Effectiveness of confidential unit exclusion in screening blood donors of the regional blood bank in Londrina, Paraná State

Vogler, Ingridt Hildegard; Saito, Mariza; Spinosa, Adriana Aparecida; Silva, Marilza Celina da; Munhoz, Egberto; Reiche, Edna Maria Vissoci

doi:10.5581/1516-8484.20110097

Cited by 10 publications

(18 citation statements)

References 22 publications

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“…In our study, about 2% of the first-time donors used the CUE option (CUE-positive), while only 0.8% of repeated and regular donors did. This rate of CUE positivity among the first-time donors in our study is lower than that in the study of Vogler et al [26], who reported about 5% CUE positivity among their first-time donors.…”

Section: Discussioncontrasting

confidence: 88%

First-Time Blood Donors are Double Edged Swords for Blood Transfusion Centers: a Retrospective Study in Southwest Iran

Niazkar¹,

Dorgalaleh²,

Rad³

2019

Tjh

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Objective: First-time blood donors are the most common group of blood donors. They usually have different motivations for blood donation, some of which provoke the donors to hide risk factors of transfusion-transmissible infections (TTIs). Therefore, detection of TTIs among first-time donors is crucial and can decrease the rate of TTIs among blood recipients. This study aimed to evaluate the prevalence of TTIs among first-time donors in the transfusion center of Kohgiluyeh and Boyer-Ahmad Province (KBTC), Iran. Materials and Methods:This retrospective study was conducted with volunteer blood donors in 2004-2014 in the KBTC. Various data, including sex, confidential unit exclusion (CUE), previous donation history, and the laboratory findings of confirmatory tests, were extracted from blood donor software. Data were analyzed by SPSS using the chi-square test.Results: Among 198,501 blood donors, 52,527 (26.46%) were firsttime donors, while 145,974 donors (73.54%) were repeat and regular donors. Most of the donors (94.5%) were male, while a minority (5.5%) were female. The CUE option was chosen by 2,237 (1.13%) donors. The incidence of hepatitis B surface antigen (HBsAg) and hepatitis C virus (HCV) was 247 (0.13%) and 134 (0.07%) among the entire study population, respectively. Three donors (0.002%) had confirmed human immunodeficiency virus (HIV), while none of the blood donors were positive for syphilis. Most of the donors with positive HBsAg (95.8%), HCV (86.6%), and HIV (100%) infection were first-time donors. Conclusion:Since TTIs are more common among first-time blood donors than regular and repeat donors, special considerations should be taken into account for this common group of blood donors.Amaç: Kan donörlerinin büyük çoğunluğunu ilk kez kan veren donörler oluşturmaktadır. Bu kişilerin genellikle kan vermek için farklı motivasyonları vardır ve bu da vericilerin transfüzyon ilişkili enfeksiyonları (TTI) saklaması açısından risk oluşturur. Bu nedenle ilk kez verici olanlarda TTI'ları tespit etmek çok önemlidir ve böylece kan alıcılarında TTI'lar azaltılabilir. Bu çalışmada amaç İran'da Kohgiluyeh ve Boyer-Ahmad Bölgesi (KBTC) transfüzyon merkezindeki ilk kez verici olan kan donörlerinde TTI prevelansının araştırılmasıdır. Gereç ve Yöntemler:Bu çalışma, KBTC'de 2004-2014 yılları arasında gönüllü kan vericilerinin dahil edildiği retrospektif bir çalışmadır. Cinsiyet, gizli ünite dışlaması (CUE), daha önceki kan bağışları, ve doğrulama testlerinin laboratuvar bulguları gibi veriler, kan vericileri yazılımından elde edilmiştir. Elde edilen veriler ki-kare testi kullanılarak SPSS ile değerlendirilmiştir. : 198,501 kan vericisinden 52,527'i (%26,46) ilk kez kan veren donörler, 145,974'i ise düzenli olarak kan verenler veya daha önce kan vermis olanlardı (%73,54). Vericilerin çoğu erkekti (%94,5), kadın verciler azınlıktaydı (5,5%). CUE seçeneği 2,237 (%1,13) verici tarafından kullanılmıştı. Bütün çalışma grubunda hepatit B yüzey antijeni (HBsAg) ve hepatit C virüsü (HCV) sıklığı sırasıyla 247 (%0,13) ve 134 (%0,0...

