Effect of the skincare product on facial skin microbial structure and biophysical parameters: A pilot study

Hwang, Bo Kyoung; Lee, Sado; Myoung, Joonoh; Hwang, Seung Jin; Lim, Jun Man; Jeong, Eui Taek; Park, Sun Gyoo; Youn, Sung Hun

doi:10.1002/mbo3.1236

Cited by 10 publications

(13 citation statements)

References 61 publications

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“…65 Skin dryness can lead to irritation while elevated pH contributes to skin disease and use of appropriate skin care products may restore and preserve skin health. 55 Cleansers with pH close to normal physiologic levels (approximately 5) are a good choice for acne skin to minimize impact on the skin barrier and to favour microbial balance. Conversely, 'poor choices made by an uninformed patient may derail an otherwise ideal therapeutic approach'.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the authors suggest use that skincare regimen can 'affect the microbial structure of facial skin as well as the biophysical properties'. 55 Cardiello et al and Kong et al also reported that use of skin care products could increase microbial diversity. 56,57 Thermal water is interesting because its physicochemical characteristics may include soluble minerals and trace elements such as selenium or strontium.…”

Section: Maintenance and Protection Of Microbiome: Cleansers And Mois...mentioning

confidence: 98%

“…53 Similarly, a separate dermocosmetic based on thermal water showed a marked antibiofilm activity on both C. acnes and S. aureus. 54 In 2021, Hwang et al 55 reported that daily use of a moisturizer for 4 weeks (n = 25 women) increased bacterial diversity, considered a marker of healthy skin.…”

Section: Maintenance and Protection Of Microbiome: Cleansers And Mois...mentioning

confidence: 99%

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Acne microbiome: From phyla to phylotypes

Dreno,

Dekio,

Baldwin

et al. 2023

Acad Dermatol Venereol

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Acne vulgaris is a chronic inflammatory skin disease with a complex pathogenesis. Traditionally, the primary pathophysiologic factors in acne have been thought to be: (1) altered sebum production, (2) inflammation, (3) excess keratinization and (4) colonization with the commensal Cutibacterium acnes. However, the role of C. acnes has been unclear, since virtually all adults have C. acnes on their skin yet not all develop acne. In recent years, understanding of the role of C. acnes has expanded. It is still acknowledged to have an important place in acne pathogenesis, but evidence suggests that an imbalance of individual C. acnes phylotypes and an alteration of the skin microbiome trigger acne. In addition, it is now believed that Staphylococcus epidermidis is also an actor in acne development. Together, C. acnes and S. epidermidis maintain and regulate homeostasis of the skin microbiota. Antibiotics, which have long been a staple of acne therapy, induce cutaneous dysbiosis. This finding, together with the long‐standing public health edict to spare antibiotic use when possible, highlights the need for a change in acne management strategies. One fertile direction of study for new approaches involves dermocosmetic products that can support epidermal barrier function and have a positive effect on the skin microbiome.

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Section: Discussionmentioning

confidence: 99%

Section: Maintenance and Protection Of Microbiome: Cleansers And Mois...mentioning

confidence: 98%

Section: Maintenance and Protection Of Microbiome: Cleansers And Mois...mentioning

confidence: 99%

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Acne microbiome: From phyla to phylotypes

Dreno,

Dekio,

Baldwin

et al. 2023

Acad Dermatol Venereol

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“…Kotakeyama et al [7] reported that the skin microbiome of healthy females correlated with the number of pores and the amount of sebum produced. Hwang et al [8] showed that skin hydration and texture correlated with bacterial diversity and changes in the microbial community on facial skin. Furthermore, bacterial diversity was greater in subjects with low hydration than in those with high hydration, and the relative abundance of Cutibacterium spp.…”

