Effectiveness of different corticosterone administration methods to elevate corticosterone serum levels, induce depressive-like behavior, and affect neurogenesis levels in female rats

Kott, Jennifer; Mooney‐Leber, Sean M.; Shoubah, F.A.; Brummelte, Susanne

doi:10.1016/j.neuroscience.2015.11.006

Cited by 54 publications

(21 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, since the corticosterone elevations were not maintained throughout the study, the deficit we observed was due to a lasting effect produced by earlier hormone administration. Finally, our results, like those of others (Hermann et al, 2009; Kott et al, 2016), serve as a caveat for the importance of verifying actual blood levels following hormone pellet administration.…”

Section: 0 Corticosterone Effects On Eyeblink Trace Conditioningsupporting

confidence: 72%

Influence of postnatal glucocorticoids on hippocampal-dependent learning varies with elevation patterns and administration methods

Claflin

Schmidt

Vallandingham

et al. 2017

Neurobiology of Learning and Memory

View full text Add to dashboard Cite

Recent interest in the lasting effects of early-life stress has expanded to include effects on cognitive performance. An increase in circulating glucocorticoids is induced by stress exposure and glucocorticoid effects on the hippocampus likely underlie many of the cognitive consequences. Here we review studies showing that corticosterone administered to young rats at the conclusion of the stress-hyporesponsiveness period affects later performance in hippocampally-mediated trace eyeblink conditioning. The nature and even direction of these effects varies with the elevation patterns (level, duration, temporal fluctuation) achieved by different administration methods. We present new time course data indicating that constant glucocorticoid elevations generally corresponded with hippocampus-mediated learning deficits, whereas acute, cyclical elevations corresponded with improved initial acquisition. Sensitivity was greater for males than for females. Further, changes in hippocampal neurogenesis paralleled some but not all effects. The findings demonstrate that specific patterns of glucocorticoid elevation produced by different drug administration procedures can have markedly different, sex-specific consequences on basic cognitive performance and underlying hippocampal physiology. Implications of these findings for glucocorticoid medications prescribed in childhood are discussed.

show abstract

Section: 0 Corticosterone Effects On Eyeblink Trace Conditioningsupporting

confidence: 72%

Influence of postnatal glucocorticoids on hippocampal-dependent learning varies with elevation patterns and administration methods

Claflin

Schmidt

Vallandingham

et al. 2017

Neurobiology of Learning and Memory

View full text Add to dashboard Cite

show abstract

“…Corticosterone (C2505, Sigma‐Aldrich, St. Louis, MO) was dissolved in a mixture of 10% ethanol in sesame oil (S3547, Sigma‐Aldrich) and injected at a dose of 40 mg/kg and volume of 1 ml/kg. This dosing regimen has been repeatedly shown to increase serum CORT levels and produce metabolic and behavioral effects in rodents (Kott et al., ; Sterner & Kalynchuk, ). Rat body weight was measured daily.…”

Section: Methodsmentioning

confidence: 99%

“…In rodents, chronic injections of high‐dose CORT result in prolonged exposure to elevated CORT levels, abolishment of the circadian CORT rhythm, and depression‐like behaviors (Kott, Mooney‐Leber, Shoubah, & Brummelte, ; Li et al., ; Marks, Fournier, & Kalynchuk, ). We examined the effects of chronic CORT injections on the electrophysiological properties of DR neurons projecting to the medial prefrontal cortex (mPFC) or the lateral geniculate nucleus (LGN) of the thalamus.…”

Section: Introductionmentioning

confidence: 99%

Selective vulnerability of dorsal raphe‐medial prefrontal cortex projection neurons to corticosterone‐induced hypofunction

Prouty

Chandler

Gao

et al. 2019

Eur J of Neuroscience

View full text Add to dashboard Cite

Glucocorticoid hormones and serotonin (5‐HT) are strongly associated with the development and treatment of depression, respectively. Glucocorticoids regulate the function of serotonergic neurons in the dorsal raphe nucleus (DR), which are the major source of 5‐HT to the forebrain. DR 5‐HT neurons are electrophysiologically heterogeneous, though whether this phenotypic variation aligns with specific brain functions or neuropsychiatric disease states is largely unknown. The goal of this work was to determine if chronic exogenous glucocorticoid administration differentially affects the electrophysiological profile of DR neurons implicated in the regulation of emotion versus visual sensation by comparing properties of cells projecting to medial prefrontal cortex (mPFC) versus lateral geniculate nucleus (LGN). Following retrograde tracer injection into mPFC or LGN, male Sprague‐Dawley rats received daily injections of corticosterone (CORT) for 21 days, after which whole‐cell patch clamp recordings were made from retrogradely labeled DR neurons. CORT‐treatment significantly increased the action potential half‐width of LGN‐projecting DR neurons, but did not significantly affect the firing frequency or excitatory postsynaptic currents of these cells. CORT‐treatment significantly reduced the input resistance, evoked firing frequency, and spontaneous excitatory postsynaptic current frequency of mPFC‐projecting DR neurons, indicating a concurrent reduction of both intrinsic excitability and excitatory drive. Our results suggest that the serotonergic regulation of cognitive and emotional networks in the mPFC may be more sensitive to the effects of glucocorticoid excess than visual sensory circuits in the LGN and that reduced 5‐HT transmission in the mPFC may underlie the association between glucocorticoid excess and depression.

