1972
DOI: 10.1172/jci107119
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Effect of transfer factor on lymphocyte function in anergic patients

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1972
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Cited by 143 publications
(27 citation statements)
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References 32 publications
(31 reference statements)
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“…However, transfer factor activity in the whole dialysates was demonstrated by conversion of delayed cutaneous hypersensitivity responses in patients with cellular immune deficiencies as described previously (1).…”
Section: Introductionmentioning
confidence: 83%
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“…However, transfer factor activity in the whole dialysates was demonstrated by conversion of delayed cutaneous hypersensitivity responses in patients with cellular immune deficiencies as described previously (1).…”
Section: Introductionmentioning
confidence: 83%
“…After receiving transfer factor, anergic patients with chronic mucocutaneous candidiasis (1), coccidioidomycosis (2), or the Wiskott-Aldrich syndrome (3) developed positive delayed cutaneous hypersensitivity responses, and in some cases their lymphocytes responded to antigenic stimulation in vitro with lymphokine production (1)(2)(3). Others have reported that after administration of transfer factor from specificially reactive donors, patients with osteogenic sarcoma developed cell-mediated cytotoxicity (4), and that lymphocytes from a patient with alveolar softpart sarcoma responded in vitro to an extract of the tumor with production of migration inhibitory factor (5).…”
Section: Introductionmentioning
confidence: 99%
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“…A partially purified preparation of transfer factor was obtained by disruption of 3 X 10' small lymphocytes by freezing and thawing, digestion with pancreatic deoxyribonuclease, and dialysis against pyrogen-free glassdistilled water for 48 h at 4°C (16). The dialysate was then fractionated by Sephadex G-25 gel filtration, as previously reported (4), and the column fractions containing both chemotactic factor and transfer factor activity were used.…”
Section: Introductionmentioning
confidence: 99%
“…This is an extract of lymphocytes, whose exact chemical nature and way of operating is still obscure. It is essential in this context that the transfer factor derives from persons with a strong allergy to Candida (Kirkpatrick, Rich and Smith, 1972). Amount and dosage schedules vary from study to study and so do the results.…”
Section: Man Lives In a Delicate Balance With Candidamentioning
confidence: 99%