2015
DOI: 10.1111/jre.12274
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Abstract: Local use of the probiotic did not result in any adverse effects on periodontal tissues. When used as monotherapy or as an adjuvant, the probiotic was effective at controlling periodontitis in rats.

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Cited by 53 publications
(68 citation statements)
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“…Probiotics administered systemically via drinking water in a ligatureinduced PD model resulted in reduced alveolar bone loss and protected the intestine from reactive changes (Garcia et al, 2016;Messora et al, 2013Messora et al, , 2016. Recently, probiotic therapy has been reported to decrease the number of TRAP-positive cells for the probiotic-treated groups when compared with controls in periodontal tissues surrounding teeth submitted to mechanical loading (Pazzini et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Probiotics administered systemically via drinking water in a ligatureinduced PD model resulted in reduced alveolar bone loss and protected the intestine from reactive changes (Garcia et al, 2016;Messora et al, 2013Messora et al, , 2016. Recently, probiotic therapy has been reported to decrease the number of TRAP-positive cells for the probiotic-treated groups when compared with controls in periodontal tissues surrounding teeth submitted to mechanical loading (Pazzini et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…Mice treated with locally administered probiotics have been shown to have significantly decreased bone loss and lower expression of inflammatory cytokines (Maekawa & Hajishengallis, ). Probiotics administered systemically via drinking water in a ligature‐induced PD model resulted in reduced alveolar bone loss and protected the intestine from reactive changes (Garcia et al., ; Messora et al., , ). Recently, probiotic therapy has been reported to decrease the number of TRAP‐positive cells for the probiotic‐treated groups when compared with controls in periodontal tissues surrounding teeth submitted to mechanical loading (Pazzini et al., ).…”
Section: Discussionmentioning
confidence: 99%
“…Using this model, mice with periodontitis that were treated with Lactobacillus brevis CD2 displayed decreased bone loss and lower expression of pro-inflammatory cytokines such as tumor necrosis factor, interleukin-1β and -17A (Fig 5). Similar studies in a rat model of periodontal disease indicate that probiotics (Bacillus subtilus and Saccharomyces cerevisiae ) can decrease bone resorption, increased bone density, and decreased inflammation [99, 100]; dysbiosis was also prevented by probiotic treatment [99]. …”
Section: ) Mechanisms Of Probiotic Prevention Of Bone Pathophysiologymentioning
confidence: 99%
“…The supply of the probiotic bacterium L. reuteri in mice predisposed to type 1 diabetes results in a reversal of type 1 diabetes‐mediated bone loss . Supplying Saccharomyces cerevisiae in rats results in a decrease in the concentration of tumor necrosis factor (TNF) and interleukin‐1 β (IL‐1 β ) and an increase in the concentration of the anti‐inflammatory cytokine interleukin‐10 (IL‐10), which decreases calcium loss from tooth tissue and positively affects the hard teeth repair process …”
Section: Animal Studiesmentioning
confidence: 99%