Effective Neural Photostimulation Using Indium-Based Type-II Quantum Dots

Jalali, Houman Bahmani; Aria, Mohammad Mohammadi; Dikbas, Ugur Meric; Sadeghi, Sadra; Kumar, Baskaran Ganesh; Şahin, Mehmet; Kavaklı, İbrahim Halil; Ow‐Yang, Cleva W.; Nizamoğlu, Sedat

doi:10.1021/acsnano.8b02976

Cited by 52 publications

(52 citation statements)

References 83 publications

(151 reference statements)

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“…Cytotoxicity assay is performed as described by Bahmani Jalali et al [53]. Briefly, photoelectrodes are cut into 0.40 × 0.40 cm 2 pieces then sterilized by 70% ethanol treatment and 30-min ultraviolet (UV) light exposure.…”

Section: Mtt Assaymentioning

confidence: 99%

Band Alignment Engineers Faradaic and Capacitive Photostimulation of Neurons Without Surface Modification

et al. 2019

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Photovoltaic substrates have attracted significant attention for neural photostimulation. The control of the Faradaic and capacitive (non-Faradaic) charge transfer mechanisms by these substrates are critical for safe and effective neural photostimulation. We demonstrate that the intermediate layer can directly control the strength of the capacitive and Faradaic processes under physiological conditions. To resolve the Faradaic and capacitive stimulations, we enhance photogenerated charge density levels by incorporating PbS quantum dots into a poly(3-hexylthiophene-2,5-diyl):([6,6]-Phenyl-C61-butyric acid methyl ester (P3HT:PCBM) blend. This enhancement stems from the simultaneous increase of absorption, well matched band alignment of PbS quantum dots with P3HT:PCBM, and smaller intermixed phase-separated domains with better homogeneity and roughness of the blend. These improvements lead to the photostimulation of neurons at a low light intensity level of 1 mW cm −2 , which is within the retinal irradiance level. These findings open up an alternative approach toward superior neural prosthesis.

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Section: Mtt Assaymentioning

confidence: 99%

Band Alignment Engineers Faradaic and Capacitive Photostimulation of Neurons Without Surface Modification

et al. 2019

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“…2a). We used two band-pass filters at the photoluminescence peak wavelengths, excited the QDs in toluene at 375 nm and PL decays were fitted by two exponential decays 38,39 . While the inter-band transition revealed considerably shorter fluorescent decay time (τ = 15 ns), the surface state emission showed longer lifetime (τ = 129 ns) due to trapped charge carriers (Fig.…”

Section: Resultsmentioning

confidence: 99%

Efficient White LEDs Using Liquid-state Magic-sized CdSe Quantum Dots

Sadeghi

Abkenar

Ow‐Yang

et al. 2019

Sci Rep

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Magic clusters have attracted significant interest to explore the dynamics of quantum dot (QD) nucleation and growth. At the same time, CdSe magic-sized QDs reveal broadband emission in the visible wavelength region, which advantageously offer simple integration of a single-type of nanomaterial and high color rendering ability for white light-emitting diodes (LEDs). Here, we optimized the quantum yield of magic-sized CdSe QDs up to 22% via controlling the synthesis parameters without any shelling or post-treatment process and integrated them in liquid-state on blue LED to prevent the efficiency drop due to host-material effect. The fabricated white LEDs showed color-rendering index and luminous efficiency up to 89 and 11.7 lm/W, respectively.

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“…The cytotoxic effect of biointerfaces on SHSY-5Y cells was assessed by measuring the mitochondrial activity with the MTT assay. The MTT assay was performed as described by Bahmani Jalali et al 7 Briefly, biointerfaces and the ITO control were sterilized with 70% ethanol and followed by UV-C treatment for 5 min. Sterilized samples were placed in a six-well cell culture plate.…”

Section: Methodsmentioning

confidence: 99%

Plasmon-Coupled Photocapacitor Neuromodulators

Melikov

Srivastava

Karatum

et al. 2020

ACS Appl. Mater. Interfaces

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Efficient transduction of optical energy to bioelectrical stimuli is an important goal for effective communication with biological systems. For that, plasmonics has a significant potential via boosting the light–matter interactions. However, plasmonics has been primarily used for heat-induced cell stimulation due to membrane capacitance change (i.e., optocapacitance). Instead, here, we demonstrate that plasmonic coupling to photocapacitor biointerfaces improves safe and efficacious neuromodulating displacement charges for an average of 185% in the entire visible spectrum while maintaining the faradic currents below 1%. Hot-electron injection dominantly leads the enhancement of displacement current in the blue spectral window, and the nanoantenna effect is mainly responsible for the improvement in the red spectral region. The plasmonic photocapacitor facilitates wireless modulation of single cells at three orders of magnitude below the maximum retinal intensity levels, corresponding to one of the most sensitive optoelectronic neural interfaces. This study introduces a new way of using plasmonics for safe and effective photostimulation of neurons and paves the way toward ultrasensitive plasmon-assisted neurostimulation devices.

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Effective Neural Photostimulation Using Indium-Based Type-II Quantum Dots

Cited by 52 publications

References 83 publications

Band Alignment Engineers Faradaic and Capacitive Photostimulation of Neurons Without Surface Modification

Band Alignment Engineers Faradaic and Capacitive Photostimulation of Neurons Without Surface Modification

Efficient White LEDs Using Liquid-state Magic-sized CdSe Quantum Dots

Plasmon-Coupled Photocapacitor Neuromodulators

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