synovial Tissue

He, Tingting; Xie, Xia; Zhang, Xinyan; Shen, Pan; Ling, Jiayun; Han, Yanxinli; Wen, Yue; Hu, Xiufen; Lü, Huiling

doi:10.1007/s11596-019-2106-3

Cited by 11 publications

(5 citation statements)

References 46 publications

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“…In contrast to the aforementioned agents, AC-YVad-CMK suppresses the levels of proinflammatory cytokines to promote the proliferation and differentiation of alveolar osteoblasts, ultimately alleviating periodontal disease [ 269 , 270 ]. Treatment with HQH effectively inhibited caspase-1-dependent pyroptosis to improve joint inflammation in juvenile collagen-induced arthritis in rats [ 271 ] (Fig. 10 ).…”

Section: Potential Targeted Treatment Strategies For Pyroptosismentioning

confidence: 99%

Role of pyroptosis in inflammation and cancer

et al. 2022

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Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of continuous cell expansion until the cytomembrane ruptures, resulting in the release of cellular contents that can activate strong inflammatory and immune responses. Pyroptosis, an innate immune response, can be triggered by the activation of inflammasomes by various influencing factors. Activation of these inflammasomes can induce the maturation of caspase-1 or caspase-4/5/11, both of which cleave gasdermin D to release its N-terminal domain, which can bind membrane lipids and perforate the cell membrane. Here, we review the latest advancements in research on the mechanisms of pyroptosis, newly discovered influencing factors, antitumoral properties, and applications in various diseases. Moreover, this review also provides updates on potential targeted therapies for inflammation and cancers, methods for clinical prevention, and finally challenges and future directions in the field.

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Section: Potential Targeted Treatment Strategies For Pyroptosismentioning

confidence: 99%

Role of pyroptosis in inflammation and cancer

et al. 2022

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“…Ethyl pyruvate markedly suppresses caspase11/GSDMD-mediated pyroptosis induced by LPS and bacterial outer membrane vesicles (OMVs) in macrophage and in the mouse cecal ligation and puncture peritonitis sepsis model, to effectively protect against lethal endotoxemia and rescue sepsis [61]. Huai Qi Huang consists of Chinese medicines of Huaier, Chinese wolfberry and polygonatum sibiricum, and it has been reported to suppress the caspase1/GDSMD-mediated pyroptosis pathway in the joint synovial tissues effectively, and then improve joints' inflammation of juvenile collagen-induced arthritis rats [63]. Andrographolide [64] and dendrobium alkaloids [65] are the active components respectively extracted from andrographis paniculate and Chinese herbal medicine dendrobium.…”

Section: Compounds Inhibiting Pyroptosis To Treat Inflammatory Diseasesmentioning

confidence: 99%

Mechanisms and Therapeutic Regulation of Pyroptosis in Inflammatory Diseases and Cancer

Zheng

2020

IJMS

139

111

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Programmed Cell Death (PCD) is considered to be a pathological form of cell death when mediated by an intracellular program and it balances cell death with survival of normal cells. Pyroptosis, a type of PCD, is induced by the inflammatory caspase cleavage of gasdermin D (GSDMD) and apoptotic caspase cleavage of gasdermin E (GSDME). This review aims to summarize the latest molecular mechanisms about pyroptosis mediated by pore-forming GSDMD and GSDME proteins that permeabilize plasma and mitochondrial membrane activating pyroptosis and apoptosis. We also discuss the potentiality of pyroptosis as a therapeutic target in human diseases. Blockade of pyroptosis by compounds can treat inflammatory disease and pyroptosis activation contributes to cancer therapy.

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“…Cell death is controlled partially by RCD pathways, which comprise apoptosis, necroptosis, ferroptosis, pyroptosis, etc. [53,[63][64][65][66][67][68][69][70][71][72]. Pyroptosis has been proved to be closely related to sepsis-induced organ damage, but whether inhibiting pyroptosis could be a possible therapy tactic for the brain in sepsis is starved for more evidence [73,74].…”

Section: Discussionmentioning

confidence: 99%

HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model

et al. 2023

Mediators of Inflammation

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Background. Sepsis, which could cause a systemic inflammatory response, is a life-threatening disease with a high morbidity and mortality rate. There is evidence that brain injury may be related to severe systemic infection induced by sepsis. The brain injury caused by sepsis could increase the risk of mortality in septic patients, which seriously affects the septic patient’s prognosis of survival. Although there remains a focus on sepsis research, clinical measures to prevent and treat brain injury in sepsis are not yet available, and the high mortality rate is still a big health burden. Therefore, it is necessary to investigate the new molecules or regulated pathways that can effectively inhibit the progress of sepsis. Objective. NLR family pyrin domain-containing 3 (NLRP3) increased in the procession of sepsis and functioned as the key regulator of pyroptosis. Heat shock factor 1 (HSF1) can protect organs from multiorgan dysfunction syndrome induced by lipopolysaccharides in mice, and NLRP3 could be inhibited by HSF1 in many organs. However, whether HSF1 regulated NLRP3 in sepsis-induced brain injury, as well as the detailed mechanism of HSF1 in brain injury, remains unknown in the sepsis model. In this research, we try to explore the relationship between HSF1 and NLRP3 in a sepsis model and try to reveal the mechanism of HSF1 inhibiting the process of brain injury. Methods. In this study, we used wild-type mice and hsf1-/- mice for in vivo research and PC12 cells for in vitro research. Real-time PCR and Western blot were used to analyze the expression of HSF1, NLRP3, cytokines, and pyrolytic proteins. EthD-III staining was chosen to detect the pyroptosis of the hippocampus and PC12 cells. Results. The results showed that HSF1 is negatively related to pyroptosis. The pyroptosis in cells of brain tissue was significantly increased in the hsf1-/- mouse model compared to hsf1+/+ mice. In PC12 cells, hsf1 siRNA can upregulate pyroptosis while HSF1-transfected plasmid could inhibit the pyroptosis. HSF1 could negatively regulate the NLRP3 pathway in PC12 cells, while hsf1 siRNA enhanced the pyroptosis in PC12 cells, which could be reversed by nlrp3 siRNA. Conclusion. These results imply that HSF1 could alleviate sepsis-induced brain injury by inhibiting pyroptosis through the NLRP3-dependent pathway in brain tissue and PC12 cells, suggesting HSF1 as a potential molecular target for treating brain injury in sepsis clinical studies.

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Effectiveness of Huai Qi Huang Granules on Juvenile Collagen-induced Arthritis and Its Influence on Pyroptosis Pathway in Synovial Tissue

Cited by 11 publications

References 46 publications

Role of pyroptosis in inflammation and cancer

Role of pyroptosis in inflammation and cancer

Mechanisms and Therapeutic Regulation of Pyroptosis in Inflammatory Diseases and Cancer

HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model

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