“Effect of time-restricted feeding on high-fat diet-induced metabolic dysfunction in Drosophila melanogaster”

Salgado-Canales, Daniela; Quenti, Daniela; Lourido, Fernanda; Cifuentes, Mariana; Tobar, Nicolás

doi:10.1016/j.bbadis.2023.166749

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…The genetic variation of fasting‐induced starvation resistance that we observe here highlights the importance of exploring the natural variation present within a trait when seeking to understand responses to potential treatments. Over the last 20 years, 16 publications have focused their study on periodic fasting, intermittent fasting or time‐restricted feeding in Drosophila (Aggarwal, 2014; Catterson et al, 2018; Dissel et al, 2022; Gill et al, 2015; Liu et al, 2021; Livelo et al, 2023; Melkani et al, 2017; Oishi et al, 2004; Ratliff et al, 2016; Salgado‐Canales et al, 2023; Ulgherait et al, 2021; Villanueva et al, 2019; Xu et al, 2011; Zhang et al, 2018; Zhang et al, 2023). Only two of these considered a panel of genetic backgrounds (Aggarwal, 2014; Ulgherait et al, 2021), and only one used fly lines maintained in labs for less than 50 years (Aggarwal, 2014).…”

Section: Discussionmentioning

confidence: 99%

Improvement of starvation resistance via periodic fasting is genetically variable in Drosophila melanogaster

Lenhart,

Ahsan,

McHaty

et al. 2024

Physiological Entomology

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Organisms subjected to periodic nutrient limitation early in life exhibit improvements in aspects of survival, including resistance to some environmental stressors. Recent findings indicate that forms of periodic fasting, such as intermittent fasting and time‐restricted feeding, can improve starvation resistance. However, it remains unclear to what extent this survival improvement persists across different genetic backgrounds. In this study, we examine fasting‐induced starvation resistance across a broad survey of wild‐derived lineages and document genetic variation within this trait. We adopt a standard dietary intervention and show improvement in starvation resistance within a common laboratory lineage, replicating previous results. Next, we examine fasting‐induced starvation resistance across isofemale lines collected across latitudes and in different seasons, and among inbred lines derived from flies collected on different continents. We discover genetic variation of fasting‐induced starvation resistance and show that fasting improved starvation resistance as often as it worsened starvation resistance. Fasted flies generally showed reduced fat concentration, and their starvation survival varied with sex, season of collection and geographic origin. While specific lineages common to the laboratory can show a specific fasting‐induced phenotype, we show that this result is not consistent across genetic backgrounds, reinforcing the idea that phenotypes observed in historic laboratory strains may not be conserved across a species.

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Section: Discussionmentioning

confidence: 99%

Improvement of starvation resistance via periodic fasting is genetically variable in Drosophila melanogaster

Lenhart,

Ahsan,

McHaty

et al. 2024

Physiological Entomology

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Periodic protein‐restricted diets extend the lifespan of high‐fat diet‐induced Drosophila melanogaster males

Wang,

Zhu,

Huang

et al. 2024

Aging Cell

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Research has shown that sustained protein restriction can improve the effects of a high‐fat diet on health and extend lifespan. However, long‐term adherence to a protein‐restricted diet is challenging. Therefore, we used a fly model to investigate whether periodic protein restriction (PPR) could also mitigate the potential adverse effects of a high‐fat diet and extend healthy lifespan. Our study results showed that PPR reduced body weight, lipid levels, and oxidative stress induced by a high‐fat diet in flies and significantly extended the healthy lifespan of male flies. Lipid metabolism and transcriptome results revealed that the common differences between the PPR group and the control group and high‐fat group showed a significant decrease in palmitic acid in the PPR group; the enriched common differential pathways Toll and Imd were significantly inhibited in the PPR group. Further analysis indicated a significant positive correlation between palmitic acid levels and gene expression in the Toll and Imd pathways. This suggests that PPR effectively improves fruit fly lipid metabolism, reduces palmitic acid levels, and thereby suppresses the Toll and Imd pathways to extend the healthy lifespan of flies. Our study provides a theoretical basis for the long‐term effects of PPR on health and offers a new dietary adjustment option for maintaining health in the long term.

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“Effect of time-restricted feeding on high-fat diet-induced metabolic dysfunction in Drosophila melanogaster”

Cited by 2 publications

References 30 publications

Improvement of starvation resistance via periodic fasting is genetically variable in Drosophila melanogaster

Improvement of starvation resistance via periodic fasting is genetically variable in Drosophila melanogaster

Periodic protein‐restricted diets extend the lifespan of high‐fat diet‐induced Drosophila melanogaster males

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