volume 82, issue 10, P2631-2642 2014
DOI: 10.1002/prot.24627
View full text
Sign up to set email alerts

Abstract: Local structural entropy (LSE) is a descriptor for the extent of conformational heterogeneity in short protein sequences that is computed from structural information derived from the Protein Data Bank. Reducing the LSE of a protein sequence by introducing amino acid mutations can result in fewer conformational states and thus a more stable structure, indicating that LSE optimization can be used as a protein stabilization method. Here, we describe a series of LSE optimization experiments designed to stabilize m…

Expand abstract