2013
DOI: 10.1111/jre.12138
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Abstract: aPDT, using low concentrations of MB and TBO, was the most effective adjuvant therapy to SRP, acting indirectly as a downregulator of the molecular mechanisms that control bone resorption in periodontitis.

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Cited by 74 publications
(105 citation statements)
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References 49 publications
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“…On the fifteenth day, the number of TRAP-positive cells was lowest than 3d and 7d for all treatment protocols. The G4 (28) showed significant differences when compared to G3 (38) and G5 (38). The difference between PD+ versus WPD were also significant.…”
Section: Resultsmentioning
confidence: 64%
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“…On the fifteenth day, the number of TRAP-positive cells was lowest than 3d and 7d for all treatment protocols. The G4 (28) showed significant differences when compared to G3 (38) and G5 (38). The difference between PD+ versus WPD were also significant.…”
Section: Resultsmentioning
confidence: 64%
“…The effect of aPDT (methylene blue 100 g /mL) on bone resorption were positive, when evidenced by TRAP detection [38]. The results revealed intense bone resorption at 7 days, and gradual RANKL and OPG proteins modulate the osteoclastogenesis.…”
Section: Discussionmentioning
confidence: 81%
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“…Um estudo em ratos comparou concentrações diferentes de metileno e toluidina (10mg/ml e 100µg/ml) e laser 660nm, sendo que as concentrações mais baixas dos dois corantes foram suficientes para promover menor perda óssea e diminuição de fatores indutores de osteoclasia (RANK) (GARCIA et al, 2014). Estudos in vitro mostraram que um dos mecanismos de ação dos corantes fenotiazínicos é gerar uma diminuição do ATP intracelular e aumento do ATP extracelular e a concentração do corante deve ser 2 a 4x maior para matar bactérias Gram negativas (ROMANOVA et al, 2003).…”
Section: Revisão De Literaturaunclassified