Effect of the proportion of curcuminoids on the gastroprotective action of Curcuma longa L. in rats

Abstract

The gastroprotective effect of a turmeric acetone extract (TAE) (Curcuma longa L.[Zingiberaceae]) was evaluated and compared to that of its major curcuminoids; curcumin (CUR), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC). Additionally, to demonstrate the importance of the metabolites' ratio in the extract on the synergistic effect, different mixtures were evaluated. An ethanol-induced gastric injury model was used to evaluate the gastroprotection in Wistar rats. The pharmacologic interaction analysis was performed using the Combination Index (CI)-Isobologram Equation method. The CI calculated at 0.5 of affected fraction (fa) for the TAE indicated a synergistic interaction between its components. However, when the proportion of curcuminoids changed to a 1:1:1 ratio, the CI implied an antagonistic effect. The binary combinations of curcuminoids (1:1) also showed an antagonistic interaction.The results of this work suggest that the proportion of curcuminoids in the TAE are crucial for the gastroprotective effect against ethanol-induced damage.

The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis

“…Compared with curcumin monomer, because Curcuma longa extract contains more components, it may play a multitarget and multisignal pathway transduction role in the treatment of OA pain and inflammation in the molecular pathology mechanism [ 56 , 57 ]. Meanwhile, Curcuma longa is a multicomponent botanical drug, and the synergy between its components may bring potential clinical effects in the treatment of OA [ 58 , 59 ]. These components may increase the concentration of each other in the blood of patients with OA through pharmacokinetics and increase the time of each other’s stay in the body, thereby exerting a better clinical effect.…”

The ameliorative effect of turmeric (Curcuma longa Linn) extract and its major constituent, curcumin, and its analogs on ethanol toxicity

“…Their results disclosed that the gastroprotective activity of turmeric acetone extract surpasses that of curcuminoids when used alone. The efficacy of turmeric acetone extract in preventing ulcers in an ethanol‐induced injury rat model is contingent upon the proportion of curcuminoids present, as altering the ratio from 3.7:1:10 to 1:1:1 affects its activity (Orona‐Ortiz et al, 2021). These findings underscore the significance of curcuminoid proportion in augmenting turmeric gastroprotection activity.…”

Bisdemethoxycurcumin Induces Cell Apoptosis and Inhibits Human Brain Glioblastoma GBM 8401/Luc2 Cell Xenograft Tumor in Subcutaneous Nude Mice In Vivo

“…Curcuminoids contain three major bioactive ingredients: curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC), at a ratio of 77:17:3 [ 13 ]. The curcuminoids in the turmeric acetone extract are crucial for the gastroprotective effect against ethanol-induced damage [ 14 ]. BDMC prevented kidney fibrosis by activating fibroblast apoptosis [ 15 ] and promoted apoptosis in human platelets via activation of ERK signaling pathway [ 16 ].…”