Effect of Tafluprost 0.0015% on Central Corneal Thickness in Patients With Primary Open-angle Glaucoma

Panos, Georgios D; Konstantinidis, Aristeidis; Mendrinos, Efstratios; Kozobolis, Vassilios; Perente, İrfan; Gatzioufas, Zisis

doi:10.3109/02713683.2013.801495

Cited by 20 publications

(22 citation statements)

References 20 publications

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“…Furthermore, no significant correlation was found between CCT loss and IOP reduction in the NTG group (r = 0.16, P = 0.32), which is consistent with previous studies. 25,26 Based on Ehlers' IOP correction formula, we expected 0.61 mmHg of IOP underestimation for a CCT reduction of 8.6 mm, which accounts for 20% of the total IOP reduction (3.07 mmHg) observed after 60 months of latanoprost treatment. Presumably because the IOP-lowering effects of latanoprost exceeded the effect of CCT reduction, IOP reduction seemed not to affect CCT thinning in our study.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Effect of Latanoprost on Central Corneal Thickness in Normal-Tension Glaucoma: Five-Year Follow-Up Results

LeeHyungwoo

Joo

2015

Journal of Ocular Pharmacology and Therapeutics

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Section: Discussionmentioning

confidence: 99%

Long-Term Effect of Latanoprost on Central Corneal Thickness in Normal-Tension Glaucoma: Five-Year Follow-Up Results

LeeHyungwoo

Joo

2015

Journal of Ocular Pharmacology and Therapeutics

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“…Prostaglandin analogue (PGA) topical drops can decrease, increase, or not affect CCT. The decrease appears to occur most significantly in the first 1-2 years of treatment and mostly in NTG patients (range: 8.6 + /−5.2 to 14.24 + /−8.18 µm) [93][94][95]. This appears reversible following cessation [96].…”

Section: Topical Medicationsmentioning

confidence: 94%

The thick and thin of the central corneal thickness in glaucoma

Belovay

Goldberg

2018

Eye

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Central corneal thickness (CCT) is an important parameter in the assessment of any potential glaucoma patient. While it affects prognosis in ocular hypertension, its value in patients diagnosed with glaucoma is less certain. There are several biological factors and genetic components that may influence glaucoma progression, which have been associated with thinner CCT. The CCT itself can be affected by several factors including ethnicity, age, sex, glaucoma medications, genetics, and the subtype of glaucoma. Besides, there is variability in the measurement of CCT between difference types of devices. These factors need to be considered in the evaluation of glaucoma patients' CCT and its effect on interpretation of intraocular pressure levels and risk stratification.

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“…; Panos et al. ). The precise explanation for these changes is unknown, but it is well established that prostaglandins exert their IOP‐lowering effect by inducing extracellular matrix remodelling in key elements of the aqueous outflow system of the eye, most notably the uveoscleral pathway (Ocklind ; Kim et al.…”

Section: Introductionmentioning

confidence: 98%

Latanoprost treatment differentially affects intraocular pressure readings obtained with three different tonometers

Sánchez-Barahona

Bolívar

Katsanos

et al. 2019

Acta Ophthalmologica

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Purpose: To evaluate the apparent intraocular pressure (IOP) change observed after treatment with latanoprost in naive eyes of patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT) using Goldmann applanation tonometer (GAT), ocular response analyzer (ORA) and Corvis ST tonometry. Methods: Prospective observational cohort study. One eye from each of 59 newly diagnosed patients with POAG or OHT in our institution was analysed. IOP readings obtained using GAT, ORA and Corvis at baseline and after a 3month period of treatment with latanoprost were compared. Additionally, preand post-treatment biomechanical corneal parameters provided by the Corvis tonometer were analysed. Results: There was no statistically significant difference between the apparent treatment-induced IOP reductions when GAT and ORA were compared (p > 0.05). In contrast, the treatment-induced IOP reduction recorded using the Corvis tonometer was significantly smaller compared to the apparent IOP reduction observed with GAT and ORA (p = 0.0001 for both comparisons). With respect to biomechanical corneal properties, statistically significant changes were found after 3 months of treatment with latanoprost for the first corneal applanation time (AT1) (p = 0.001), second corneal applanation time (AT2) (p = 0.001) and deformation amplitude (DA) (p = 0.0003). Conclusion: Following a 3-month course of latanoprost, the apparent treatmentinduced IOP reduction in previously na€ ıve patients with POAG or OHT differed depending on the tonometer used. Certain corneal biomechanical parameters assessed using Corvis ST exhibited a significant change. The ocular hypotensive effect of prostaglandin analogues may be overestimated when chronically treated patients are measured using GAT or ORA.

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Effect of Tafluprost 0.0015% on Central Corneal Thickness in Patients With Primary Open-angle Glaucoma

Abstract: Long-term use of tafluprost may decrease the CCT in patients with POAG. Consequently, clinicians must be aware of prolongated CCT variations that may arise throughout the follow-up period for proper IOP targeting and management.

Cited by 20 publications

References 20 publications

Long-Term Effect of Latanoprost on Central Corneal Thickness in Normal-Tension Glaucoma: Five-Year Follow-Up Results

Long-Term Effect of Latanoprost on Central Corneal Thickness in Normal-Tension Glaucoma: Five-Year Follow-Up Results

The thick and thin of the central corneal thickness in glaucoma

Latanoprost treatment differentially affects intraocular pressure readings obtained with three different tonometers

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