Effective Treatment of Oral Erosive Lichen Planus With Thalidomide

Camisa, Charles; Popovsky, Jennifer Levin

doi:10.1001/archderm.136.12.1442

Cited by 56 publications

(27 citation statements)

References 4 publications

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“…Topical and systemic medications include immunosuppressants, such as cyclosporine and tacrolimus, and topical or systemic retinoids. 10 The treatment of refractory disease has also been approached with other agents, including thalidomide 11 and even nonpharmacologic agents such as psoralen-UV-A.…”

Section: O R a L L I C H E N P L A N U Smentioning

confidence: 99%

Oral Lichen Planus

Torti¹,

Jorizzo²,

McCarty³

2007

Arch Dermatol

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Section: O R a L L I C H E N P L A N U Smentioning

confidence: 99%

Oral Lichen Planus

Torti¹,

Jorizzo²,

McCarty³

2007

Arch Dermatol

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“…Long-term systemic steroids are usually effective, even if associated with a well-known spectrum of side effects and relapses following steroid withdrawal (11). Data about the efficacy of other therapeutic agents proposed in the treatment of LP, such as azathioprine or thalidomide, are limited and controversial (12,13). Recently, methotrexate has been proposed in the treatment of patients with erosive, treatment-refractory disease, with encouraging results (10).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of extracorporeal photochemotherapy in the treatment of a case of refractory erosive lichen planus

Zingoni¹,

Deboli²,

Savoia³

et al. 2009

J. of Dermatological Treatment

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Erosive lichen planus is characterized by painful, multi-focal erythematous-ulcerative areas affecting mucosal oral and genital areas. Topical therapies are usually ineffective, whereas systemic steroids and immunosuppressive agents are frequently associated with a wide spectrum of side effects. Herein, we presented our positive experience in the treatment of a case of multi-resistant erosive lichen planus with extracorporeal photochemotherapy.

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“…Thalidomide has potent anti-inflammatory activities, presumably mainly through the inhibition of the pathway of TNF-α. This knowledge further implicates that TNF-α may play an important role in the pathogenesis of LP [15, 16]. …”

Section: Discussionmentioning

confidence: 99%

Increased Serum Levels of Tumor Necrosis Factor Alpha in Lichen planus

et al. 2003

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Background: Lichen planus (LP) is a common, pruritic, inflammatory mucocutaneous disease. There are several opinions and approaches to the etiopathogenesis of LP. Immunologic mechanisms almost certainly mediate its development. T-cell-mediated immunity plays the major role in triggering the clinical expression of the disease. The cytokines that are produced by lymphocytes also play an important role in the development of LP. Objective: The goal of our study was to investigate the possible role of tumor necrosis factor α (TNF-α) in the pathogenesis of LP. Methods: Serum TNF-α levels were determined with the enzyme-linked immunosorbent sandwich assay method in the sera of 40 patients suffering from LP and in those of 40 healthy controls. Results: The serum levels of TNF-α were found to be significantly higher in the patient group compared to the healthy controls (patients: 35.64 ± 9.59 pg/ml, controls: 15.6 ± 3.97 pg/ml, p < 0.001). Conclusion: Our results revealed that TNF-α might play a major role in the pathogenesis of LP.

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Effective Treatment of Oral Erosive Lichen Planus With Thalidomide

Cited by 56 publications

References 4 publications

Oral Lichen Planus

Oral Lichen Planus

Effectiveness of extracorporeal photochemotherapy in the treatment of a case of refractory erosive lichen planus

Increased Serum Levels of Tumor Necrosis Factor Alpha in Lichen planus

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