Effect of Starvation and Refeeding on the Circadian Rhythms of Hematological and Clinico-biochemical Values, and Water Intake of Rats

Maejima, Kazuhito; Nagase, Sumi

doi:10.1538/expanim1978.40.3_389

Cited by 18 publications

(12 citation statements)

References 4 publications

(5 reference statements)

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“…The significant decreases in serum glucose and lipid concentrations were consistent with decreased intake and altered lipid metabolism during fasting and were similar to observations previously reported by other investigators 6,14–16 . Matsuzawa and Sakazume 10 reported that fasted rats had decreased serum concentrations of cholesterol and triglycerides after 16 and 24 hours, compared with rats having access to feed.…”

Section: Discussionsupporting

confidence: 91%

“…Alterations in AST activity were insignificant and did not correlate with ALT activity. Changes in ALP activity could be attributable to decreased production of the intestinal isoenzyme during fasting, as rat intestine is the major source of serum ALP 5,7,11,14,15,18,19 . Matsuzawa and Sakazume 10 also reported decreased serum activities of ALT and ALP in rats fasted for 16 hours when compared with rats having access to feed.…”

Section: Discussionmentioning

confidence: 99%

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Effect of fasting duration on clinical pathology results in Wistar rats

Kale

Joshi

Gohil

et al. 2009

Veterinary Clinical Pathol

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Effect of fasting duration on clinical pathology results in Wistar rats

Kale

Joshi

Gohil

et al. 2009

Veterinary Clinical Pathol

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“…These CAP/TAP-induced changes were considered to be the result of haemoconcentration and occurred in association with reduced diet and water consumption. Comparable changes in the blood of rats on limited diet and water consumptions have been described (Schwartz et al 1973;Boyne and Arthur 1990;Maejima and Nagase 1991;Zaporowska and Wasilewski 1991;Levin et al 1993), and similar findings were reported by Matsuzawa and Sakazume (1994) in the rat and dog.…”

Section: Discussionsupporting

confidence: 82%

Haemotoxicity of busulphan, doxorubicin, cisplatin and cyclophosphamide in the female BALB/c mouse using a brief regimen of drug administration

et al. 2010

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Many anticancer drugs are myelotoxic and cause bone marrow depression; however, generally, the marrow/blood returns to normal after treatment. Nevertheless, after the administration of some anti-neoplastic agents (e.g. busulphan, BU) under conditions as yet undefined, the marrow may begin a return towards normal, but normality may not be achieved, and late-stage/residual marrow injury may be evident. The present studies were conducted to develop a short-term mouse model (a 'screen') to identify late-stage/residual marrow injury using a brief regimen of drug administration. Female BALB/c mice were treated with BU, doxorubicin (DOX), cisplatin (CISPLAT) or cyclophosphamide (CYCLOPHOS) on days 1, 3 and 5. In 'preliminary studies', a maximum tolerated dose (MTD) for each drug was determined for use in 'main studies'. In main studies, mice were treated with vehicle (control), low and high (the MTD) dose levels of each agent. Necropsies were performed, and blood parameters and femoral/humeral nucleated marrow cell counts (FNCC/HNCC) were assessed on six occasions (from days 1 to 60/61 post-dosing). Late-stage/residual changes were apparent in BU-treated mice at day 61 post-dosing: RBC, Hb and haematocrit were reduced, mean cell volume/mean cell haemoglobin were increased and platelet and FNCC counts were decreased. Mice given DOX, CISPLAT and CYCLOPHOS, in general, showed no clear late-stage/residual effects (day 60/61). It was concluded that a brief regimen of drug administration, at an MTD, with assessment at day 60/61 post-dosing was a suitable short-term method/screen in the mouse for detecting late-stage/residual marrow injury for BU, a drug shown to exhibit these effects in man.

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“…2002). Related changes in the peripheral blood of rodents given limited water and diet have been described by other workers; Maejima & Nagase (1991), and Zaporowska & Wasilewski (1991) reported increased erythrocyte values in starved rats with reduced intakes of water, and Boyne & Arthur (1990) and Levin et al . (1993) described similar results in rats with lowered diet consumptions.…”

Section: Discussionsupporting

confidence: 70%

Studies on the haemotoxicity of chloramphenicol succinate in the Dunkin Hartley guinea pig

Turton¹,

Andrews

Havard

et al. 2002

Int J Experimental Path

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Summary. In man, chloramphenicol (CAP), induces two major haemotoxic effects. First, a reversible, dose-related reticulocytopenia and anaemia developing during treatment. Second, a non-dose-related aplastic anaemia (AA), developing weeks after treatment, is often irreversible and fatal. In previous studies, we developed a mouse model of the reversible reticulocytopenia/ anaemia using CAP succinate (CAPS); attempts to induce AA in the mouse with CAPS were unsuccessful; in the rat, CAPS induced only minimal haemotoxicity. We therefore wished to investigate haematological changes caused by CAPS in a third rodent, particularly in relation to the induction of significant`late stage' bone marrow depression (AA). Female guinea pigs were gavaged with CAPS in three experiments. In a dose ranging study, CAPS (at 2500 and 3500 mg/kg) was administered daily for 9 days, and blood examined at 1 day post dosing. CAPS induced increased erythrocyte values (an apparent haemoconcentration effect), and reduced reticulocytes and femoral marrow nucleated cell counts (FNCC). In a second experiment, CAPS was given at 333, 666 and 1000 mg/kg (13 days); haematological changes were compared with results from the initial study, with evidence of dose-related effects. In a final experiment, CAPS was administered (825 mg/ kg, 16 days) and blood studied at 1, 12, 28 and 63 days post dosing. At day 1, erythrocyte values were decreased (NS), and reticulocytes and FNCC were reduced; the marrow was hypocellular with erythroid depletion. At 12 and 28 days, values returned towards the normal range. At 63 days, parameters were normal. Thus, CAPS (825 mg/kg for 16 days) induced changes comparable to the reversible bone marrow depression seen in man; but there was no evidence of`late stage' (i.e. at 63 days) marrow depression, as would be seen in a developing or overt marrow aplasia (AA). The guinea pig (like the mouse) is a model for the early events, but is not a good model for CAPinduced AA in man.

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Effect of Starvation and Refeeding on the Circadian Rhythms of Hematological and Clinico-biochemical Values, and Water Intake of Rats

Cited by 18 publications

References 4 publications

Effect of fasting duration on clinical pathology results in Wistar rats

Effect of fasting duration on clinical pathology results in Wistar rats

Haemotoxicity of busulphan, doxorubicin, cisplatin and cyclophosphamide in the female BALB/c mouse using a brief regimen of drug administration

Studies on the haemotoxicity of chloramphenicol succinate in the Dunkin Hartley guinea pig

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