Effect of Transosseous Application of Low-Intensity Ultrasound at the Tendon Graft-Bone Interface Healing: Gene Expression and Histological Analysis in Rabbits

Papatheodorou, Loukia K.; Malizos, Konstantinos N.; Poultsides, Lazaros; Hantes, Michael; Grafanaki, Katerina; Giannouli, Stamatina; Ιωάννου, Μαρία; Koukoulis, G.; Protopappas, Vasilios C.; Fotiadis, Dimitrios I.; Stathopoulos, Constantinos

doi:10.1016/j.ultrasmedbio.2008.07.003

Cited by 22 publications

(11 citation statements)

References 39 publications

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“…The authors found that LIPUS increased osteoid thickness, mineral apposition rate and bone volume at the front of new bony callus formation, which indicated increased osteoblast activity. Other authors have reported accelerated healing of articular cartilage (Jai et al 2005) and tendon graft-bone interface (Papatheodorou et al 2009) in rabbit models. Few studies, however, have investigated the effects of LIPUS on the differentiation of human MSCs (hMSCs).…”

Section: Discussionmentioning

confidence: 92%

“…Early studies have shown that LIPUS can accelerate bone healing in animal models (Pilla et al 1990) and in humans (Heckmann et al 1994). Recent studies continue to confirm the positive effects of LIPUS on healing of bone (Esteki et al 2010;Rutten et al 2008), articular cartilage (Jia et al 2005) and the tendon graft-bone interface (Papatheodorou et al 2009). Few studies, however, have investigated the effects of LIPUS on the differentiation of human mesenchymal stem cells (hMSCs).…”

Section: Introductionmentioning

confidence: 97%

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Effects of Low-Intensity Pulsed Ultrasound, Dexamethasone/TGF-β1 and/or BMP-2 on the Transcriptional Expression of Genes in Human Mesenchymal Stem Cells: Chondrogenic vs. Osteogenic Differentiation

Lai

Chen

Chiu

et al. 2010

Ultrasound in Medicine & Biology

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 97%

Effects of Low-Intensity Pulsed Ultrasound, Dexamethasone/TGF-β1 and/or BMP-2 on the Transcriptional Expression of Genes in Human Mesenchymal Stem Cells: Chondrogenic vs. Osteogenic Differentiation

Lai

Chen

Chiu

et al. 2010

Ultrasound in Medicine & Biology

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“…The modulation of Bgn gene expression has been proposed to represent a mechanism to counteract mineralized bone loss under conditions of estrogen depletion (67). Trans-osseous application of low-intensity ultrasound at the tendon graft-bone healing interface stimulated endogenous expression of Bgn and collagen I, thereby enhancing tendon-bone healing (93). The above studies support utilization of biglycan therapy as a credible therapeutic venue to reduce or block degenerative bone diseases.…”

Section: Potential Therapeutic Agents For Bone Diseasesmentioning

confidence: 84%

The Biology of Small Leucine-rich Proteoglycans in Bone Pathophysiology

Nikitovic

Aggelidakis

Young

et al. 2012

Journal of Biological Chemistry

131

122

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The class of small leucine-rich proteoglycans (SLRPs) is a family of homologous proteoglycans harboring relatively small (36 -42 kDa) protein cores compared with the larger cartilage and mesenchymal proteoglycans. SLRPs have been localized to most skeletal regions, with specific roles designated during all phases of bone formation, including periods relating to cell proliferation, organic matrix deposition, remodeling, and mineral deposition. This is mediated by key signaling pathways regulating the osteogenic program, including the activities of TGF-␤, bone morphogenetic protein, Wnt, and NF-B, which influence both the number of available osteogenic precursors and their subsequent development, differentiation, and function. On the other hand, SLRP depletion is correlated with degenerative diseases such as osteoporosis and ectopic bone formation. This minireview will focus on the SLRP roles in bone physiology and pathology.

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“…43 Similarly, there was up-regulation of type I collagen gene expression with LITUS treatment compared to controls. 44 Additionally, in procedures replacing ligaments with tendons (i.e., anterior cruciate ligament surgery; ACL), LITUS treated tendons showed greater stiffness and peak load compared to controls. 36,40,45 …”

Section: Resultsmentioning

confidence: 99%

Low Intensity Ultrasound for Promoting Soft Tissue Healing: A Systematic Review of the Literature and Medical Technology

Best

Wilk

Moorman

et al. 2016

IMRJ

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Therapeutic ultrasound has been studied and used for the past seven decades to treat musculoskeletal injuries. Recently, a significant body of animal and human research has focused on the biomechanical effects of daily-applied, low intensity therapeutic ultrasound (LITUS) on soft tissue recovery. We performed a systematic review of the last two decades of LITUS literature to examine the effects on tendon, skeletal muscle, ligament, and tendon-bone junction injuries. LITUS facilitated tendon healing, with increased tensile strength and improved collagen alignment. For skeletal muscle and ligament injuries, LITUS increased cell proliferation during myoregeneration and improved tissue biomechanics (ultimate load, stiffness, energy absorption). LITUS aided tendon-bone junction healing through improved tissue function. Scientific evidence supports the use of LITUS to treat soft tissue injuries, and improve outcomes for musculoskeletal injuries and post-operative recovery. Lastly, we discuss the use of LITUS devices facilitating daily applied therapy in the home setting.

show abstract

Effect of Transosseous Application of Low-Intensity Ultrasound at the Tendon Graft-Bone Interface Healing: Gene Expression and Histological Analysis in Rabbits

Cited by 22 publications

References 39 publications

Effects of Low-Intensity Pulsed Ultrasound, Dexamethasone/TGF-β1 and/or BMP-2 on the Transcriptional Expression of Genes in Human Mesenchymal Stem Cells: Chondrogenic vs. Osteogenic Differentiation

Effects of Low-Intensity Pulsed Ultrasound, Dexamethasone/TGF-β1 and/or BMP-2 on the Transcriptional Expression of Genes in Human Mesenchymal Stem Cells: Chondrogenic vs. Osteogenic Differentiation

The Biology of Small Leucine-rich Proteoglycans in Bone Pathophysiology

Low Intensity Ultrasound for Promoting Soft Tissue Healing: A Systematic Review of the Literature and Medical Technology

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