Effect of Tacrolimus on Vitiligo in Absence of UV Radiation Exposure

Efficacy and safety of topical tacrolimus for the treatment of face and neck vitiligo

“…In Asia, Sardana et al. 11 reported the effects of tacrolimus in the absence of UV radiation in India. Our study is the first prospective study in Chinese with more patients enrolled.…”

Overview of medical therapies and phototherapy in vitiligo based on their pathogenetic action and the role of platelet-rich plasma

“…Only a substantial improvement on unexposed sites would be of clinical consequence, which was incidentally observed on mucosal sites with tacrolimus. [14]…”

Update on skin repigmentation therapies in vitiligo

“…Although it has been suggested that UVR treatment is not necessary to achieve repigmentation with tacrolimus (Sardana et al., 2007), excimer laser has been claimed to enhance the pigmentary response (Ostovari et al., 2006). Pimecrolimus has also been successfully used in vitiligo although sometimes with conflicting results (Day and Lin, 2008) .…”

“…In addition, proliferation of both melanocytes and melanoblasts, as well as significantly enhanced stem cell factor (SCF) in vitro, and metalloproteinase-9 (MMP-9) activity -which is involved in cell migration-occur with tacrolimus-treated keratinocyte supernatants; these findings suggest the effects of tacrolimus on melanocyte growth and migration during repigmentation (Kang and Choi, 2006;Lan et al, 2005). Although it has been suggested that UVR treatment is not necessary to achieve repigmentation with tacrolimus (Sardana et al, 2007), excimer laser has been claimed to enhance the pigmentary response (Ostovari et al, 2006). Pimecrolimus has also been successfully used in vitiligo although sometimes with conflicting results (Day and Lin, 2008).…”