Effect of zinc versus vitamin A supplementation on pediatric patients with community-acquired pneumonia

Saied, Aya; Borolossy, Radwa Maher El; Ramzy, Mourad Alfy; Sabri, Nagwa A.

doi:10.3389/fphar.2022.933998

Cited by 7 publications

(25 citation statements)

References 53 publications

(76 reference statements)

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“…[33][34][35] The relationship between vitamin D and zinc (Zn) levels and pneumonia was investigated, and it was revealed that vitamin and mineral deficiencies predispose to pneumonia. 36,37 In our study, we demonstrated a negative relationship between the income level of the family and the intake of nutritional support. Again, we detected a negative relationship between education level and vitamin D levels and a negative relationship between Zn levels in patients with cardiovascular system disease.…”

Section: Discussionsupporting

confidence: 48%

The Relationship Between Dyspnea Severity with Radiological and Laboratory Findings in Pneumonia in Children in Pediatric Palliative Care

Harputluoğlu

Coşkun

Çubukçu

et al. 2023

JPA

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In care patients; pneumonia is common due to being bedridden, atrophy of respiratory muscles and use of medical devices.Dyspnea is the second most common symptom after pain in pediatric palliative care. In this study, it was aimed to examine therelationship between the severity of dyspnea and pneumonia. The study is a study that included patients admitted to pediatricpalliative care, diagnosed with pneumonia, and applied Modified Borg Scale (MBS) between December 15, 2019 and December15, 2020. The MBS has a scoring system ranging from 0 to 10 and assesses the severity of dyspnea. A total of 72 (34.4%) patientsdiagnosed with pneumonia and underwent MBS were included in the study. 51.4% (n=37) of the study group were male, and themedian age was 6.00 years (ranges of quarters=9). It was observed that the severity of dyspnea did not affect determining thepneumonia type and possible pathogen (p=0.613, p=0.948, respectively) In line with the results of the study, it can be concludedthat there is no relationship between the severity of dyspnea and pneumonia in patients in need of care.

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Section: Discussionsupporting

confidence: 48%

The Relationship Between Dyspnea Severity with Radiological and Laboratory Findings in Pneumonia in Children in Pediatric Palliative Care

Harputluoğlu

Coşkun

Çubukçu

et al. 2023

JPA

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“…Two RCTs on vitamin A supplementation reported divergent results. Enteral vitamin A supplementation reduced the length of hospital stay and pneumonic effusion in critically ill children with community-acquired pneumonia, but intramuscular vitamin A supplementation was not beneficial to critically ill septic adults [32,36].…”

Section: Vitamin Amentioning

confidence: 93%

“…There were no benefits in neurocritical patients, whereas a mortality benefit was shown in septic patients with AKI [30,31]. In addition, zinc supplementation in critically ill children with community-acquired pneumonia significantly shortened hospital length of stay and duration of pneumonic effusion [32].…”

Section: Zincmentioning

confidence: 97%

An update on essential micronutrients in critical illness

Berger

2023

Current Opinion in Critical Care

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Purpose of review Numerous micronutrients are involved in antioxidant and immune defence, while their blood concentrations are frequently low in critically ill patients: this has fuelled many supplementation trials. Numerous observational, randomized studies have been published, which are presented herein. Recent findings Micronutrient concentrations must be analysed considering the context of the inflammatory response in critical illness. Low levels do not always indicate a deficiency without objective micronutrients losses with biological fluids. Nevertheless, higher needs and deficiencies are frequent for some micronutrients, such as thiamine, vitamins C and D, selenium, zinc and iron, and have been acknowledged with identifying patients at risk, such as those requiring continuous renal replacement therapy (CRRT). The most important trials and progress in understanding have occurred with vitamin D (25(OH)D), iron and carnitine. Vitamin D blood levels less than 12 ng/ml are associated with poor clinical outcomes: supplementation in deficient ICU patients generates favourable metabolic changes and decreases mortality. Single high-dose 25(OH)D should not be delivered anymore, as boluses induce a negative feedback mechanism causing inhibition of this vitamin. Iron-deficient anaemia is frequent and can be treated safely with high-dose intravenous iron under the guidance of hepcidin to confirm deficiency diagnosis. Summary The needs in critical illness are higher than those of healthy individuals and must be covered to support immunity. Monitoring selected micronutrients is justified in patients requiring more prolonged ICU therapy. Actual results point towards combinations of essential micronutrients at doses below upper tolerable levels. Finally, the time of high-dose micronutrient monotherapy is probably over.

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“…The potential use of nutritional treatments as additional therapy to improve recovery and lessen the severity of pneumonia in pediatric patients has drawn interest. Zinc and vitamin A are two micronutrients that have come to light as viable options with immunomodulatory qualities that may influence the development of pediatric CAP [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Efficacy of Zinc and Vitamin A in Treating Pediatric Community-Acquired Pneumonia

Atta,

Aftab,

Shafqat

et al. 2024

Cureus

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Background: Community-acquired pneumonia (CAP) poses a significant global health challenge, even more so for children less than five years old. Nutritional interventions, such as zinc and vitamin A supplementation, are gaining attention for their therapeutic potential in enhancing recovery and minimizing pneumonia severity in pediatric patients. Objective: To assess the therapeutic benefits of zinc and vitamin A supplementation in pediatric CAP patients under five years old and to advocate for their use in clinical settings. Methodology: Three groups were formed in a randomized controlled trial conducted from October 2022 to September 2023, to address zinc and vitamin A supplementation in pediatric patients under five years old in the intensive care unit with severe pneumonia. Group 1 received zinc supplementation, group 2 received vitamin A supplementation, and group 3 served as the control group, receiving antibiotic treatment exclusively for pneumonia. This treatment comprised either a β-lactam (amoxicillin-clavulanate, commonly referred to as Augmentin) administered orally at 500 mg/125 mg three times a day, Augmentin 875 mg/125 mg orally twice daily, or Augmentin 2000 mg/125 mg orally once daily. Additionally, the control group received a macrolide (azithromycin or clarithromycin) or doxycycline at a dosage of 100 mg orally twice daily. Linear regression analysis identified statistically significant decreases in both length of hospital stay and active pneumonic effusion. Results: The study encompassed 90 pediatric pneumonia patients with an age range of six to 55 months. Multiple linear regression analysis showed that both vitamin A and zinc led to a significant decrease in hospitalization length by 2.39 days (p < 0.01, 95% CI: 4.19-0.47) and 3.17 days (p < 0.01, 95% CI: 5.19-1.31), respectively. In comparison to the control group, both the vitamin A and zinc supplementation groups were linked to a shorter pneumonic effusion duration (p < 0.001). Conclusion: Both interventions significantly reduced the duration of hospitalization (2.39 days for vitamin A and 3.17 days for zinc) and pneumonic effusion compared to the control group. These findings highlight the potential of zinc and vitamin A as valuable additions to standard CAP treatment regimens, potentially leading to improved clinical outcomes and reduced healthcare burdens.

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Effect of zinc versus vitamin A supplementation on pediatric patients with community-acquired pneumonia

Cited by 7 publications

References 53 publications

The Relationship Between Dyspnea Severity with Radiological and Laboratory Findings in Pneumonia in Children in Pediatric Palliative Care

The Relationship Between Dyspnea Severity with Radiological and Laboratory Findings in Pneumonia in Children in Pediatric Palliative Care

An update on essential micronutrients in critical illness

Investigating the Efficacy of Zinc and Vitamin A in Treating Pediatric Community-Acquired Pneumonia

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