Effectiveness of BNT162b2 COVID-19 vaccine among healthcare workers of a large hospital, Milan, Italy

Consonni, Dario; Lombardi, Andrea; Mangioni, Davide; Bono, Patrizia; Oggioni, Massimo; Renteria, Sara Colonia Uceda; Bordini, Lorenzo; Nava, Carlo; Letzgus, Matteo; Silverj, Flaminia Gentiloni; Castaldi, Silvana; Rognoni, M; Doro, Luca; Carugno, Michele; Pesatori, Angela Cecilia; Riboldi, Luciano; Ceriotti, Ferruccio; Bandera, Alessandra; Gori, Andrea

doi:10.1016/j.shaw.2021.12.1439

Cited by 4 publications

(5 citation statements)

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“…As far as the occupational risk factors of the infection were concerned, not surprisingly, healthcare workers were the most exposed to SARS-CoV-2, followed by dealers, vehicle repairers and sportsmen. Similarly high seroprevalence of anti-SARS-CoV-2 antibodies in healthcare workers had already been identified, particularly in the areas of Northern Italy heavily affected by the pandemic [ 15 , 25 , 26 ], with a corresponding value in the national survey of 5.3% [ 21 ]. This clearly highlights the high infection risk experienced by this crucial sector and the importance of increasing their protection towards SARS-CoV-2 contact.…”

Section: Discussionmentioning

confidence: 79%

Seroprevalence of anti-SARS-CoV-2 antibodies in the Northern Italy population before the COVID-19 second wave

Berselli¹,

Filippini²,

Paduano³

et al. 2022

Int J Occup Med Environ Health

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Objectives: The COVID-19 pandemic is due to SARS-CoV-2 coronavirus infections. It swept across the world in the spring of 2020, and so far it has caused a huge number of hospitalizations and deaths. In the present study, the authors investigated serum anti-SARS-CoV-2 antibody prevalence in the period of June 1-September 25, 2020, in 7561 subjects in Modena, Northern Italy. Material and Methods: The study population included 5454 workers referred to testing by their companies, and 2107 residents in the Modena area who accessed testing through self-referral. Results: The authors found the overall seroprevalence to be 4.7% (95% confidence interval [CI] 4.2-5.2%), which was higher in women (5.4%, 95% CI: 4.5-6.2%) than in men (4.3%, 95% CI: 3.7-4.9%), and in the oldest age groups (7.3%, 95% CI: 5.2-9.3% for persons aged 60-69 years, and 11.8%, 95% CI: 8.6-15.1%, for persons aged ≥70 years). Among the occupational categories, the highest seroprevalence was found in healthcare workers (8.8%, 95% CI: 7.0-10.5%), dealers and vehicle repairers (5.2%, 95% CI: 2.9-7.6%), and workers in the sports sector (4.0%, 95% CI: 1.8-6.1%), while there was little or no such evidence for those employed in sectors such as transport and storage, accommodation and restaurant services, and the school system. Conclusions: These results have allowed, for the first time, to assess population seroprevalence in this area of Italy severely hit by the epidemic, while at the same time identifying the subgroups at a higher risk of exposure to SARS-CoV-2. Int J Occup Med Environ Health. 2022;35(1)

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Section: Discussionmentioning

confidence: 79%

Seroprevalence of anti-SARS-CoV-2 antibodies in the Northern Italy population before the COVID-19 second wave

Berselli¹,

Filippini²,

Paduano³

et al. 2022

Int J Occup Med Environ Health

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“…This effect may apply to cases reported in 2022, but this lag cannot explain the downward trend in case severity in 2021. In light of the extensive literature on the protective effects of COVID-19 vaccination and infection or both [26][27][28][29], we believe it is likely that the observed association is likely to indicate a causal relationship.…”

Section: Discussionmentioning

confidence: 94%

COVID-19 as an Occupational Disease—Temporal Trends in the Number and Severity of Claims in Germany

