Effect of Vitamins C and E Co-Supplementation on Serum C-Reactive Protein Level: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Fouladvand, Faezeh; Falahi, Ebrahim; Asbaghi, Omid; Abbasnezhad, Amir

doi:10.3746/pnf.2020.25.1.1

Cited by 11 publications

(8 citation statements)

References 44 publications

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“…In agreement with our data, anti‐inflammatory diets rich in omega‐3 polyunsaturated fatty acids have been proposed as potential treatments for NAFLD because they might enhance hepatic β‐oxidation, decrease endogenous lipid production, and reduce the expression of pro‐inflammatory molecules and oxygen reactive species 31 . Interestingly, the results of a randomised double‐blind placebo‐controlled trial demonstrated that a combined treatment with α‐tocopherol (vitamin E) and vitamin C, which are potent antioxidants with anti‐inflammatory properties, 32 resulted in a significant improvement in the fibrosis scores of participants after 6 months of therapy 33 . Additionally, flavonoids, which act as potent antioxidants, have been shown to exert beneficial effects against NAFLD 34 .…”

Section: Discussionmentioning

confidence: 99%

The Dietary Inflammatory Index and hepatic health in the US adult population

Ramírez‐Vélez

García-Hermoso

Izquierdo

et al. 2021

J Human Nutrition Diet

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Background: There is limited evidence on the role of an anti-/pro-inflammatory diet in the prevention of non-alcoholic fatty liver disease (NAFLD). We aimed (i) to assess the anti-inflammatory diet profile and its association with transient elastography parameters, including liver stiffness measurement (LSM) and controlled attenuation parameter (CAP), and (ii) to analyse the relationship between the anti-inflammatory diet and surrogate markers of liver disease in a multiethnic US population. Methods: A cross-sectional study was conducted on a nationally representative population of 4189 US adults aged 20-80 years. A FibroScan ® 502 V2 device (Echosens) was used to estimate the CAP and LSM. Liver markers, including the aspartate transaminase (AST) to alanine transaminase (ALT) ratio, fatty liver index (FLI) and fibrosis-4 score, were also calculated. The Dietary Inflammatory Index (DII) was calculated using a 24-h diet recall. Results: Lower DII scores (anti-inflammatory diet) were associated with a lower AST:ALT ratio (p < 0.001) and FLI (p < 0.036) after adjusting for covariates. Linear regression analysis revealed that gamma-glutamyl transferase levels (β = 1.702, 95% confidence interval [CI] = 0.325-3.080, p = 0.015), ALT levels (β = −0.616, 95% CI = −1.097 to −0.135, p = 0.012), AST:ALT ratio (β = 0.025, 95% CI = 0.014-0.036, p < 0.001) and FLI (β = 1.168, 95% CI = 0.224-2.112, p = 0.015) were significantly associated with the DII in the multivariable-adjusted model. Participants in the highest anti-inflammatory tertile had the lowest odds ratio (OR) for NAFLD assessed by FLI in both unadjusted (OR = 0.652, 95% CI = 0.539-0.788, p ≤ 0.001) and adjusted models (OR = 0.722, 95% CI = 0.537-0.972, p = 0.032). For the transient elastography parameters (LSM and CAP), no significant associations were identified. Conclusions: There was no relationship between the transient elastography parameters and the anti-inflammatory diet profile, although our study showed an association between higher pro-inflammatory properties of diet and poorer hepatic health assessed by surrogate markers of liver disease. Therefore, strategies to promote an anti-inflammatory diet should be considered to prevent NAFLD in adults.

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Section: Discussionmentioning

confidence: 99%

The Dietary Inflammatory Index and hepatic health in the US adult population

Ramírez‐Vélez

García-Hermoso

Izquierdo

et al. 2021

J Human Nutrition Diet

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“…Another study has investigated the pleiotropic effects of ASC on cardiovascular health parameters including blood pressure, lipid profiles, arterial stiffness, and endothelial function [179]. According to a meta-analysis of randomized controlled trials, published in 2015, the oral administration of several natural antioxidant molecules including ASC reduced arterial stiffness and enhanced endothelial function [180]. It has also been demonstrated that supplementation with ASC and tocopherols improved endothelial function, although these effects did not extend to cholesterol or triglyceride metabolism [181] (Table 6).…”

