Effect of the addition of low rare earth elements (lanthanum, neodymium, cerium) on the biodegradation and biocompatibility of magnesium

Willbold, Elmar; Gu, Xuenan; Albert, Devon L.; Kalla, Katharina; Bobe, Katharina; Brauneis, Maria; Janning, Carla; Nellesen, J.; Czayka, Wolfgang; Tillmann, Wolfgang; Zheng, Yufeng; Witte, Frank

doi:10.1016/j.actbio.2014.09.041

Cited by 209 publications

(112 citation statements)

References 44 publications

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“…Feldhaus et al [110] reported on the activation of osteoblasts and positive effects to bone density in ovariectomized rats. Nonetheless, negative impacts on cell lines, organs and physiological processes were described for varying high concentrations of rare earth elements [111][112][113][114]. One possible reason might be the ionic radius which is similar to calcium [115], an essential element in metabolic processes.…”

Section: Discussionmentioning

confidence: 97%

In vivo evaluation of a magnesium-based degradable intramedullary nailing system in a sheep model

et al. 2015

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Section: Discussionmentioning

confidence: 97%

In vivo evaluation of a magnesium-based degradable intramedullary nailing system in a sheep model

et al. 2015

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“…Villanueva staining is a histological technique for undecalcified tissue and allows the observation of highly reactive Mg alloy interface without the occurrence of additional corrosion reactions caused by the staining agents itself. The examination of the distinguishable acellular bone matrix, which is nearly impossible through conventional histological method using optical microscopy (19), could be performed using Villanueva stain and fluorescence microscopy (SI Appendix, Fig. S3).…”

Section: Resultsmentioning

confidence: 99%

Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy

Lee

Han

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

367

236

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There has been a tremendous amount of research in the past decade to optimize the mechanical properties and degradation behavior of the biodegradable Mg alloy for orthopedic implant. Despite the feasibility of degrading implant, the lack of fundamental understanding about biocompatibility and underlying bone formation mechanism is currently limiting the use in clinical applications. Herein, we report the result of long-term clinical study and systematic investigation of bone formation mechanism of the biodegradable Mg-5wt%Ca-1wt%Zn alloy implant through simultaneous observation of changes in element composition and crystallinity within degrading interface at hierarchical levels. Controlled degradation of Mg-5wt%Ca-1wt%Zn alloy results in the formation of biomimicking calcification matrix at the degrading interface to initiate the bone formation process. This process facilitates early bone healing and allows the complete replacement of biodegradable Mg implant by the new bone within 1 y of implantation, as demonstrated in 53 cases of successful long-term clinical study.biodegradable implant | bone formation | clinical application T he century-old concept of the fixation device that holds the fractured bones in place to allow repair through the natural bone remodeling process is still being practiced today without alteration (1-5). The recent rapid growth of the elderly demographic of physically active adults has tremendously intensified the occurrence of bone trauma cases, highlighting once again the major drawbacks of current surgical approaches and osteosynthesis systems, such as inevitable secondary surgery to remove the inert fixation devices after complete bone healing and inflammatory response due to the release of metal ions. In the past decade, countless studies have been performed to control and optimize the mechanical and corrosion properties of magnesium-based alloys (6-9), which, thanks to their degradation in the physiological environment, could overcome the limitations of inert implant materials and shift the paradigm of conventional bone fixation devices toward new horizons. Driven by these new possibilities, important findings regarding, among others, the degradation mechanism of Mg-based alloys (10, 11), the formation of corrosion protective layers by degradation products (12, 13), and the osteogenetic properties of Mg ions (14, 15) have been reported in the literature. However, such findings are based on the observation of degradation products and of bone healing at the macroscale level. Due to lack of fundamental understanding on biocompatibility and underlying bone formation mechanism of the degradation product, there is so far only one known case of statistically insignificant clinical study result (16) with a short-term follow-up. In our previous study, we reported successful development and long-term in vivo study of uniformly slowly degrading Mg-5wt%Ca-1wt%Zn alloy system (SI Appendix, Figs. S1 and S2) featuring adequate mechanical strength [ultimate tensile strength (UTS) ∼250 MPa] (17) a...

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“…Currently magnesium alloys with rare earth elements possess favorable corrosion, mechanical properties, and biocompatibility. [154][155][156] The biocompatibility of Mg-rare earth alloys were investigated by Feyerabend et al [ 154 ] and Drynda et al [ 156 ] They found no negative in vitro effects on vascular smooth muscle cells (SMC), human osteosarcoma cells (MG63), human umblical cord perivascular (HUCPV) cells, and mouse macrophages (RAW 264.7) when the content of rare earth elements (e.g., La, Ce, Gd, Nd, Pr, Eu) was kept at low concentrations. According to these studies, Dy, Gd, Eu, Nd and Pr in particular are described as suitable alloying elements for magnesium.…”

Section: Biocompatibility Aspectsmentioning

confidence: 98%

Recent Advances in Biodegradable Metals for Medical Sutures: A Critical Review

Seitz

Ďurišin

Goldman

et al. 2015

Adv Healthcare Materials

209

158

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Sutures that biodegrade and dissolve over a period of several weeks are in great demand to stitch wounds and surgical incisions. These new materials are receiving increased acceptance across surgical procedures whenever permanent sutures and long-term care are not needed. Unfortunately, both inflammatory responses and adverse local tissue reactions in the close-to-stitching environment are often reported for biodegradable polymeric sutures currently used by the medical community. While bioabsorbable metals are predominantly investigated and tested for vascular stent or osteosynthesis applications, they also appear to possess adequate bio-compatibility, mechanical properties, and corrosion stability to replace biodegradable polymeric sutures. In this Review, biodegradable alloys made of iron, magnesium, and zinc are critically evaluated as potential materials for the manufacturing of soft and hard tissue sutures. In the case of soft tissue closing and stitching, these metals have to compete against currently available degradable polymers. In the case of hard tissue closing and stitching, biodegradable sternal wires could replace the permanent sutures made of stainless steel or titanium alloys. This Review discusses the specific materials and degradation properties required by all suture materials, summarizes current suture testing protocols and provides a well-grounded direction for the potential future development of biodegradable metal based sutures.

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Effect of the addition of low rare earth elements (lanthanum, neodymium, cerium) on the biodegradation and biocompatibility of magnesium

Cited by 209 publications

References 44 publications

In vivo evaluation of a magnesium-based degradable intramedullary nailing system in a sheep model

In vivo evaluation of a magnesium-based degradable intramedullary nailing system in a sheep model

Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy

Recent Advances in Biodegradable Metals for Medical Sutures: A Critical Review

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