Effect of timing of collection of salivary metabolomic biomarkers on oral cancer detection

Ishikawa, Shinya; Sugimoto, Masahiro; Kitabatake, Kenichiro; Tu, Manghui; Sugano, Akira; Yamamori, Iku; Iba, Asuka; Yusa, Kosuke; Kaneko, Miku; Ota, Sana; Hiwatari, Kana; Enomoto, Ayame; Tomita, Masaru; Iino, Mitsuyoshi

doi:10.1007/s00726-017-2378-5

Cited by 63 publications

(52 citation statements)

References 21 publications

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“…Saliva represents another non‐invasive biological fluid and biomarker discovery was performed for oral and pancreatic cancer. Metabolomic profiling of cerebrospinal fluid (CSF) was performed to identify biomarkers for Alzheimer's disease .…”

Section: Analytical Applicationsmentioning

confidence: 99%

Recent advances in capillary electrophoresis‐mass spectrometry: Instrumentation, methodology and applications

et al. 2018

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Capillary electrophoresis (CE) offers fast and high‐resolution separation of charged analytes from small injection volumes. Coupled to mass spectrometry (MS), it represents a powerful analytical technique providing (exact) mass information and enables molecular characterization based on fragmentation. Although hyphenation of CE and MS is not straightforward, much emphasis has been placed on enabling efficient ionization and user‐friendly coupling. Though several interfaces are now commercially available, research on more efficient and robust interfacing with nano‐electrospray ionization (ESI), matrix‐assisted laser desorption/ionization (MALDI) and inductively coupled plasma mass spectrometry (ICP) continues with considerable results. At the same time, CE‐MS has been used in many fields, predominantly for the analysis of proteins, peptides and metabolites. This review belongs to a series of regularly published articles, summarizing 248 articles covering the time between June 2016 and May 2018. Latest developments on hyphenation of CE with MS as well as instrumental developments such as two‐dimensional separation systems with MS detection are mentioned. Furthermore, applications of various CE‐modes including capillary zone electrophoresis (CZE), nonaqueous capillary electrophoresis (NACE), capillary gel electrophoresis (CGE) and capillary isoelectric focusing (CIEF) coupled to MS in biological, pharmaceutical and environmental research are summarized.

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Section: Analytical Applicationsmentioning

confidence: 99%

Recent advances in capillary electrophoresis‐mass spectrometry: Instrumentation, methodology and applications

et al. 2018

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“…To detect oral cancer using metabolites, it is necessary to know how long saliva collects after a meal . Saliva from cancer patients was collected 1.5 and 3.5 hours after breakfast and 12 hours after dinner and was studied using CE‐MS.…”

Section: Metabolomics Biomedical Studiesmentioning

confidence: 99%

Recent advances in amino acid analysis by capillary electromigration methods: June 2015–May 2017

et al. 2017

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Recent advances in amino acid analysis by capillary electromigration methods: June 2015-May 2017In the tenth edition of this article focused on recent advances in amino acid analysis using capillary electrophoresis, we describe the most important research articles published on this topic during the period from June 2015 to May 2017. This article follows the format of the previous articles published in Electrophoresis. The new developments in amino acid analysis with CE mainly describe improvements in CE associated with mass spectrometry. Focusing on applications, we mostly describe clinical works, although metabolomics studies are also very important. Finally, works focusing on amino acids in food and agricultural applications are also described.

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“…It has been studied in various compartments within the human body, including the oral cavity, gut, and vagina. [5][6][7] These metabolites represent the downstream end product of multiple pathways acting in concert and can provide a framework in which to study human health and disease. An example of the clinical use of metabolomics can best be illustrated with gut metabolomics and cancer.…”

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confidence: 99%

Women with Symptomatic Preterm Birth Have a Distinct Cervicovaginal Metabolome

et al. 2017

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Objective The objective was to determine if women with symptoms of preterm labor who ultimately have a spontaneous preterm birth (sPTB) have a distinct cervicovaginal (CV) metabolome compared with women who deliver at term. Study Design A nested case–control study of women presenting with symptoms of preterm labor was performed. CV fluid was collected from women between 22 and 336/7 weeks' gestation. The CV metabolome was compared between women with sPTB (n = 20) and women who delivered at term (n = 30). Global biochemical profiles were determined using ultraperformance liquid chromatography/tandem mass spectrometry. Welch's two-sample t-test was used to identify metabolites that differed significantly. Level of significance was defined as p ≤ 0.05. Results Eighty-eight percent of women were African-American and none had a prior history of sPTB. A total of 301 metabolites were identified in CV fluid. Thirty metabolites were significantly different in women with preterm birth compared with term birth. Two metabolites (mannitol and methyl phosphate) were significantly upregulated, and the remaining 28 metabolites were significantly downregulated and consisted of medium chain-fatty acids and collagen degradation markers. Conclusion The CV metabolome is significantly altered among women who present with preterm labor symptoms and ultimately have a sPTB.

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Effect of timing of collection of salivary metabolomic biomarkers on oral cancer detection

Cited by 63 publications

References 21 publications

Recent advances in capillary electrophoresis‐mass spectrometry: Instrumentation, methodology and applications

Recent advances in capillary electrophoresis‐mass spectrometry: Instrumentation, methodology and applications

Recent advances in amino acid analysis by capillary electromigration methods: June 2015–May 2017

Women with Symptomatic Preterm Birth Have a Distinct Cervicovaginal Metabolome

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