Effect of stenting after laryngotracheal reconstruction in a subglottic stenosis model☆☆☆

Jewett, Brian S.; Cook, Raymond D.; Johnson, Kenneth L.; Logan, Thomas C.; Shockley, W.

doi:10.1016/s0194-5998(00)70089-1

Cited by 13 publications

(23 citation statements)

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“…In addition, post- Many different models have been used to study tracheal stenosis in animals [8][9][10][11][12][13][14][15] and investigators have long suspected that the extent of cartilaginous injury may be an important factor in the development of tracheal stenosis. There is evidence that in experimental settings of prolonged tracheal intubation, extensive cartilaginous injury is essential for the development of tracheal stenosis [8][9][10].…”

Section: Discussionmentioning

confidence: 99%

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Tracheal Stenosis Depends on the Extent of Cartilaginous Injury in Experimental Canine Model

Kwon

Suh

Chung

et al. 2003

Experimental Lung Research

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To test the hypothesis that the development of tracheal stenosis would depend on the extent of tracheal cartilaginous injury, either 90 degrees (n=6) or 180 degrees (n=6) of anterior wall of 4 tracheal rings were cauterized in 12 mongrel dogs using Nd-YAG laser. Beginning at 3 weeks after cauterization, 180 degrees tracheal injury resulted in life-threatening tracheal stenosis whereas 90 degrees injury did not. Gross and microscopic examinations showed that after 180 degrees injury, tracheal stenosis was accompanied by the loss of tracheal cartilage and dense fibrosis. These results indicate that tracheal stenosis depends on the extent of tracheal injury in experimental canine model.

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Section: Discussionmentioning

confidence: 99%

“…From previous experiments using animal model of prolonged intubation, extensive cartilaginous injury was essential for tracheal stenosis [8][9][10][11][12]. In addition, Charous and colleagues found that circumferential scarring as a result of circumferential endotracheal laser treatment was another important factor for tracheal narrowing [10].…”

mentioning

confidence: 99%

Tracheal Stenosis Depends on the Extent of Cartilaginous Injury in Experimental Canine Model

Kwon

Suh

Chung

et al. 2003

Experimental Lung Research

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“…Schon von daher reduziert ein Stent den effektiven Atemwegsquerschnitt und birgt das Risiko einer Sekundärschädigung der Schleimhaut in sich. Diese klinische Erfahrung wird durch aktuelle Tierexperimente bestätigt [107].…”

Section: Stabilisierungunclassified

Gestörte Funktion der oberen AtemwegeLaryngeale Atmung

Müller¹

2005

Laryngorhinootologie

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“…The direct lesion of the mucosa of the subglottic region due to abrasion [17,18], the applications of chemical agents [19] or endoscopic-controlled electrocoagulation [20] are the experimental techniques mostly used. However, even though there are various SGS experimental induction endoscopic models, there is still no consensus about the ideal model [21].…”

Section: Introductionmentioning

confidence: 99%

Electrocautery versus 23% NaOH infiltration to induce subglottic stenosis in a canine experimental model

et al. 2007

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Subglottic stenosis (SGS) is defined as the narrowing of the lower larynx. Difficulties in the management of subglottic stenosis, especially in the pediatric population, justify the development of experimental models. The objective of this study was to compare the two methods of experimental subglottic stenosis induction. Twenty-three dogs were randomly selected and assigned by lottery to either one of the two groups: Gp I (n = 10) of electrocoagulation; and Gp II (n = 13) of 23% NaOH injection. In Gp I, self-interruption electrocoagulation was applied to one point in each of the four quadrants of the cricoid cartilage. In Gp II, 0.2 ml of 23% NaOH was injected in the submucosal layer in the anterior and posterior portions of the cricoid cartilage. Once a week, endoscopy was performed and the caliber of the subglottic region was measured using endotracheal tubes, and the injection was repeated if there were no signs of subglottic stenosis. The animals were killed on day 21; animals that developed respiratory distress were killed before day 21. One animal in Gp I died on day 14 after the injection and during transportation; two animals in Gp II died, one on day 7 due to a tracheoesophageal fistula, and the other of unknown causes on day 5. Significant subglottic stenosis (over 51% obstruction) was found in 67% of the animals in Gp I and in 64% of those in Gp II (P = 0.99). Median time to development of significant stenosis was 21 days in both groups, and required either two or three injections. Mean time for the performance of the procedures was significantly shorter (P < 0.01) in Gp I (mean: 6.36 min) than in Gp II (mean: 14.88 min). Electrocoagulation and 23% NaOH injection in the subglottic region were effective in the development of significant subglottic stenosis in dogs, both methods leading to stenosis in the same period of time and after the same number of procedures. However, electrocoagulation was the fastest method.

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Effect of stenting after laryngotracheal reconstruction in a subglottic stenosis model☆☆☆

Abstract: This analysis suggests that stenting does not inhibit graft vascularization in the early postoperative period after LTR; however, complications were seen in the stented group at longer time intervals.

Cited by 13 publications

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Tracheal Stenosis Depends on the Extent of Cartilaginous Injury in Experimental Canine Model

Tracheal Stenosis Depends on the Extent of Cartilaginous Injury in Experimental Canine Model

Gestörte Funktion der oberen AtemwegeLaryngeale Atmung

Electrocautery versus 23% NaOH infiltration to induce subglottic stenosis in a canine experimental model

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