Effect of tranexamic acid on post partum hemorrhage by uterine atony: A preliminary result of a randomized, placebocontrolled trial

Ayedi, M.; Jarraya, A.; Smaoui, M.; Zouari, J.; Smaoui, L.; Kolsi, K.

doi:10.1097/00003643-201106001-00531

Cited by 7 publications

(5 citation statements)

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“…It is consistent with Tunisian preliminary study showing 20% patient requiring blood transfusion after TXA administration [1]. Even number of units of blood transfusion was significantly lower in TXA group (0.286 unit) than control group (1.286 unit) [p=0.001].Similar results were also obtained in trial by Ayedi M et al in 2011 [15]. Blood is a scarce and costly resource and blood transfusion has several rare but serious adverse effects.…”

Section: Observation and Resultssupporting

confidence: 88%

“…In RCT conducted by Ducloy-Bouthers et al, invasive procedures were performed in 4 women in TXA group and in 7 women in controls (P=NS) [13]. In another study done by Ayedi M et al, no significant difference was found regarding invasive procedures in TXA and placebo group [15].…”

Section: Observation and Resultsmentioning

confidence: 99%

“…The protocol succeeded in 80% of the cases [1]. Ayedi M et al in another study in Tunisia used TXA in atonic PPH following Caesaeian section after inefficacy of oxytocin injection and found that TXA safely reduced blood transfusions, duration of hospitalization, arterial ligation and hysterectomy [15] .…”

Section: Observation and Resultsmentioning

confidence: 99%

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Efficacy of Tranexamic Acid in Combination With Conventional Therapy for Treatment of Pph

Hamid

Begum

2016

J Chittagong Med Coll Teachers Ass

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Haemorrhage is the leading cause of maternal mortality, accounting for about 35% of all maternal deaths. About 14 million women around the world suffer from Post Partum Hemorrhage (PPH) every year. Of them, about 2% die with an average interval of 2-4 hrs from onset of bleeding. Tranexamic Acid (TXA) is the most effective of the available anti-fibrinolytics, which has been shown to be very useful in reducing blood loss and incidence of blood transfusion in different surgeries. The study was done to see the efficacy of injectable tranexamic acid in addition to conventional treatment in control of atonic PPH. In this study, women having atonic PPH following vaginal delivery were grouped into two, A & B. Group A received 2 amp inj.TXA (Tranexamic acid) i.v immediately after diagnosis of PPH and Group B received 10ml distilled water i.v. Both groups received all other necessary measures for control of PPH and outcomes were recorded in a preformed data collection sheet. All data were analyzed by computer based software Statistical Packages for Social Science (SPSS) version 15.The results showed that tranexamic acid significantly reduced the volume of blood loss in atonic PPH, 1141.23±489.91 ml in study group versus 1365.25±428.22 ml in control group.PPH control within 2 hr with medical therapies occurred more in TXA group (88.09%) than in control group (57.14%). Invasive procedures were less required in TXA group than in control group ,condom catheter in 4 pt. (9.52%) compared to 11(26.19%) in control group. Hysterectomy was done in 1 case of TXA group compared to 7 cases of control group. TXA also significantly reduced the necessity of blood transfusion in PPH, 26.19% in TXA group compared to 54.76% in control group. So one gm i.v. tranexamic acid given along with other conventional measures at the diagnosis of atonic PPH significantly reduces the amount of blood loss, requirement of blood transfusion, necessity of invasive procedures. JCMCTA 2015 ; 26 (2) : 34 - 39

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Section: Observation and Resultssupporting

confidence: 88%

Section: Observation and Resultsmentioning

confidence: 99%

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Efficacy of Tranexamic Acid in Combination With Conventional Therapy for Treatment of Pph

Hamid

Begum

2016

J Chittagong Med Coll Teachers Ass

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“…Upon reading the abstracts of the 461 remaining results, only 39 studies were qualified for full text reading. Of these, two were excluded for not having or not reporting randomization, 20 , 21 nine for not using placebo in the control group, 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 four for not having or not reporting blinding, 31 , 32 , 33 , 34 five for not reporting neither blinding nor placebo, 35 , 36 , 37 , 38 , 39 one for using TXA as treatment and not as prophylaxis, 40 and one because only the abstract was written in English. 41 Thus, 17 trials were selected to comprise the systematic review, however, one of them could not be part of the meta-analysis, as the volume measurements did not report standard deviation 42 ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Analysis of the efficacy of prophylactic tranexamic acid in preventing postpartum bleeding: systematic review with meta-analysis of randomized clinical trials

Assis

Govêia

Miranda

et al. 2023

Brazilian Journal of Anesthesiology (English Edition)

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“…The two medications most commonly used for treatment include oxytocin or misoprostol. In addition, patients are commonly given an IV blood transfusion in cases of severe hemorrhage [7,8]. In third world countries, availability of blood and fluid replacement may be an issue.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis and in vitro kinetic study of tranexamic acid prodrugs for the treatment of bleeding conditions

Ghareeb

Dajani²,

Scrano

et al. 2013

J Comput Aided Mol Des

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Based on density functional theory (DFT) calculations for the acid-catalyzed hydrolysis of several maleamic acid amide derivatives four tranexamic acid prodrugs were designed. The DFT results on the acid catalyzed hydrolysis revealed that the reaction rate-limiting step is determined on the nature of the amine leaving group. When the amine leaving group was a primary amine or tranexamic acid moiety, the tetrahedral intermediate collapse was the rate-limiting step, whereas in the cases by which the amine leaving group was aciclovir or cefuroxime the rate-limiting step was the tetrahedral intermediate formation. The linear correlation between the calculated DFT and experimental rates for N-methylmaleamic acids 1-7 provided a credible basis for designing tranexamic acid prodrugs that have the potential to release the parent drug in a sustained release fashion. For example, based on the calculated B3LYP/6-31G(d,p) rates the predicted t1/2 (a time needed for 50 % of the prodrug to be converted into drug) values for tranexamic acid prodrugs ProD 1-ProD 4 at pH 2 were 556 h [50.5 h as calculated by B3LYP/311+G(d,p)] and 6.2 h as calculated by GGA: MPW1K), 253 h, 70 s and 1.7 h, respectively. Kinetic study on the interconversion of the newly synthesized tranexamic acid prodrug ProD 1 revealed that the t1/2 for its conversion to the parent drug was largely affected by the pH of the medium. The experimental t1/2 values in 1 N HCl, buffer pH 2 and buffer pH 5 were 54 min, 23.9 and 270 h, respectively.

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Effect of tranexamic acid on post partum hemorrhage by uterine atony: A preliminary result of a randomized, placebocontrolled trial

Cited by 7 publications

References 1 publication

Efficacy of Tranexamic Acid in Combination With Conventional Therapy for Treatment of Pph

Efficacy of Tranexamic Acid in Combination With Conventional Therapy for Treatment of Pph

Analysis of the efficacy of prophylactic tranexamic acid in preventing postpartum bleeding: systematic review with meta-analysis of randomized clinical trials

Design, synthesis and in vitro kinetic study of tranexamic acid prodrugs for the treatment of bleeding conditions

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