2016
DOI: 10.18632/aging.101143 View full text |Buy / Rent full text
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Abstract: Iodide is a micronutrient essential for thyroid hormone production. The uptake and metabolism of iodide by thyrocytes is crucial to proper thyroid function. Iodide ions are drawn into the thyroid follicular cell via the sodium-iodide symporter (NIS) in the cell membrane and become integrated into tyrosyl residues to ultimately form thyroid hormones. We sought to learn how an abnormal concentration of iodide within thyrocyte can have significant effects on the thyroid, specifically the surrounding vascular netw… Show more

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“…An investigation of thyroid carcinoma angiogenesis by Daniell et al . indicated that regulation of the HIF-1 and VEGF-dependent pathway modulates angiogenesis 38 . Furthermore, Yin et al .…”
Section: Discussionmentioning
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“…An investigation of thyroid carcinoma angiogenesis by Daniell et al . indicated that regulation of the HIF-1 and VEGF-dependent pathway modulates angiogenesis 38 . Furthermore, Yin et al .…”
Section: Discussionmentioning
“…Although the VEGF/VEGFR signaling pathway has been shown to be essential for vessel formation in the tibial growth plate under hypoxia, the underlying mechanisms of the specific role of this pathway in tibial chondrocyte proliferation and development are unclear 9 , 38 , 39 . Next, thiram-induced TD in AACs was evaluated, and we found that thiram could inhibit the development of the tibia and increase tibial growth plate width susceptibility to fractures, as shown in Fig.…”
Section: Discussionmentioning
“…Thus the vasculature also influences the response of tumor cells to drugs. The compactness of a solid tumor increases blood flow resistance and this causes gradients of nutrients and oxygen, meaning that there are different proliferation rates in different regions of the tumor [ 126 , 127 , 128 , 129 , 130 , 131 ]. Nutrient deprivation is also a result of blood flow resistance.…”
Section: Tumor Microenvironmentmentioning
“…Furthermore, thyroid hormone (T4), a hormone secreted by the thyroid, has the ability to promote general tissue metabolism and improve nerve excitability and physical development related to angiogenesis . The membrane receptor integrin αvβ3 could mediate the activity of T4, and then activated T4 can regulate the fibroblast growth factor 2 (FGF2), a downstream factor of HDAC5, and enhance the expression of FGF2 mRNA via αvβ3‐PKD‐HDAC5 signaling pathway, and then contribute to the T4‐indured angiogenesis …”
Section: Hdac5 and Angiogenesismentioning