Effect of type 2 diabetes on plasma kallikrein activity after physical exercise and its relationship to post-exercise hypotension

Motta, Daisy Fonseca; Lima, Luciano Ramos de; Arsa, Gisela; Russo, Paulo; Sales, Marcelo Magalhães; Moreira, Sérgio Rodrigues; Morais, Pâmella Karoline de; Almeida, Wesley Salazar; Araújo, Ronaldo Carvalho; Moraes, Milton Rocha; Pesquero, Jorge Luiz; Simões, Herbert Gustavo; Campbell, Carmen Silvia Grubert

doi:10.1016/j.diabet.2010.03.008

Cited by 27 publications

(41 citation statements)

References 24 publications

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“…2,5,24 Attempting to demonstrate the relevance of PEH for the treatment of hypertensive individuals, some criteria such as the magnitude of BP reduction, the duration of PEH and its occurrence outside of the laboratory have been investigated. [1][2][3]10 Here we evaluated the PEH of hypertensive individuals before and after 12 weeks of a moderate-intensity RET program. Our primary new finding is that stage 1 hypertensives submitted to an acute experimental resistance exercise bout show attenuated PEH after the 12-week RET program.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Most previous studies regarding PEH have been performed with an aerobic exercise design. 3,4 However, resistance exercise training (RET) is also considered as an important contribution to exercise training programs for hypertensive individuals. [5][6][7][8] PEH could be clinically relevant, because it would mantain BP of hypertensinve individuals transiently at lower levels during day-time intervals, when BP is typically at its highest levels.…”

Section: Introductionmentioning

confidence: 99%

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Effect of 12 weeks of resistance exercise on post-exercise hypotension in stage 1 hypertensive individuals

et al. 2011

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Post-exercise hypotension (PEH), the reduction of blood pressure (BP) after a single bout of exercise, is of great clinical relevance. As the magnitude of this phenomenon seems to be dependent on pre-exercise BP values and chronic exercise training in hypertensive individuals leads to BP reduction; PEH could be attenuated in this context. Therefore, the aim of the present study was to investigate whether PEH remains constant after resistance exercise training. Fifteen hypertensive individuals (46±8 years; 88±16 kg; 30±6% body fat; 150± 13/93±5 mm Hg systolic/diastolic BP, SBP/DBP) were withdrawn from medication and performed 12 weeks of moderate-intensity resistance training. Parameters of cardiovascular function were evaluated before and after the training period. Before the training program, hypertensive volunteers showed significant PEH. After an acute moderate-intensity resistance exercise session with three sets of 12 repetitions (60% of one repetition maximum) and a total of seven exercises, BP was reduced post-exercise (45-60 min) by an average of aproximately À22 mm Hg for SBP, À8 mm Hg for DBP and À13 mm Hg for mean arterial pressure (Po0.05). However, this acute hypotensive effect did not occur after the 12 weeks of training (P40.05). In conclusion, our data demonstrate that PEH, following an acute exercise session, can indeed be attenuated after 12 weeks of training in hypertensive stage 1 patients not using antihypertensive medication.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of 12 weeks of resistance exercise on post-exercise hypotension in stage 1 hypertensive individuals

et al. 2011

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“…The interest stems from the fact that excess CO 2 production is a hallmark of metabolic acidosis and was linked to a number of pathologies [4][5][6][7]. However, results linking type 2 diabetes and amount of excess post-exercise CO 2 are very limited and related to anaerobic threshold (AT) only [8][9][10][11]. Abnormal respiratory exchange has been reported in women with type 2 diabetes mellitus [8], specifically, their CO 2 kinetics was slower than controls.…”

Section: Introductionmentioning

confidence: 99%

Kinetics of Post-Exercise Excess CO2 Production and Substrate Oxidation in Two Dysglycemic and Euglycemic Older Women A Case Study.

Gribok¹,

Rumpler²,

DiPietro³

2017

Diabetes Case Rep

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“…The PEH is evidenced after different stimuli, as seen in studies that used aerobic exercise 1 or resistance exercise 3,4 , both in male 5 and female6 subjects and different. However, most of the researches is targeted to middle-aged and elderly people [7][8][9] and who have some pathology, such as hypertension 10,11 , diabetes mellitus 12,13 or chronic kidney disease 14 . This tendency is associated with the fact that the PEH is currently considered a pivotal non pharmacological treatment of hypertension 15,16 , since the individuals with hypertension are at high risk of coronary heart disease, stroke and kidney diseases 17 .…”

Section: Introductionmentioning

confidence: 99%

Post-exercise hypotension of normotensive young men through track running sessions

Pardono

Fernandes

Azevêdo

et al. 2015

Rev Bras Med Esporte

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INTRODUCTION: After a single session of physical exercise the blood pressure is reduced (post-exercise hypotension, PHE) and it has been considered as a non-pharmacological mechanism to control the blood pressure. When the exercise is performed since youth it can prevent or avoid hypertension. However, it is important to consider studies with clear practical applications to optimize its reproducibility on a daily basis. OBJECTIVE: Analyze the PEH of normotensive and physically active young men after two track running sessions (maximum and submaximal). METHODS: Participated in this study 62 physically active young men (23.3 ± 4.2 years old; 75.5 ± 9.8 kg; 177.7 ± 5.5 cm; 12.0 ± 4.6% body fatF; 52.4 ± 4.0 mL.kg-1.min-1oxygen uptake), which performed a maximum laboratory exercise test for determination of maximal oxygen uptake (VO2max - aerobic power) and subsequently three randomly running sessions (maximum - T1600; submaximal - T20; control - CON), with 48h interval between themselves. Blood pressure (BP) was measured each 15min during a 60 min period after sessions. RESULTS: Both the maximum and the submaximal exercise lead to PEH. The post-exercise values of systolic blood pressure and diastolic blood pressure differed from resting value in session T20 (p<0.05). The same pattern occurred after T1600 (p<0.05), evidenced from 30th minute post-exercise. The CON did not result in PEH. The magnitude of decay for the mean BP at the 45th after maximum exercise was higher than the other sessions (p<0.05). CONCLUSION: We concluded that both maximum and submaximal exercises, performed on a track running condition, caused PEH in young normotensive and physically active men.

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Effect of type 2 diabetes on plasma kallikrein activity after physical exercise and its relationship to post-exercise hypotension

Cited by 27 publications

References 24 publications

Effect of 12 weeks of resistance exercise on post-exercise hypotension in stage 1 hypertensive individuals

Effect of 12 weeks of resistance exercise on post-exercise hypotension in stage 1 hypertensive individuals

Kinetics of Post-Exercise Excess CO2 Production and Substrate Oxidation in Two Dysglycemic and Euglycemic Older Women A Case Study.

Post-exercise hypotension of normotensive young men through track running sessions

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