Effect of sugarcane biopolymer gel injected in rabbit vocal fold

Leão, Rodrigo Augusto de Souza; Assis, Raquel Coelho de; Neto, Sílvio da Silva Caldas; Lira, Mariana Montenegro de Melo; Vasconcelos, Silvio José de

doi:10.1016/j.bjorl.2014.02.003

Cited by 4 publications

(5 citation statements)

References 20 publications

(22 reference statements)

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“…The effect of biopolymer gel derived from sugarcane on healing of traumatic oral ulcers: an experimental study membranes, sponges, granules, and prostheses, has been extensively studied for application in the medical industry 10 . During the experiments, no clinical signs of infection, allergies, intoxication, or tissue extrusion were observed 7,11,12 .…”

Section: Introductionmentioning

confidence: 93%

The effect of biopolymer gel derived from sugarcane on healing of traumatic oral ulcers: an experimental study

Barbosa,

Oliveira,

Queiroz

et al. 2024

Acta Cir. Bras.

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Purpose: The extracellular polysaccharide (EPS) is produced by the bacterium Zoogloea sp. and plays a positive role in tissue repair. The purpose of this study was to clinically and histologically compare the effects of EPS in the healing of traumatic oral ulcers in rats with the effects of triamcinolone. Methods: Ulcers were induced in the oral mucous of 45 male Wistar rats, divided into three groups: control group, treated with triamcinolone, and treated with biopolymer gel. In the clinical evaluation, we considered the weight variation of the animals and the size of the lesion area, at baseline and on treatment days 1, 3 and 7. The histological parameters evaluated were the type and intensity of the inflammatory infiltration, the presence of necrosis and foreign body granuloma and the degree of re-epithelialization of the lesion. Results: The reduction of the lesion area was greater in the animals treated with EPS, with no difference in the intensity of the inflammatory infiltration between the groups on days 3 and 7 of treatment. Conclusions: The results suggest that topical application of EPS in traumatic oral ulcers of rats promotes faster repair than triamcinolone ointment, without increasing the intensity of inflammatory infiltration under the lesion.

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Section: Introductionmentioning

confidence: 93%

The effect of biopolymer gel derived from sugarcane on healing of traumatic oral ulcers: an experimental study

Barbosa,

Oliveira,

Queiroz

et al. 2024

Acta Cir. Bras.

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“…In both cases the SCB was replaced by collagen fibers, which retained at least partially the mass effect of the substance on the applied site 17,18 . In a recent work, Leão et al 19 studied the inflammatory reaction caused by the injection of the vocal fold SCB in rabbits. The authors observed that the polymer had rheological characteristics compatible with use in long-term treatment of glottal insufficiency.…”

Section: Introductionmentioning

confidence: 99%

Effect of sugarcane biopolymer in vocal fold of rabbits. Comparative study with calcium hydroxyapatite

Vasconcelos

Leão²,

Bernardino-Araújo

et al. 2015

Acta Cir. Bras.

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PURPOSE:To compare the inflammatory reaction caused by the injection of a sugarcane biopolymer (SCB) into the vocal fold of rabbits with that caused by calcium hydroxyapatite (CaH). METHODS:CaH (Radiesse ® ) and SCB gel were injected respectively into the right and left vocal cords of thirty rabbits. The rabbits were distributed into two equal groups and sacrificed at three and twelve weeks after injection. We then evaluated the intensity of the inflammatory reaction, plus levels of neovascularization, fibrogenesis and inflammatory changes in the vocal mucosa. RESULTS:The vocal cords injected with CaH had a stronger inflammatory reaction by giant cells in both study periods. The SCB group had a more intense inflammatory involvement of polymorphonuclear cells three weeks after injection. SCB caused a higher level of neovascularization compared with CaH three weeks after the procedure. CONCLUSION:Whereas calcium hydroxyapatite triggers a more intense and lasting inflammatory reaction mediated by giant cells, sugarcane biopolymer causes a greater response from polymorphonuclear leukocytes, as well as higher levels of vneoascularization three weeks after injection.

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“…Soma-se a isso o fato desse animal ser dócil e de fácil manuseio. Além disso, a literatura mostra outros trabalhos que utilizaram coelhos como modelo animal para estudo de enxertos para pregas vocais (4,36,41,42) . O simples espessamento desse epitélio ou, nos casos mais graves, a ulceração ou formação de granulomas, pode ter um impacto negativo muito importante na qualidade vocal após uma IL.…”

Section: Delineamento Do Estudo E Metodologiaunclassified

“…O simples espessamento desse epitélio ou, nos casos mais graves, a ulceração ou formação de granulomas, pode ter um impacto negativo muito importante na qualidade vocal após uma IL. Em outros estudos (4,26,36,41,42) foi utilizada a reação inflamatória ao material aplicado cirurgicamente dentro da prega vocal, como fator preditivo para os resultados funcionais do material em questão. A presença de uma reação inflamatória excessiva ao material escolhido para a IL era ligada a complicações, insucessos nesse procedimento e má qualidade vocal com vários materiais, incluindo a HCa (3,24) .…”

Section: Delineamento Do Estudo E Metodologiaunclassified

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Efeito da injeção do biopolímero da cana-de-açúcar na prega vocal de coelhos: estudo comparativo com a hidroxiapatita de cálcio

Vasconcelos¹

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Effect of sugarcane biopolymer gel injected in rabbit vocal fold

Abstract: We show that in spite of producing an inflammatory reaction in vocal fold tissues, the material remained in vocal fold throughout the study period.

Cited by 4 publications

References 20 publications

The effect of biopolymer gel derived from sugarcane on healing of traumatic oral ulcers: an experimental study

The effect of biopolymer gel derived from sugarcane on healing of traumatic oral ulcers: an experimental study

Effect of sugarcane biopolymer in vocal fold of rabbits. Comparative study with calcium hydroxyapatite

Efeito da injeção do biopolímero da cana-de-açúcar na prega vocal de coelhos: estudo comparativo com a hidroxiapatita de cálcio

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