2020
DOI: 10.1101/2020.04.26.062505
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Effect of tryptophan depletion on conditioned threat memory expression: role of intolerance of uncertainty

Abstract: BackgroundResponding emotionally to danger is critical for survival. Normal functioning also requires flexible alteration of emotional responses when a threat becomes safe. Aberrant threat and safety learning occurs in many psychiatric disorders including post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and schizophrenia, where emotional responses can persist pathologically. Whilst there is evidence that threat and safety learning can be modulated by the serotonin systems, there have… Show more

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Cited by 3 publications
(6 citation statements)
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References 44 publications
(69 reference statements)
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“…'Cold' cognition Our results showed no significant effects on any measures of 'cold' cognition, thus contrasting with some of our previous data obtained following acute administration [20]. Previous studies manipulating serotonin acutely have shown alterations in both 'cold' and 'hot' cognitive measures [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. However, it is important to note that our study examined SSRI administration over a longer time period, which has not previously been much studied in the context of human cognition.…”
Section: Reinforcement Behaviourcontrasting
confidence: 99%
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“…'Cold' cognition Our results showed no significant effects on any measures of 'cold' cognition, thus contrasting with some of our previous data obtained following acute administration [20]. Previous studies manipulating serotonin acutely have shown alterations in both 'cold' and 'hot' cognitive measures [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. However, it is important to note that our study examined SSRI administration over a longer time period, which has not previously been much studied in the context of human cognition.…”
Section: Reinforcement Behaviourcontrasting
confidence: 99%
“…In humans, the modulatory effects of serotonin on cognition have largely been examined through acute dietary tryptophan depletion (ATD) [8][9][10][11][12][13][14][15][16][17][18], or through acute SSRI administration [19][20][21][22][23]. ATD has been shown to affect measures of both 'cold' (rational and non-emotional), and 'hot' (social and emotional) cognition [13][14][15][16][17][18].…”
Section: Introductionmentioning
confidence: 99%
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“…In keeping with a variety of metrics used in the literature to capture the process of threat extinction (57) While there is some interdependence between the different SCR difference scores, organising the SCR data in this manner allows for the assessment of threat and safety discrimination overall, and across time (57). For 4 experiments, only the early extinction training metric was analysed (64,65,69,70). This was due to these studies having too few extinction learning trials to examine SCR across the whole phase, during late extinction, and comparing early versus late extinction (i.e., the studies only had 9 or 10 total trials per CS type).…”
Section: Scrmentioning
confidence: 99%