Effect of Topical Flavonoid Fraction From Artemisia Annua in Comparison With Tacrolimus on Induced Atopic Dermatitis in Mice

Hameed, Mohammed F; Abu-Raghif, Ahmed R.; Kadhim, Enas Jawad

doi:10.22578/ijms.17.3-4.10

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…Both norfloxacin ointment products were administered topically to the hand adjacent to the wrist in a 2 in. 2 area and inspected for any possible lesions, irritation, burning, or erythema. − …”

Section: Methodsmentioning

confidence: 99%

“…People suffering from psoriasis are more likely to have complications that are not limited to skin conditions. These encompass type 2 diabetes, obesity, coronary artery diseases, autoimmune diseases, and psychiatric issues. − There is more evidence that psoriasis may arise simultaneously or consecutively with additional immune-mediated skin eruptions, most notably eczematous dermatitis. − Research has also revealed links between psoriasis and an array of immune-associated conditions, among them ulcerated intestinal colitis. − In addition, kidney impairment is known as one of the consequences of psoriasis. − Moreover, arrays of drugs have been significantly implicated in the initiation and aggravation of psoriasis, namely, chloroquine, interferons, imiquimod, tetracyclines, and β-blocking agents …”

Section: Objective Of the Studymentioning

confidence: 99%

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Mitigative Effects of Topical Norfloxacin on an Imiquimod-Induced Murine Model of Psoriasis

Ridha-Salman,

Shihab,

Hasan

et al. 2024

ACS Pharmacol. Transl. Sci.

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Psoriasis is a chronic, inflammatory dermatosis characterized by thickened, reddened, and scaly skin lesions. Norfloxacin is a fluoroquinolone antibiotic with enhanced antioxidant, anti-inflammatory, and immunomodulatory bioactivities. The aim of this study was to figure out the possible impact of topical norfloxacin on an imiquimod-induced model of psoriasis in mice. Thirty albino-type mice were split into five distinct groups of six animals each. The control group included healthy mice that had not received any treatment. The induction group was given the vehicle 2 h after the topical imiquimod, once daily for 8 days. Two hours after receiving topical imiquimod, the treatment groups including calcipotriol, norfloxacin 2.5%, and norfloxacin 5% were given topical ointments containing calcipotriol 0.005%, norfloxacin 2.5%, and norfloxacin 5%, for 8 days. Topical norfloxacin ointment significantly reduced the severity of imiquimod-exacerbated psoriatic lesions including erythema, shiny-white scaling, and acanthosis and fixed histological abnormalities. Furthermore, imiquimod-subjected mice treated with a higher concentration of norfloxacin ointment exhibited dramatically lower skin levels of inflammation-related biomarkers like IFN-γ, TNF-α, IL-6, IL-17A, IL-23, and TGF-β but higher levels of IL-10. They also demonstrated a notable decrease in angiogenesis parameters such as VEGF and IL-8, a substantial reduction in oxidative indicators like MDA and MPO, and a considerable rise in antioxidant enzymes like SOD and CAT. This study offers novel evidence that norfloxacin may assist in controlling inflammatory dermatoses like psoriasis by minimizing the severity of psoriatic plaques, correcting histological alterations, and diminishing the production of inflammatory, oxidative, and angiogenetic parameters.

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Section: Methodsmentioning

confidence: 99%

Section: Objective Of the Studymentioning

confidence: 99%

Mitigative Effects of Topical Norfloxacin on an Imiquimod-Induced Murine Model of Psoriasis

Ridha-Salman,

Shihab,

Hasan

et al. 2024

ACS Pharmacol. Transl. Sci.

