Effect of the plant compound indole-3-carbinol on hepatic cholesterol homoeostasis

Effects of indole-3-carbinol on metabolic parameters and on lipogenesis and lipolysis in adipocytes 182

“…This dose had no effect on food consumption, rat weight, or general appearance and behaviour and was comparable to those used by other researchers (Bradlow et al, 1991;LeBlanc et al, 1994;Stresser et al, 1995).…”

“…According to LeBlanc et al (1994) the hepatic microsomal total cholesterol levels were not significantly altered following the treatment with 100 and 240 mg I3C/kg/day for 1 week in mice. It means that the pivotal activity of hepatic cholesterol 7α-hydroxylase, which enhances cholesterol conversion to bile acids, and hepatic enzymes cholesterol ester hydrolase were not altered by I3C.…”

Effects of indole-3-carbinol on metabolic parameters and on lipogenesis and lipolysis in adipocytes 182

“…This dose had no effect on food consumption, rat weight, or general appearance and behaviour and was comparable to those used by other researchers (Bradlow et al, 1991;LeBlanc et al, 1994;Stresser et al, 1995).…”

“…According to LeBlanc et al (1994) the hepatic microsomal total cholesterol levels were not significantly altered following the treatment with 100 and 240 mg I3C/kg/day for 1 week in mice. It means that the pivotal activity of hepatic cholesterol 7α-hydroxylase, which enhances cholesterol conversion to bile acids, and hepatic enzymes cholesterol ester hydrolase were not altered by I3C.…”

Broccoli (Brassica oleracea var.italica) Sprouts and Extracts Rich in Glucosinolates and Isothiocyanates Affect Cholesterol Metabolism and Genes Involved in Lipid Homeostasis in Hamsters

“…This lack of correlation between hepatic and plasma cholesterol levels could be due to a difference in cholesterol excretion through the bile that was not considered in this experiment. However, some compounds such as indole-3-carbinol fed to male CD-1 mice at 500 and 750 mg/kg/day lowered hepatic cholesterol levels without affecting serum cholesterol, 28 indicating a similar regulatory mechanism for BSX10 and SFE treatment.…”

NTP Technical Report on the Toxicology Studies of Indole-3-carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Indole-3-carbinol in Harlan Sprague Dawley Rats and B6C3F1/N Mice (Gavage Studies)

“…In male guinea pigs, indole-3-carbinol exposure induced steatosis in the liver, primarily in periportal hepatocytes 17 . In male CD-1 mice exposed to 500 or 750 mg/kg per day in the feed for 5 days, indole-3-carbinol significantly increased liver weight and microsomal protein content 18 . This study also showed that indole-3-carbinol alters cholesterol homeostasis.…”

Effects of indole-3-carbinol on metabolic parameters and on lipogenesis and lipolysis in adipocytes 182

“…This dose had no effect on food consumption, rat weight, or general appearance and behaviour and was comparable to those used by other researchers (Bradlow et al, 1991;LeBlanc et al, 1994;Stresser et al, 1995).…”

“…According to LeBlanc et al (1994) the hepatic microsomal total cholesterol levels were not significantly altered following the treatment with 100 and 240 mg I3C/kg/day for 1 week in mice. It means that the pivotal activity of hepatic cholesterol 7α-hydroxylase, which enhances cholesterol conversion to bile acids, and hepatic enzymes cholesterol ester hydrolase were not altered by I3C.…”

Broccoli (Brassica oleracea var.italica) Sprouts and Extracts Rich in Glucosinolates and Isothiocyanates Affect Cholesterol Metabolism and Genes Involved in Lipid Homeostasis in Hamsters

“…This lack of correlation between hepatic and plasma cholesterol levels could be due to a difference in cholesterol excretion through the bile that was not considered in this experiment. However, some compounds such as indole-3-carbinol fed to male CD-1 mice at 500 and 750 mg/kg/day lowered hepatic cholesterol levels without affecting serum cholesterol, 28 indicating a similar regulatory mechanism for BSX10 and SFE treatment.…”

NTP Technical Report on the Toxicology Studies of Indole-3-carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Indole-3-carbinol in Harlan Sprague Dawley Rats and B6C3F1/N Mice (Gavage Studies)

“…In male guinea pigs, indole-3-carbinol exposure induced steatosis in the liver, primarily in periportal hepatocytes 17 . In male CD-1 mice exposed to 500 or 750 mg/kg per day in the feed for 5 days, indole-3-carbinol significantly increased liver weight and microsomal protein content 18 . This study also showed that indole-3-carbinol alters cholesterol homeostasis.…”

Effects of indole-3-carbinol on metabolic parameters and on lipogenesis and lipolysis in adipocytes 182

“…This dose had no effect on food consumption, rat weight, or general appearance and behaviour and was comparable to those used by other researchers (Bradlow et al, 1991;LeBlanc et al, 1994;Stresser et al, 1995).…”

“…According to LeBlanc et al (1994) the hepatic microsomal total cholesterol levels were not significantly altered following the treatment with 100 and 240 mg I3C/kg/day for 1 week in mice. It means that the pivotal activity of hepatic cholesterol 7α-hydroxylase, which enhances cholesterol conversion to bile acids, and hepatic enzymes cholesterol ester hydrolase were not altered by I3C.…”

Broccoli (Brassica oleracea var.italica) Sprouts and Extracts Rich in Glucosinolates and Isothiocyanates Affect Cholesterol Metabolism and Genes Involved in Lipid Homeostasis in Hamsters

“…This lack of correlation between hepatic and plasma cholesterol levels could be due to a difference in cholesterol excretion through the bile that was not considered in this experiment. However, some compounds such as indole-3-carbinol fed to male CD-1 mice at 500 and 750 mg/kg/day lowered hepatic cholesterol levels without affecting serum cholesterol, 28 indicating a similar regulatory mechanism for BSX10 and SFE treatment.…”

NTP Technical Report on the Toxicology Studies of Indole-3-carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Indole-3-carbinol in Harlan Sprague Dawley Rats and B6C3F1/N Mice (Gavage Studies)

“…In male guinea pigs, indole-3-carbinol exposure induced steatosis in the liver, primarily in periportal hepatocytes 17 . In male CD-1 mice exposed to 500 or 750 mg/kg per day in the feed for 5 days, indole-3-carbinol significantly increased liver weight and microsomal protein content 18 . This study also showed that indole-3-carbinol alters cholesterol homeostasis.…”