Section: Introductionmentioning

confidence: 99%

Relationship between skin fungal and bacterial microbiomes and skin pH

Akaza¹,

Takasaki²,

Matsudaira³

et al. 2023

Intern J of Cosmetic Sci

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Objective: The present study investigated the relationship between the skin bacterial and fungal microbiomes and skin pH at sebaceous sites, namely, the forehead, cheek and upper chest. We also examined the relationship between the skin microbiome and transepidermal water loss (TEWL), which is an indicator of rough skin.Methods: Thirty healthy Japanese subjects (15 females and 15 males) were enrolled as subjects. The forehead, cheek and upper chest were examined in August (summer) and February (winter). Skin surface samples were collected using the swab method, and the 16s rRNA and ITS regions were analysed using nextgeneration sequencing. Skin pH and TEWL were also assessed. Results:The changes observed in the skin microbiome were associated with season-dependent changes in skin pH. An increase in skin pH at the forehead and cheek was associated with a higher relative abundance of Cutibacterium spp., a reduction in bacterial diversity, and a lower relative abundance of Staphylococcus spp. A decrease in skin pH at the upper chest was associated with a higher relative abundance of Malassezia restricta, a lower relative abundance of M. sympodialis and decrease in fungal diversity. Moreover, these changes were also associated with an increase in TEWL. Conclusion:The present results indicate that changes in skin pH are associated with changes in the skin bacterial and fungal microbiomes at sebaceous sites. The changes observed in the skin microbiome were also associated with rough skin.

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“…Due to the important role, that a balanced skin microbiome may play in maintaining optimal skin health, appropriate skin care that limits the overgrowth of pathogenic microbial species while reducing oxidative stress and restoring skin homeostasis appears to be crucial in the prevention and therapy of dermatologic conditions [3,14]. Not surprisingly, there is an increasing research interest into natural sources of bio-actives with implicated anti-oxidative and protective properties that act synergistically with other active ingredients of the cosmetic formulation and can strengthen skin barrier integrity and its immune defense system.…”

Section: Introductionmentioning

confidence: 99%

Skin Beautification with an ImmunatuRNA® Complex: A Natural Complex Based on Yeast RNA and Marine Derivatives on the Human Skin Immunity and Microbiome Composition

Neymann¹

2023

J Immuno Allerg

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The skin is the largest organ of human body implicated in vital physiological and immunological processes, including protection against injury, infections, and environmental exposures. Nevertheless, a number of negative external and internal factors, including increased pollution along with modern lifestyle can significantly influence on the skin immunity, promote aging and reduce regenerative capabilities. Cosmetic formulations based on natural ingredients, including plant and marine/algae extracts, and microbial-derived bio-actives may help to maintain healthy skin condition and protect its beautiful appearance. The ImmunatuRNA®* (*The trademark ImmunatuRNA® is a registered trademark in the European Union EUTM 018365297 and Great Britain UK00003630172. Any reference to the registration of the ImmunatuRNA® trademark applies to the designated territories), a signature complex (VRFD SA/VERDILAB Switzerland) based on the Natural RNA molecules obtained from yeasts, with added marine exopolysaccharides and natural hyaluronic acid with potential benefits for antibacterial and antiradical defense and maintaining skin detox homeostasis. Therefore, the main aim of this study is to experimentally assess the ImmunatuRNA® complex capabilities to enhance natural skin antioxidant defenses and protection against oxidative stress, by using human fibroblast cell culture. Additionally, this study will investigate the effects of the skincare products with added ImmunatuRNA® complex on the skin microbiome composition in the group of healthy adults with various skin types. The results obtained from the in vitro studies consistently demonstrated that treatment with an ImmunatuRNA® complex protects human fibroblasts against exposure to pro-oxidants, while at the same time enhances anti-oxidative defenses of these cells, demonstrated as reduced formation of free radicals and upregulation of SIRT-1 protein. Furthermore, the cosmetic intervention carried on the group of 10 healthy human volunteers with different skin types (oily, dry, combined, normal) aged between 23 and 65 years old demonstrated that using interchangeably of two cosmetic products-a Natural Moisturizer Probiotic Cream and Natural Detox Replenishing Face Mask containing the ImmunatuRNA® complex, for 4-weeks led to favorable changes in the composition of skin microbiome observed as a reduction of relative abundance of adverse microorganisms, previously linked to the skin inflammation and infections, such as Citrobacter koseri, Bacillus spp., Enterococcus spp., Alcaligenes spp., Pantoea spp. and Staphylococcus aureus. Based on following results, the use of skincare products containing the ImmunatuRNA® complex can help maintain a healthy skin microbiome while possibly preventing against infections and negative environmental exposures, in particularly against oxidative stress in healthy adults with all types of skin with age range 23-65 years old.

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Effect of the skincare product on facial skin microbial structure and biophysical parameters: A pilot study

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 10 publications

References 61 publications

Acne microbiome: From phyla to phylotypes

Acne microbiome: From phyla to phylotypes

Relationship between skin fungal and bacterial microbiomes and skin pH

Skin Beautification with an ImmunatuRNA® Complex: A Natural Complex Based on Yeast RNA and Marine Derivatives on the Human Skin Immunity and Microbiome Composition

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