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“…Coenzyme Q10-mediated reduction of ROS by activated PC-KUS leads to cessation of depigmentation and repigmentation [ 129 ]. In contrast, researchers in a randomised, single-blind, placebo-controlled trial in Iraq found a significant reduction in the Vitiligo Area Scoring Index after 8 weeks of topical gel application with CoQ10 [ 130 ].…”

Section: Potential Therapeutic Approaches To Reduce Oxidative Stressmentioning

confidence: 99%

Oxidative Stress and Potential Antioxidant Therapies in Vitiligo: A Narrative Review

Białczyk,

Wełniak,

Kamińska

et al. 2023

Mol Diagn Ther

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Vitiligo is a chronic skin disorder characterised by the loss of melanocytes and subsequent skin depigmentation. Although many theories have been proposed in the literature, none alone explains the pathogenesis of vitiligo. Oxidative stress has been identified as a potential factor in the pathogenesis of vitiligo. A growing body of evidence suggests that antioxidant therapies may offer a promising approach to managing this condition. This review summarises the potential mechanisms of oxidative stress and the types of melanocyte death in vitiligo. We also provide a brief overview of the most commonly studied antioxidants. Melanocytes in vitiligo are thought to be damaged by an accumulation of reactive oxygen species to destroy the structural and functional integrity of their DNA, lipids, and proteins. Various causes, including exogenous and endogenous stress factors, an imbalance between prooxidants and antioxidants, disruption of antioxidant pathways, and gene polymorphisms, lead to the overproduction of reactive oxygen species. Although necroptosis, pyroptosis, ferroptosis, and oxeiptosis are newer types of cell death that may contribute to the pathophysiology of vitiligo, apoptosis remains the most studied cell death mechanism in vitiligo. According to studies, vitamin E helps to treat lipid peroxidation of the skin caused by psoralen ultra-violet A treatment. In addition, Polypodium leucotomos increased the efficacy of psoralen ultra-violet A or narrow-band ultraviolet B therapy. Our review provides valuable insights into the potential role of oxidative stress in pathogenesis and antioxidant-based supporting therapies in treating vitiligo, offering a promising avenue for further research and the development of effective treatment strategies.

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“…Hydroquinone (ubiquinol), the reduced form of CoQ10, is a powerful lipophilic antioxidant that can recycle and regenerate other antioxidants like tocopherol and ascorbate. Co Q10 may protect cultured epidermal keratinocytes and dermal fibroblasts from the damaging effects of hydrogen peroxide and ultraviolet A (UVA) [21]. However, there were also reports of negative effects from using topical Co Q10.…”

Section: Skin Absorption and Dispersionmentioning

confidence: 99%

Serum concentrations of Co Q10 and Interleukin-6 in patients with non-segmental Vitiligo

Khammas,

Mikhael,

Abd El-Hassib

et al. 2023

Benha Journal of Applied Sciences

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Background: Vitiligo is a condition where areas of skin lose their pigmentation; oxidative stress and immunological dysregulation have been linked to its development. The purpose of this research was to examine the relationship between Coenzyme Q10 (Co Q10) and in the blood of individuals diagnosed with non-segmental vitiligo. The purpose of this article is to provide readers a thorough introduction to vitiligo, including such topics as the disease's epidemiology, categorization, probable causes, underlying pathogenic processes, diagnostic approaches, and several treatment options. Our goal in compiling this summary is to be a useful tool for clinicians and researchers interested in vitiligo by providing an overview of the current state of knowledge. Conclusions: Because of its complex aetiology, vitiligo is difficult to diagnose and treat. Melanocyte dysfunction is fueled by a complex web of elements including genetic susceptibility, autoimmune processes, oxidative stress, and environmental influences. In order to choose the best course of therapy for vitiligo, the severity and duration of the condition must be evaluated. Treatment for this ailment includes a combination of medicinal, phototherapeutic, and psychosocial approaches. Additional research into the roles of coenzyme Q10 and interleukin-6 in the development of vitiligo is warranted.

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Effect of Topical Flavonoid Fraction From Artemisia Annua in Comparison With Tacrolimus on Induced Atopic Dermatitis in Mice

Cited by 4 publications

References 23 publications

Mitigative Effects of Topical Norfloxacin on an Imiquimod-Induced Murine Model of Psoriasis

Mitigative Effects of Topical Norfloxacin on an Imiquimod-Induced Murine Model of Psoriasis

Oxidative Stress and Potential Antioxidant Therapies in Vitiligo: A Narrative Review

Serum concentrations of Co Q10 and Interleukin-6 in patients with non-segmental Vitiligo

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