Effect of ultrasound on the kinetics of anti-solvent crystallization of sucrose

Zhong, Xuwei; Huang, Chengdu; Chen, Lishan; Yang, Qinghong; Huang, Yudong

doi:10.1016/j.ultsonch.2021.105886

Cited by 23 publications

(15 citation statements)

References 30 publications

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“…The authors hypothesize that lower ultrasonic energies destroy the formation of subnuclei in solution, while higher ultrasonic energies increase intermolecular collisions and promote the agglomeration of these clusters beyond the critical nucleation radius. Zhong et al 98 studied the effect of ultrasound on the kinetics of sucrose antisolvent crystallization, and the results showed that when the ultrasound power is <72 W, the cavitation effect makes the nucleation play a dominant role. When the ultrasonic power is >72 W, the researchers believe that it may be due to the high viscosity of sucrose, which weakens the cavitation effect, thereby reducing the nucleation rate, increasing the growth rate, and obtaining crystals with larger particle sizes.…”

Section: Physical Fields To Inhibitmentioning

confidence: 99%

Inhibition of Crystal Nucleation and Growth: A Review

Zhang,

Li,

Liu

et al. 2024

Crystal Growth & Design

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The formation of crystalline materials typically follows the nucleation and crystal growth pathway, which enables scientists to engineer crystal properties, and the metastable status that exists before nucleation plays a decisive role in affecting the feasibility of crystallization. Over the past decade, there has been significant interest in stabilizing metastable states, such as amorphous structures, metastable polymorphism, and supersaturated solutions, which requires the inhibition of crystal nucleation and growth. Based on the theories of crystal nucleation and growth, this paper provides a comprehensive review of molecular-scale inhibition techniques and their corresponding mechanisms. Nature additives and tailored additives are the most important methods for modulating molecular assembly, which can be scanned or designed following the principles of molecular interactions and docking. Confining molecules within nanometric spaces such as nano-or microporous materials or artificial interfaces can hinder the motions of molecules, thus affecting nucleation. Additionally, physical fields including magnetic, ultrasonic, and electric fields are reviewed in comparison of the acceleration and inhibition of nucleation. Furthermore, we summarize the application scenarios where inhibiting nucleation and crystal growth is essential across various domains including pharmaceuticals, biominerals, ice crystallization, etc. Lastly, research and application prospects are proposed for further exploration of the inhibition of crystal nucleation and growth.

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Section: Physical Fields To Inhibitmentioning

confidence: 99%

Inhibition of Crystal Nucleation and Growth: A Review

Zhang,

Li,

Liu

et al. 2024

Crystal Growth & Design

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“…This is because the local high temperature induced by ultrasound increased the probability of particle redissolution and then recrystallization growth on the existing crystals. Furthermore, in sucrose anti-solvent crystallization, Zhong et al 59 found that the ultrasonic field did not affect the shape of the sucrose crystal, whereas it affected the particle size. Further exploration showed that when the ultrasonic power was lower than 72 W, nucleation played a dominant role owing to the cavitation effect.…”

Section: Intensification Of Crystal Growthmentioning

confidence: 99%

Recent progress on strategies for the enhancement of crystal growth process

Zhao

Wang

et al. 2023

CrystEngComm

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“…Numerous studies have reported beneficial results with the assistance of ultrasound in the crystallization process. Ultrasound can promote nucleation, 15 narrow particle size distribution, 16,17 decrease agglomeration, 18 control polymorphs, and accelerate polymorphic transformation. [19][20][21] The benefits that can be obtained by the application of ultrasound in crystallization depend on different operating parameters such as the frequency of irradiation, power dissipation, time of ultrasound application, and the type of reactor.…”

Section: Introductionmentioning

confidence: 99%