Abstract:Background: Post-transplant immune reconstitution has a significantly effect on "hematopoietic stem cell transplantation (HSCT)" outcomes. Delay in immune reconstitution increases the risk of infections and disease relapse after transplantation. Recovery of T cells is mainly thymus-dependent. Thymic atrophy is associated with various clinical conditions that lead to a reduced thymic output. Therefore, thymus rejuvenation can improve immune reconstitution after transplantation.
Zn plays a pivotal role in thymu… Show more
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