Nienhaus

Stranzinger²,

Kozak³

2023

IJERPH

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COVID-19 is considered an occupational disease (OD), when infection occurs at the workplace for health workers (HW). Because of the increased infection risk of these workers, they were deemed to be a priority group when the vaccination campaign started in Germany in December 2020. By December 2021, more than 90% of HW had been vaccinated twice. We studied the number and the time trend concerning the severity of OD claims related to COVID-19. Workers’ compensation claims for OD are recorded in a standardized database of the Statutory Accident Insurance and Prevention in the Health and Welfare Services (BGW). We analyzed all notifiable COVID-19 related claims filed between 1 March 2020 and 30 September 2022. The proportion of severe cases was estimated by inpatient stays, injury benefit payments, rehabilitation measures, and deaths. The data analysis was descriptive. Due to COVID-19, 317,403 notifiable cases were reported to the BGW. Of these, 200,505 (63.2%) had thus far been recognized as OD. The number of notifiable cases was highest in 2022 and lowest in 2020. In total, 3289 insured individuals were admitted to rehabilitation management. This represented 1.6% of all recognized ODs due to COVID-19 at the BGW. The proportion of cases admitted to rehabilitation management decreased from 4.5% of all recognized ODs in 2020 to 3.2% in 2021 and to 0.1% of all recognized cases in 2022. For inpatient stays, injury benefit payment, and death, a similar trend was observed. Therefore, it might be concluded that the successful vaccination campaign mitigated the negative health effects of COVID-19 on HW. Even with vaccination, severe cases can occur. Therefore, infection prevention at the workplace remains paramount.

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“…Prevalence of 55 long-term effects [ 23 ] was evaluated, as well as that of consequent effects in terms of perceived work ability and fitness to work [ 24 ]. Some studies have investigated the influence of previous infection and vaccination in COVID-19 prevention considering the rate of reinfection or assessing the level of neutralizing antibodies after vaccination to evaluate the protective effect of vaccination [ 25 , 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of the Third Dose of COVID-19 Vaccine: When Should It Be Performed?

Biganzoli,

Mendola,

Perrone

et al. 2024

Vaccines

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Background: COVID-19 vaccination is the most significant step toward the long-term mitigation of SARS-CoV-2-related complication, avoiding disease and death and decreasing virus spread. This study aimed to evaluate, in a real-world setting, booster dose effectiveness to reduce COVID-19 risk considering the amount of time after the end of the two-dose vaccination cycle. A sub-analysis was conducted to adjust the booster dose effect for occupational and demographic factors. Methods: About 16,000 COVID-19-vaccinated HCWs of three University Hospital Networks in Milan (HN1/HN2/HN3) were included in the study. Data were collected by Occupational Health Physicians of the HNs within specific computerized databases. Results: In univariable analysis, booster dose administration displayed a slightly higher risk of infection with respect to not receiving it, OR = 1.18, with 95% confidence interval (C.I) [0.99, 1.41]. When the model was adjusted with the modulating effect of time from the completion of the vaccination cycle on booster dose administration, the latter resulted in strong protective effect against infection, OR = 0.43, 95% CI [0.26, 0.74]. However, considering the modifying influence of time from the vaccination cycle’s completion, the administration of booster doses appeared to have a protective effect against infection. In HN1, students and resident physicians displayed lower odds of infection with respect to physicians. Lastly, a non-linear effect of age was reported. Conclusions: Our findings suggest that the correct timing in vaccine scheduling and administration is critical to vaccine effectiveness. These findings, applicable to all vaccinations, should help in setting up more effective vaccination strategies.

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Effectiveness of BNT162b2 COVID-19 vaccine among healthcare workers of a large hospital, Milan, Italy

Cited by 4 publications

References 0 publications

Seroprevalence of anti-SARS-CoV-2 antibodies in the Northern Italy population before the COVID-19 second wave

Seroprevalence of anti-SARS-CoV-2 antibodies in the Northern Italy population before the COVID-19 second wave

COVID-19 as an Occupational Disease—Temporal Trends in the Number and Severity of Claims in Germany

The Effectiveness of the Third Dose of COVID-19 Vaccine: When Should It Be Performed?

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