Effectiveness and safety of endothelial keratoplasty for pseudophakic and aphakic bullous keratopathy: a systematic review of randomized controlled trials and cohort studies

Abstract

Objective: For nearly a century, penetrating keratoplasty has been the surgical technique of choice in the management

New ex vivo model of corneal endothelial phacoemulsification injury and rescue therapy with mesenchymal stromal cell secretome

“…17 At present, the only available choice for treating corneal endothelial dysfunction is corneal endothelial transplantation. 7,8,28 A possible alternative could be to use strategies that save partially damaged endothelial cells from apoptosis and help promote their repair and regeneration.…”

“…[4][5][6] Thus, despite advances, pseudophakic corneal edema remains a leading indication for endothelial keratoplasty. 7,8 In this study, we standardized an ex vivo model of corneal endothelial cell injury using phacoemulsification in porcine eyes and further evaluated the effect of corneal mesenchymal stromal cell secretome as a new therapy to reduce corneal endothelial cell loss.…”