show abstract

“…The impact of chronic oral corticosterone treatments on hippocampal cellular proliferation and neurogenesis during adolescence is currently unknown, but may also show age-dependent effects like those observed in the context of metabolism. As alluded to above, it has been shown that exposing adult rats and mice to chronically elevated corticosterone levels reduce hippocampal proliferation and neurogenesis (Murray et al, 2008; David et al, 2009; Brummelte and Galea, 2010; Rainer et al, 2012; Kott et al, 2016). Thus, given the substantial developmental change in proliferation and neurogenesis and the ability of corticosterone to disrupt these processes, it is possible that the chronic oral corticosterone treatments known to affect metabolism differentially during adolescence and adulthood will also result in age-dependent perturbations of these neurobiological parameters.…”

Section: Introductionmentioning

confidence: 99%

“…In the second set of experiments, we exposed male and female mice to oral corticosterone treatments during either adolescence or adulthood. Given the greater change in hippocampal cellular proliferation and neurogenesis during adolescence (Heine et al, 2004; Kim et al, 2004; He and Crews, 2007; Hodes et al, 2009; Ho et al, 2012), the age-dependent sensitivity to oral corticosterone in the context of metabolism, and the effects of corticosterone on these parameters in adulthood (Murray et al, 2008; David et al, 2009; Brummelte and Galea, 2010; Rainer et al, 2012; Kott et al, 2016), we hypothesized that corticosterone treatment would lead to different effects in the adolescent- compared to adult-treated mice. Finally, though we did not compare males and females directly, the inclusion of both sexes in these studies allowed us to explore whether males and females are affected differently by these treatments, as previous studies report sex differences in the response of the hippocampus to stress-related hormones (Gobinath et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Adolescent Changes in Cellular Proliferation in the Dentate Gyrus of Male and Female C57BL/6N Mice Are Resilient to Chronic Oral Corticosterone Treatments

Shome

Sultana

Siddiqui

et al. 2018

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Adolescent development is marked by significant changes in neurobiological structure and function. One such change is the substantial adolescent-related decline in cellular proliferation and neurogenesis in the dentate gyrus of the hippocampal formation. Though the behavioral implications of these developmental shifts in cell proliferation are unclear, these changes might contribute to the altered cognitive and emotional functions associated with puberty and adolescence. The significant decrease in cellular proliferation throughout adolescence might make the hippocampus more vulnerable to perturbations during this developmental stage, particularly to factors known to disrupt neurogenesis, such as chronic exposure to stress-related hormones. To examine this possibility, we first measured cellular proliferation in the dentate gyrus of male and female C57BL/6N mice before and after adolescence and then assessed both cellular proliferation and the number of immature neurons in mice treated with oral corticosterone for 4 weeks during either adolescence or adulthood. We found significant age-related decreases in hippocampal cellular proliferation in both males and females. Though the greatest decrease in proliferation was during adolescence, we also observed that proliferation continued to decline through young adulthood. Despite the significant effect of chronic oral corticosterone on body weight gain in both the adolescent- and adult-treated males and females and the subtle, but significant suppressive effect of corticosterone on the number of immature neurons in the adolescent-treated males, cell proliferation in the hippocampus was unaffected by these treatments. These data show that the substantial adolescent-related change in cellular proliferation in the dentate gyrus is largely unaffected by chronic oral corticosterone exposure in males and females. Thus, despite being vulnerable to the metabolic effects of these chronic corticosterone treatments, these results indicate that the developmental changes in cellular proliferation in the dentate gyrus are relatively resilient to these treatments in mice.

show abstract

Effectiveness of different corticosterone administration methods to elevate corticosterone serum levels, induce depressive-like behavior, and affect neurogenesis levels in female rats

Cited by 54 publications

References 51 publications

Influence of postnatal glucocorticoids on hippocampal-dependent learning varies with elevation patterns and administration methods

Influence of postnatal glucocorticoids on hippocampal-dependent learning varies with elevation patterns and administration methods

Selective vulnerability of dorsal raphe‐medial prefrontal cortex projection neurons to corticosterone‐induced hypofunction

Adolescent Changes in Cellular Proliferation in the Dentate Gyrus of Male and Female C57BL/6N Mice Are Resilient to Chronic Oral Corticosterone Treatments

Contact Info

Product

Resources

About