Effectiveness of a nationwide nosocomial infection surveillance system for reducing nosocomial infections

Gastmeier, Petra; Geffers, Christine; Brandt, Christian; Zuschneid, Irina; Sohr, Dorit; Schwab, Frank J.; Behnke, Michael; Daschner, Franz; Rüden, H.

doi:10.1016/j.jhin.2006.04.017

Cited by 238 publications

(128 citation statements)

References 23 publications

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“…Some studies have reported the importance of controlling nosocomial infection to reduce the number of these infections, which provides economic benefits (Gastmeier et al, 2006;Rosenthal, Maki, Graves, 2008;Landelle, Marimuthu, Harbarth, 2014).…”

Section: Introductionmentioning

confidence: 99%

β-lactamase-producing Gram-negative bacteria in an intensive care unit in southern Brazil

Leite

Oizumi

Caleffi-Ferracioli

et al. 2017

Braz. J. Pharm. Sci.

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The present study evaluated the antimicrobial susceptibility profile, b-lactamase production, and genetic diversity of Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter spp. using phenotypic identification, antimicrobial susceptibility testing, and b-lactamase phenotypic detection. Isolates were obtained from patients in an intensive care unit in a hospital in southern Brazil. Bacterial genomic DNA was extracted, followed by the genotypic detection of carbapenemases and enterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR). Fifty-six isolates (26 Klebsiella pneumoniae, five Escherichia coli, three Enterobacter aerogenes, nine P. aeruginosa, and 13 Acinetobacter spp.) were evaluated. The phenotypic extended spectrum b-lactamase (ESBL) test was positive in 53.8% of the K. pneumoniae isolates, 100.0% of the E. coli isolates, and 100.0% of the E. aerogenes isolates. Phenotypic and genotypic testing of K. pneumoniae carbapenemase (KPC) was positive in 50.0% of the K. pneumoniae isolates. Phenotypic and genotypic testing showed that none of the P. aeruginosa or Acinetobacter spp. isolates were positive for metallo-b-lactamase (MBL). The bla OXA gene was detected only in Acinetobacter spp. The lowest genetic diversity, determined by ERIC-PCR, was observed among the KPC-producing K. pneumoniae isolates and OXA-producing Acinetobacter spp. isolates, indicating the inadequate dissemination control of multidrug-resistant bacteria in this hospital environment.

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Section: Introductionmentioning

confidence: 99%

β-lactamase-producing Gram-negative bacteria in an intensive care unit in southern Brazil

Leite

Oizumi

Caleffi-Ferracioli

et al. 2017

Braz. J. Pharm. Sci.

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“…[2]. [11] On this background this study was undertaken to determine the epidemiology and rate of CAUTIs, risk factors, microbiological profileand their antimicrobial susceptibilities. In a catheterized patient, urine sample (3 mL) were collected as per the guidelines for culture and sensitivity with aseptic precautions using a sterile needle and syringe from the distal edge of catheter tube into a sterile universal container [12] and was transported immediately to the laboratory.…”

Section: Introductionmentioning

confidence: 99%

The Epidemiology and Microbiological pattern of Catheter Associated Urinary Tract Infection in a Tertiary Care Hospital- A Surveillance Study

Ushakrishnan¹

2017

jmscr

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“…Hospitalized patients in these areas often suffer from a debilitating physical condition, deficiencies of the immune system, and severe infectious complications including nosocomial infections requiring intense antibiotic therapy for long periods. These types of infections are not only difficult to treat, but also have a significant adverse economic impact on the healthcare system in terms of costs, increased length of hospital stay, morbidity, and mortality [3][4][5]. Antibiotic resistance among GNB are increasing continuously and this issue must be dealt with as a major worldwide issue [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Gram-negative bacilli causing infections in an intensive care unit of a tertiary care hospital in Istanbul, Turkey

Şenbayrak

İnan

Cevan

et al. 2014

J Infect Dev Ctries

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Introduction: This study aimed to demonstrate the changing epidemiology of infecting microorganisms and their long-term resistance profiles and to describe the microbiological point of view in anti-infective management of intensive care unit (ICU) patients. Methodology: A total of 5,690 isolates of Gram-negative bacilli were included in this study. Antibiotic susceptibility was tested using the disk diffusion method and Vitek 2 system. Chi-square tests were used for hypothesis testing. Results: The most frequently isolated organisms were A. baumannii (37.3%), P. aeruginosa (30.3%), Enterobacter spp. (10.4%), E. coli (10.4%), and Klebsiella spp. (8.9%). A. baumannii was the most frequently isolated organism from the respiratory tract (43.4%); the susceptibility rates for imipenem and meropenem decreased to 7% and 6% (p < 0.0001), respectively. The percentage of multidrug-resistant (MDR) A. baumannii isolates continuously increased from 18.7% in 2004 to 69% in 2011 (p < 0.0001), whereas MDR P. aeruginosa isolates increased from 1.5% to 22% (p < 0.0001). Carbapenem-resistant Klebsiella isolates emerged in 2010 and increased to 20% in the next year. The rates of ESBL-producing Enterobacteriaceae in the ICU was very high in 2011 -50% for E. coli and 80% for Klebsiella strains. Conclusion: The most common isolated Gram-negative bacillus in our study was A. baumannii and that the prevalence of MDR isolates has increased markedly over. Accordingly, the comparison of antibiotic resistance of other pathogens in 2004 and 2011 displayed an increasing trend. These data imply the urgent need for new and effective strategies in our hospital and in the region.

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Effectiveness of a nationwide nosocomial infection surveillance system for reducing nosocomial infections

Cited by 238 publications

References 23 publications

β-lactamase-producing Gram-negative bacteria in an intensive care unit in southern Brazil

β-lactamase-producing Gram-negative bacteria in an intensive care unit in southern Brazil

The Epidemiology and Microbiological pattern of Catheter Associated Urinary Tract Infection in a Tertiary Care Hospital- A Surveillance Study

Gram-negative bacilli causing infections in an intensive care unit of a tertiary care hospital in Istanbul, Turkey

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