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Cited by 201 publications
(115 citation statements)
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References 32 publications
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“…3,4 Several recent trials have sought to determine whether intensive lowering of BP acutely improves outcomes in patients with ICH. [5][6][7][8][9][10] Over the last several years, a growing number of studies have characterized the presence and frequency of ischemic lesions remote from the acute hematoma visualized on diffusion-weighted imaging (DWI) in patients with primary ICH undergoing MRI. [11][12][13][14][15][16][17][18][19] Across these series, remote DWI lesions are visualized in 11%-41% of patients.…”
mentioning
confidence: 99%
“…3,4 Several recent trials have sought to determine whether intensive lowering of BP acutely improves outcomes in patients with ICH. [5][6][7][8][9][10] Over the last several years, a growing number of studies have characterized the presence and frequency of ischemic lesions remote from the acute hematoma visualized on diffusion-weighted imaging (DWI) in patients with primary ICH undergoing MRI. [11][12][13][14][15][16][17][18][19] Across these series, remote DWI lesions are visualized in 11%-41% of patients.…”
mentioning
confidence: 99%
“…Recent Phase 2 clinical trials evaluating acute BP control have shown promise in reducing hematoma expansion with an adequate safety profile and Phase 3 trials are underway. 8,9 Besides hematoma growth, other pathophysiological processes occur in the setting of ICH and may serve as potential therapeutic targets. In the acute period after ICH, a rapid rise in intracranial pressure (ICP) from an expanding hematoma may reduce cerebral perfusion pressure.…”
mentioning
confidence: 99%
“…In conclusion, contemporary studies have demonstrated the ability of prothrombotic and antihypertensive modalities to reduce ICH enlargement, but not to alter clinical outcome [Qureshi et al 2010;Anderson et al 2008;Mayer et al 2008Mayer et al , 2005. This paradox may be explained by the magnitude of hematoma volume difference achieved between the treatment and placebo arms.…”
Section: Summary and Future Strategiesmentioning
confidence: 86%