Effectiveness of a Chlorhexidine Digluconate 0.12% and Cetylpyridinium Chloride 0.05% Solution in eliminating Candida albicans Colonizing Dentures: A Randomized Clinical in vivo Study

Cassia, Antoine

doi:10.5005/jp-journals-10024-1702

Cited by 25 publications

(9 citation statements)

References 19 publications

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“…These opportunistic microorganisms are found in biofilm extremely adherent to the base material of the dentures especially within the micro-fissures and cracks when they exist (14). Under the influence of various predisposing factors, Candida albicans undergo structural changes to become pathogenic; thus contributing to the disease onset.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Denture-related Factors Predisposing to Denture Stomatitis in a Lebanese Population

Aoun¹,

Cassia²

2016

Mater Sociomed

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Background:Denture stomatitis is a common fungal oral infection of multifactorial etiology. Denture-related factors such as denture’s age, hygiene, night wearing and colonization by Candida albicans are known to predispose to denture stomatitis. The aim of this study was to evaluate these factors and their relationship with the occurrence of denture stomatitis in a Lebanese population.Material and methods:Sixty patients (40 women, 20 men; age range 40-80 years) showing clinical evidence of denture-related stomatitis were selected for this study. Swab samples from the palate and the palatal surfaces of the upper dentures of these patients were collected and examined mycologically. Denture’s age, hygiene, night wearing and colonization by Candida albicans were evaluated and analyzed statistically.Results:The statistical analysis showed a significant role for denture’s hygiene, night wearing, and colonization by Candida albicans in the installation of the denture stomatitis. Patient’s gender and age, as well as the denture’s age, were not significant predictors of the disease.Conclusion:In a sample of Lebanese population, poor denture hygiene, continuous denture use, and Candida denture colonization are important etiological factors that contribute to denture stomatitis.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Denture-related Factors Predisposing to Denture Stomatitis in a Lebanese Population

Aoun¹,

Cassia²

2016

Mater Sociomed

Self Cite

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“…Many species of microorganisms found in biofilm adherent to the base material of dentures, usually presenting micro-fissures and cracks or having the roughness of the surface increased, can lead to many mucosal/oral diseases installation when conditions are favorable ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Hygiene Habits in Acrylic Denture Wearers: a Cross-sectional Study

Aoun¹,

Gerges²

2017

Mater Sociomed

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Objectives:To assess the denture hygiene habits in a population of Lebanese denture wearers.Materials and Methods:One hundred and thirty-two (132) patients [71 women (53.8%) and 61 men (46.2%)] wearing their acrylic dentures for more than two years were included in this study. The hygiene methods related to their dentures were evaluated and the data obtained were analyzed statistically using the IBM® SPSS® statistics 20.0 (USA) statistical package.Results:Regardless of the cleaning technique, the big majority of our participants [123 out of 132 (93.1%)] cleaned their dentures daily. The two mostly used denture cleaning techniques were rinsing with tap water (34.1%) and brushing with toothpaste (31.8%). Nearly half of our patients (45.5%) soaked their dentures during the night; most of them with cleansing tablets dissolved in water (28.8%).Conclusions:Within the limitations of our study, it was concluded that in a sample of Lebanese population surveyed about denture hygiene habits, the daily frequency of denture cleaning is satisfactory, but the techniques and products used were self-estimated and, consequently, not sufficient.

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“…In today's clinical dental practice, CPC is mainly used as an antimicrobial ingredient in over-the-counter products such as mouthwashes and dentifrices, which are marketed for reducing plaque accumulation and gingival inflammation (16,17,24). Furthermore, the combination of CPC with other antiseptics like CHX or the mixture of multiple QACs with various side chain lengths has been proposed in recent years for a potential increase of antimicrobial activity when applied in mouthwashes (18,25).…”

mentioning

confidence: 99%

Cetylpyridinium Chloride: Mechanism of Action, Antimicrobial Efficacy in Biofilms, and Potential Risks of Resistance

Mao

Auer

Buchalla

et al. 2020

Antimicrob Agents Chemother

127

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Antimicrobial resistance is a serious issue for public health care all over the world. While resistance toward antibiotics has attracted strong interest among researchers and the general public over the last 2 decades, the directly related problem of resistance toward antiseptics and biocides has been somewhat left untended. In the field of dentistry, antiseptics are routinely used in professional care, but they are also included in lots of oral care products such as mouthwashes or dentifrices, which are easily available for consumers over-the-counter. Despite this fact, there is little awareness among the dental community about potential risks of the widespread, unreflected, and potentially even needless use of antiseptics in oral care. Cetylpyridinium chloride (CPC), a quaternary ammonium compound, which was first described in 1939, is one of the most commonly used antiseptics in oral care products and included in a wide range of over-the-counter products such as mouthwashes and dentifrices. The aim of the present review is to summarize the current literature on CPC, particularly focusing on its mechanism of action, its antimicrobial efficacy toward biofilms, and on potential risks of resistance toward this antiseptic as well as underlying mechanisms. Furthermore, this work aims to raise awareness among the dental community about the risk of resistance toward antiseptics in general.

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Effectiveness of a Chlorhexidine Digluconate 0.12% and Cetylpyridinium Chloride 0.05% Solution in eliminating Candida albicans Colonizing Dentures: A Randomized Clinical in vivo Study

Abstract: A solution of 0.12% CHX and 0.05% CPC tested as a product of disinfection of the acrylic dentures showed significant results after immersion of 8 night hours for 4 days.

Cited by 25 publications

References 19 publications

Evaluation of Denture-related Factors Predisposing to Denture Stomatitis in a Lebanese Population

Evaluation of Denture-related Factors Predisposing to Denture Stomatitis in a Lebanese Population

Assessment of Hygiene Habits in Acrylic Denture Wearers: a Cross-sectional Study

Cetylpyridinium Chloride: Mechanism of Action, Antimicrobial Efficacy in Biofilms, and Potential Risks of Resistance

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