Effect of the flavonoid quercetin on cadmium-induced hepatotoxicity

Vicente-Sánchez, C.; Egido, Jaime; Sánchez-González, Penélope; Pérez‐Barriocanal, Fernando; López‐Novoa, José M.; Morales, Ana Isabel

doi:10.1016/j.fct.2008.03.009

Cited by 95 publications

(66 citation statements)

References 40 publications

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“…These results are consistent with our previous acute Cd toxicity study (17). AST and ALT are specific markers of Cd-induced hepatic damage (24,25), and NAG is considered to be the best urine marker of Cd-induced renal damage (26,27). The restoration of these biological parameters in the mice that were given CCFM8610 orally further confirms the protective effects of this strain against chronic Cd toxicity.…”

Section: Discussionsupporting

confidence: 91%

“…As no obvious difference between the tissue Cd levels of these two groups was found, the higher MT level in the Cd-plus-CCFM8610 IP group should be a reflection of MT induction by CCFM8610, which provides further evidence of the direct anti-oxidative-stress property of CCFM8610. Supporting our findings, rodent treatment with a flavonoid (24) or Ganoderma lucidum spores (40) has been used to increase the MT level in tissues, which in turn offers protection against Cd-induced oxidative stress.…”

Section: Discussionsupporting

confidence: 80%

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Protective Effects of Lactobacillus plantarum CCFM8610 against Chronic Cadmium Toxicity in Mice Indicate Routes of Protection besides Intestinal Sequestration

Zhai

Wang

Zhao

et al. 2014

Appl Environ Microbiol

115

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cOur previous study confirmed the ability of Lactobacillus plantarum CCFM8610 to protect against acute cadmium (Cd) toxicity in mice. This study was designed to evaluate the protective effects of CCFM8610 against chronic Cd toxicity in mice and to gain insights into the protection mode of this strain. Experimental mice were divided into two groups and exposed to Cd for 8 weeks via drinking water or intraperitoneal injection. Both groups were further divided into four subgroups, control, Cd only, CCFM8610 only, and Cd plus CCFM8610. Levels of Cd were measured in the feces, liver, and kidneys, and alterations of several biomarkers of Cd toxicity were noted. The results showed that when Cd was introduced orally, cotreatment with Cd and CCFM8610 effectively decreased intestinal Cd absorption, reduced Cd accumulation in tissue, alleviated tissue oxidative stress, reversed hepatic and renal damage, and ameliorated the corresponding histopathological changes. When Cd was introduced intraperitoneally, administration of CCFM8610 did not have an impact on tissue Cd accumulation or reverse the activities of antioxidant enzymes. However, CCFM8610 still offered protection against oxidative stress and reversed the alterations of Cd toxicity biomarkers and tissue histopathology. These results suggest that CCFM8610 is effective against chronic cadmium toxicity in mice. Besides intestinal Cd sequestration, CCFM8610 treatment offers direct protection against Cd-induced oxidative stress. We also provide evidence that the latter is unlikely to be mediated via protection against Cd-induced alteration of antioxidant enzyme activities.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 80%

Protective Effects of Lactobacillus plantarum CCFM8610 against Chronic Cadmium Toxicity in Mice Indicate Routes of Protection besides Intestinal Sequestration

Zhai

Wang

Zhao

et al. 2014

Appl Environ Microbiol

115

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“…Our study revealed that quercetin significantly increased NO levels in both serum and liver tissues of HCD-fed rats. Quercetin administration was proved to induce the eNOS expression, increasing the NO level that is important to maintain hepatocyte proliferation (Vicente-Sánchez et al, 2008;Inukai et al, 2010). Furthermore, Romero et al (2010) observed that quercetin enhanced the formation of NO through inhibition of eNOS phosphorylation.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of dietary flavonoid quercetin against lipemic-oxidative hepatic injury in hypercholesterolemic rats

Mariee

Abd‐Allah

El-Beshbishy³

2012

Pharmaceutical Biology

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“…Recently, some phytochemicals and plant extracts with antioxidative properties have been found to have the capacity to decrease tissue cadmium levels and cadmium-induced oxidative stress (15)(16)(17)(18). Such natural compounds have few side effects, and some of them can be served as dietary nutritional ingredients.…”

mentioning

confidence: 99%

Protective Effects of Lactobacillus plantarum CCFM8610 against Acute Cadmium Toxicity in Mice

Zhai

Wang

Zhao

et al. 2013

Appl Environ Microbiol

173

113

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bThis study evaluated the protective effects of Lactobacillus plantarum CCFM8610, a selected probiotic with good cadmium binding capacity, against acute cadmium toxicity in mice. Ninety mice were divided into prevention and therapy groups. In the prevention groups, CCFM8610 was administered at 10 9 CFU once daily for 7 days, followed by a single oral dose of cadmium chloride at 1.8 mg cadmium for each mouse. In the therapy groups, the same dose of CCFM8610 was administered for 2 days after an identical single dose of cadmium exposure. Mice that received neither cadmium nor culture or that received cadmium alone served as negative and positive controls, respectively. The effects of both living and dead CCFM8610 on cadmium ion concentrations in feces, liver, and kidney were determined. Moreover, the alterations in reduced glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and histopathology in the liver and kidney were investigated. The results showed that compared to the mice that received cadmium only, CCFM8610 treatment can effectively decrease intestinal cadmium absorption, reduce tissue cadmium accumulation, alleviate renal and hepatic oxidative stress, and ameliorate hepatic histopathological changes. Living CCFM8610 administered after cadmium exposure offered the most significant protection. Our results suggested that CCFM8610 is more effective against acute cadmium toxicity than a simple antioxidant treatment due to its special physiological functions and that it can be considered a new dietary therapeutic strategy against acute cadmium toxicity.

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Effect of the flavonoid quercetin on cadmium-induced hepatotoxicity

Cited by 95 publications

References 40 publications

Protective Effects of Lactobacillus plantarum CCFM8610 against Chronic Cadmium Toxicity in Mice Indicate Routes of Protection besides Intestinal Sequestration

Protective Effects of Lactobacillus plantarum CCFM8610 against Chronic Cadmium Toxicity in Mice Indicate Routes of Protection besides Intestinal Sequestration

Protective effect of dietary flavonoid quercetin against lipemic-oxidative hepatic injury in hypercholesterolemic rats

Protective Effects of Lactobacillus plantarum CCFM8610 against Acute Cadmium Toxicity in Mice

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