Effect of Topical Agents on Plantar Sweating

Hyperhidrosis plantaris – a randomized, half‐side trial for efficacy and safety of an antiperspirant containing different concentrations of aluminium chloride

“…The pH‐value of the soles was at no point, however, outside the physiological range. The present results confirm previous studies and case series on aluminium salts for focal hyperhidrosis [21, 22, 23, 24, 25]. Both evaluated concentrations are equally efficacious and safe.…”

Efficacy and safety of topical glycopyrrolate in patients with facial hyperhidrosis: a randomized, multicentre, double‐blinded, placebo‐controlled, split‐face study

“…9,10 Topical agents including aluminium chloride, formaldehyde, glutaraldehyde and potassium permanganate have been used but only have a short-term effect. [11][12][13][14] In addition, oral anticholinergics have been tried, but adverse effects such as blurred vision and urinary retention limited their efficiency. 15 Other treatments such as the surgical excision of affected areas, for example, the eccrine glands of the forehead, have been useful in appropriate cases.…”

“…The treatment of facial hyperhidrosis remains difficult, and treatment methods can be divided into those which affect the sweat glands directly and those which modify their innervations . Topical agents including aluminium chloride, formaldehyde, glutaraldehyde and potassium permanganate have been used but only have a short‐term effect . In addition, oral anticholinergics have been tried, but adverse effects such as blurred vision and urinary retention limited their efficiency .…”

The use of topical glycopyrrolate in the treatment of hyperhidrosis

“…1,2 Thus topical agents including aluminium chloride, formaldehyde, glutaraldehyde and potassium permanganate have been used but all produce only a short-term effect. [3][4][5][6] In addition, oral anticholinergics have been tried but adverse effects such as blurred vision and urinary retention limit their efficiency, although iontophoresis has led to some success with tapwater 1 and topical anticholinergics. 7 Next, the surgical excision of affected areas, for example the eccrine glands of the axilla, has been useful in appropriate cases, 8 while more recently, endoscopic sympathectomy has been used, but this can result in significant adverse effects such as compensatory hyperhidrosis, cardiac sympathetic denervation and Horner's syndrome.…”