1994
DOI: 10.1001/archderm.130.11.1457
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Effect of tacrolimus (FK506) in dystrophic epidermolysis bullosa: rationale and preliminary results

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Cited by 8 publications
(3 citation statements)
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“…But surprisingly is also augments cell regeneration and repair in sub-immunosuppressive dosages (Francavilla et al , 1989; Carroll et al , 1994; Gold, 1997). Low dosages (0.1 mg kg -1 ), but not standard immune-suppressive dosages (1.0 mg kg -1 ) of Tacrolimus promoted healing of colon anastomoses in rats (Kiyama et al , 2002).…”
Section: Discussionmentioning
confidence: 99%
“…But surprisingly is also augments cell regeneration and repair in sub-immunosuppressive dosages (Francavilla et al , 1989; Carroll et al , 1994; Gold, 1997). Low dosages (0.1 mg kg -1 ), but not standard immune-suppressive dosages (1.0 mg kg -1 ) of Tacrolimus promoted healing of colon anastomoses in rats (Kiyama et al , 2002).…”
Section: Discussionmentioning
confidence: 99%
“…[29][30][31][32] Additionally, FK506 possesses various non-immunological effects, including stimulating hair growth in mammals, promoting liver cell regeneration and wound healing in humans and promoting neuronal overgrowth. [33][34][35][36][37][38] However, recent research has extended its potential application beyond the immune system to the central nervous system (CNS), where microglial cells, as the resident immune defenders, play a pivotal role in maintaining CNS homeostasis and responding to pathological insults. Furthermore, FK506 has demonstrated neuroprotective potential against various cytotoxic triggers in several cell culture models, including primary neurons, PC12 cells (a cell line derived from a pheochromocytoma of the rat adrenal medulla), Neuro 2A (a mouse neuroblastoma cell line), SH-SY5Y (a human neuroblastoma cell line), NG 108-15 (neuroblastoma-glioma hybrid cells) and macrophages.…”
Section: Introductionmentioning
confidence: 99%
“…FK506 exerts immunosuppressive effects by inhibiting antigen‐specific T cell activation and the release of inflammatory cytokines 29–32 . Additionally, FK506 possesses various non‐immunological effects, including stimulating hair growth in mammals, promoting liver cell regeneration and wound healing in humans and promoting neuronal overgrowth 33–38 . However, recent research has extended its potential application beyond the immune system to the central nervous system (CNS), where microglial cells, as the resident immune defenders, play a pivotal role in maintaining CNS homeostasis and responding to pathological insults.…”
Section: Introductionmentioning
confidence: 99%