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Section: Discussioncontrasting

confidence: 88%

First-Time Blood Donors are Double Edged Swords for Blood Transfusion Centers: a Retrospective Study in Southwest Iran

Niazkar¹,

Dorgalaleh²,

Rad³

2019

Tjh

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“…The reduced functional capacity of patients with cGVHD has been confirmed by measurements made in the tests 2MWT (15,53,61,70,71,81,84,85), HGS (15,53,61,71,81,85,86), forced expiratory volume (FEV 1 ) (15,53,86,87), ROM (53,61,84,85) and P-ROM (84). Such functional decline is more marked in patients ≥60 years (70) or with overlap syndrome (as indicated by a longer 2MWT in both cases) (15).…”

Section: Clinical Manifestations Of Cgvhd: Implications For Patients’mentioning

confidence: 76%

Physical function and quality of life in patients with chronic GvHD: a summary of preclinical and clinical studies and a call for exercise intervention trials in patients

Fiuza‐Luces

Simpson

Ramı́rez

et al. 2015

Bone Marrow Transplant

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Allogeneic Hematopoietic Stem Cell Transplant, to reconstitute hematopoietic and immune status of patients undergoing myeloablative therapy for hematologic disorders, has been of great benefit in minimizing or eradicating disease and extending survival. Patients who undergo allogeneic hematopoietic stem cell transplant (allo-HSCT) are subject to many comorbidities among which the most significant, affecting quality of life (QoL) and survival, are acute (aGVHD) and chronic Graft Versus Host Disease (cGVHD), resulting from donor lymphocytes reacting to and damaging host tissues. Physical activity and exercise have clearly been shown, in both children and adults, to enhance fitness, improve symptomatology and QoL, reduce disease progression and extend survival for many diseases including malignancies. In some cases, vigorous exercise has been shown to be equal to or more effective than pharmacologic therapy. This review addresses how cGVHD affects patients’ physical function and physical domain of QoL, and the potential benefits of exercise interventions along with recommendations for relevant research and evaluation targeted at incorporating this strategy as soon as possible after allo-HSCT and ideally, as soon as possible upon diagnosis of the condition leading to allo-HSCT.

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“…However, studies performed in Uberaba, State of Minas Gerais and Londrina, State of Paraná, showed higher self-exclusion rates (2.7 and 3.2%, respectively) 57,58 . Although no clinical or epidemiological variables were related to CSE in this study, previous studies have shown that males and fi rst-time donors respond yes on the CSE form more frequently 28,[57][58][59][60] . However, the greater the number of repeated donations, the fewer times the CSE form was used to self-exclude the donor's blood 57,60 .…”

Section: Discussionmentioning

confidence: 67%

“…The main factors related to problems with the CSE form are the diffi culty of understanding the question 26,28,57,58 , the low socioeconomic status of the donors 58,59 , and the ineffective explanations by health professionals 58 . Another aspect to be considered is the varied format and content of the form, which are different for each blood bank 57,58 . It was shown that blood banks that use forms with plain text and color pictures have a lower frequency of affi rmative responses to the self-exclusion choice, leading to a reduction in the disposal of low-risk blood bags and to an increase in the sensitivity of the procedure.…”

Section: Discussionmentioning

confidence: 99%

“…The sensitivity and positive predictive values of CSE are quite low 22,58,[61][62][63] , leading to the disposal of many blood bags from potentially healthy donors. The main factors related to problems with the CSE form are the diffi culty of understanding the question 26,28,57,58 , the low socioeconomic status of the donors 58,59 , and the ineffective explanations by health professionals 58 . Another aspect to be considered is the varied format and content of the form, which are different for each blood bank 57,58 .…”

Section: Discussionmentioning

confidence: 99%

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Positive serology for viral hepatitis and donor self-exclusion in Southern Brazil

Maccarini

Nazário

Ferreira

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction: Despite the great advances in serological testing for transfusion-transmitted infections, the selection of blood donors by blood bank operators remains the only way to avoid transmission within the testing window period. Part of this selection is the self-exclusion form, on which the donors can exclude their blood from donation without any explanation. This study assessed the clinical and epidemiological characteristics related to positivity for viral hepatitis and to the use of the confi dential self-exclusion (CSE) form. Methods: This transversal study analyzed the data collected from blood donors' fi les in a hospital in Southern Brazil. Univariate and multivariate analyses identifi ed the clinical and epidemiological variables related to positive serologies of viral hepatitis and to whether the donor was self-excluded. Results: Of the 3,180 donors included in this study, 0.1% tested positive for HBsAg, 2.1% for anti-HBc, and 0.9% for anti-HCV. When the 93 donors with positive serologies for viral hepatitis were compared with those who were negative, a greater proportion of the positive serology group was found to have had a history of blood transfusions (OR=4.908; 95%CI=1.628 -14.799; p<0.01), had repeatedly donated (OR=2.147; 95%CI=1.236 -3.729; p<0.01), and used the CSE form for self-exclusion (OR=7.139; 95%CI=2.045 -24.923; p<0.01). No variables were independently associated with self-exclusion. Conclusions: A history of blood transfusion, repeated donations, and self-exclusion are factors that should be considered during viral hepatitis screenings in blood banks.

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Effectiveness of confidential unit exclusion in screening blood donors of the regional blood bank in Londrina, Paraná State

Cited by 10 publications

References 22 publications

First-Time Blood Donors are Double Edged Swords for Blood Transfusion Centers: a Retrospective Study in Southwest Iran

First-Time Blood Donors are Double Edged Swords for Blood Transfusion Centers: a Retrospective Study in Southwest Iran

Physical function and quality of life in patients with chronic GvHD: a summary of preclinical and clinical studies and a call for exercise intervention trials in patients

Positive serology for viral hepatitis and donor self-exclusion in Southern Brazil

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