Effect of Topical Antibiotic Solutions on Corneal Epithelial Wound Healing

Graft failure: II. Ocular surface complications

“…Examples include topical 5-fluorouracil (FU), mitomycin C (MMC), generic form of nonsteroidal anti-inflammatory drugs (NSAID), aminoglycosides, and trimethoprim sulfate [24,75,76]. In some of these reports this may be related to either preservatives or to a patient selection bias, because patients with epithelial problems may have been more likely to receive prolonged topical drugs.…”

Graft failure: II. Ocular surface complications

“…Examples include topical 5-fluorouracil (FU), mitomycin C (MMC), generic form of nonsteroidal anti-inflammatory drugs (NSAID), aminoglycosides, and trimethoprim sulfate [24,75,76]. In some of these reports this may be related to either preservatives or to a patient selection bias, because patients with epithelial problems may have been more likely to receive prolonged topical drugs.…”

Chloramphenicol induces in vitro growth arrest and apoptosis of human keratinocytes

“…However, some serious systemic sideeffects, such as neutropenia, agranulocytosis, and aplastic anemia have also been observed after topical application of CAP (Fraunfelder et al, 1982). It has been shown that CAP is toxic to corneal cells in vitro and that topically applied CAP may aggravate healing of corneal ulcer (Stern et al, 1983;Berry et al, 1995). The opposite observation, that topically applied CAP may prevent development of corneal ulcers after corneal abrasion (Upadhyay et al, 2001), has been also reported.…”

Benzalkonium Chloride and Gentamicin Cause a Leak in Corneal Epithelial Cell Membrane

“…Most previous research on the effects of topicallyapplied antibiotics and preservatives studied the morphological alteration detected by slip lamp biomicroscope (Stern et al, 1983) or by light or electron microscope (P®ster and Burstein, 1976;Petroutsos et al, 1983). Since morphological changes are usually the result of severe damage, it is less sensitive and speci®c.…”

Graft failure: II. Ocular surface complications

“…Examples include topical 5-fluorouracil (FU), mitomycin C (MMC), generic form of nonsteroidal anti-inflammatory drugs (NSAID), aminoglycosides, and trimethoprim sulfate [24,75,76]. In some of these reports this may be related to either preservatives or to a patient selection bias, because patients with epithelial problems may have been more likely to receive prolonged topical drugs.…”

Chloramphenicol induces in vitro growth arrest and apoptosis of human keratinocytes

“…However, some serious systemic sideeffects, such as neutropenia, agranulocytosis, and aplastic anemia have also been observed after topical application of CAP (Fraunfelder et al, 1982). It has been shown that CAP is toxic to corneal cells in vitro and that topically applied CAP may aggravate healing of corneal ulcer (Stern et al, 1983;Berry et al, 1995). The opposite observation, that topically applied CAP may prevent development of corneal ulcers after corneal abrasion (Upadhyay et al, 2001), has been also reported.…”

Benzalkonium Chloride and Gentamicin Cause a Leak in Corneal Epithelial Cell Membrane

“…Most previous research on the effects of topicallyapplied antibiotics and preservatives studied the morphological alteration detected by slip lamp biomicroscope (Stern et al, 1983) or by light or electron microscope (P®ster and Burstein, 1976;Petroutsos et al, 1983). Since morphological changes are usually the result of severe damage, it is less sensitive and speci®c.…”

Graft failure: II. Ocular surface complications

“…Examples include topical 5-fluorouracil (FU), mitomycin C (MMC), generic form of nonsteroidal anti-inflammatory drugs (NSAID), aminoglycosides, and trimethoprim sulfate [24,75,76]. In some of these reports this may be related to either preservatives or to a patient selection bias, because patients with epithelial problems may have been more likely to receive prolonged topical drugs.…”

Chloramphenicol induces in vitro growth arrest and apoptosis of human keratinocytes

“…However, some serious systemic sideeffects, such as neutropenia, agranulocytosis, and aplastic anemia have also been observed after topical application of CAP (Fraunfelder et al, 1982). It has been shown that CAP is toxic to corneal cells in vitro and that topically applied CAP may aggravate healing of corneal ulcer (Stern et al, 1983;Berry et al, 1995). The opposite observation, that topically applied CAP may prevent development of corneal ulcers after corneal abrasion (Upadhyay et al, 2001), has been also reported.…”

Benzalkonium Chloride and Gentamicin Cause a Leak in Corneal Epithelial Cell Membrane

“…Most previous research on the effects of topicallyapplied antibiotics and preservatives studied the morphological alteration detected by slip lamp biomicroscope (Stern et al, 1983) or by light or electron microscope (P®ster and Burstein, 1976;Petroutsos et al, 1983). Since morphological changes are usually the result of severe damage, it is less sensitive and speci®c.…”