Section: Cardioprotective and Vasculoprotective Properties Of Ascmentioning

confidence: 99%

Multiple Effects of Ascorbic Acid against Chronic Diseases: Updated Evidence from Preclinical and Clinical Studies

et al. 2020

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Severe disease commonly manifests as a systemic inflammatory process. Inflammation is associated withthe enhanced production of reactive oxygen and nitrogen species and with a marked reduction in the plasma concentrations of protective antioxidant molecules. This imbalance gives rise to oxidative stress, which is greater in patients with more severe conditions such as sepsis, cancer, cardiovascular disease, acute respiratory distress syndrome, and burns. In these patients, oxidative stress can trigger cell, tissue, and organ damage, thus increasing morbidity and mortality. Ascorbic acid (ASC) is a key nutrient thatserves as an antioxidant and a cofactor for numerous enzymatic reactions. However, humans, unlike most mammals, are unable to synthesize it. Consequently, ASC must be obtained through dietary sources, especially fresh fruit and vegetables. The value of administering exogenous micronutrients, to reestablish antioxidant concentrations in patients with severe disease, has been recognized for decades. Despite the suggestion that ASC supplementation may reduce oxidative stress and prevent several chronic conditions, few large, randomized clinical trials have tested it in patients with severe illness. This article reviews the recent literature on the pharmacological profile of ASC and the role of its supplementation in critically ill patients.

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“…Supplementation of VC and VE has been shown to be useful in preventing bone loss linked to oxidative stress in the elderly (53) . A recent meta-analysis also indicated beneficial effects of VC and VE co-supplementation on serum C-reactive protein (CRP), an important biomarker for predicting diseases, in participants ≥ 30 years of age but not in young subjects (54) . Further, a randomized clinical trial showed that co-administration of VC and VE may improve arterial blood gas parameters and reduce intensive care unit stay in patients with lung contusion (55) .…”

Section: Discussionmentioning

confidence: 99%

Determination of tissue-specific interaction between vitamin C and vitamin Ein vivousing senescence marker protein-30 knockout mice as a vitamin C synthesis deficiency model

et al. 2021

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Vitamin E (α-tocopherol; VE) is known to be regenerated from VE radicals by vitamin C (L-ascorbic acid; VC) in vitro. However, their in vivo interaction in various tissues is still unclear. Therefore, we alternatively examined the in vivo interaction of VC and VE by measurement of their concentrations in various tissues of senescence marker protein-30 (SMP30) knockout (KO) mice as a VC synthesis deficiency model. Male SMP30-KO mice were divided into four groups (VC+/VE+, VC+/VE–, VC–/VE+ and VC–/VE–), fed diets with or without 500 mg/kg VE and given water with or without 1·5 g/l VC ad libitum. Then, VC and VE concentrations in the plasma and various tissues were determined. Further, gene expression levels of transporters associated with VC and VE, such as α-tocopherol transfer protein (α-TTP) and sodium-dependent vitamin C transporters (SVCTs), were examined. These results showed that the VE levels in the VC-depleted (VC–/VE+) group were significantly lower than those in the VC+/VE+ group in the liver and heart; the VC levels in the VE-depleted (VC+/VE–) group were significantly lower than those in the VC+/VE+ group in the kidneys. The α-TTP gene expression in the liver and kidneys was decreased by VC and/or VE depletion. Moreover, SVCT1 gene expression in the liver was decreased by both VC and VE depletion. In conclusion, these results indicate that VC spares VE mainly in the liver and heart and that VE spares VC in the kidneys of SMP30-KO mice. Thus, interaction between VC and VE is likely to be tissue specific.

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Effect of Vitamins C and E Co-Supplementation on Serum C-Reactive Protein Level: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Cited by 11 publications

References 44 publications

The Dietary Inflammatory Index and hepatic health in the US adult population

The Dietary Inflammatory Index and hepatic health in the US adult population

Multiple Effects of Ascorbic Acid against Chronic Diseases: Updated Evidence from Preclinical and Clinical Studies

Determination of tissue-specific interaction between vitamin C and vitamin Ein vivousing senescence marker protein-30 knockout mice as a vitamin C synthesis deficiency model

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