Effect of St John's wort on bone formation in the orthopaedically expanded premaxillary suture in rats: a histological study

Halıcıoğlu, Koray; Çörekçi, Bayram; Akkaş, İsmail; Irgın, Celal; Özan, Fatih; Yılmaz, Fahri; Türker, Arzu Uçar

doi:10.1093/ejo/cju028

Cited by 16 publications

(9 citation statements)

References 35 publications

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“…Compared with previous studies that tested plants with high antioxidant capacities such as Urtica dioica, 8 Ginkgo biloba, 11 and Hypericum perforatum, 12 the change in the number of osteoclasts and osteoblasts was similar to the current study. However, these plant extracts are made up of various components and, given the difficulty in obtaining scientific evidence, it was unclear which component has the greatest effect on bone formation.…”

Section: Discussionsupporting

confidence: 83%

“…The number of animals used in this study was lower than some previous studies. [7][8][9][10][11][12] For ethical reasons, the number of animals approved for scientific experiments must be justified and reasonable. 24 In this study, after the statistical power analysis, the number of animals was reduced to the minimum required to achieve a scientific goal.…”

Section: Discussionmentioning

confidence: 99%

“…9 More recently, researchers have studied antioxidants more closely due to their stimulatory effect on bone metabolism via osteoblastic stimulation. 7,[10][11][12] Salviae miltiorrhizae (danshen) is a plant belonging to the grass species, Labiatae Lagurus, which produces a new and special phenolic acid that is a watersoluble called salvianolic acid B (Sal B). [13][14][15][16] This has been historically used as an herbal remedy in traditional Chinese medicine to protect people from some diseases of the heart, 17 brain, 18 kidneys, 19 and lungs, 20 as well as cancers.…”

Section: Introductionmentioning

confidence: 99%

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Effect of salvianolic acid B on new bone formation in the orthopedically expanded suture:

Kayalar¹,

Deynek²,

Tok³

et al. 2020

The Angle Orthodontist

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Objectives To determine the effects of Salvianolic acid B (Sal B) on new bone formation in the orthopedically expanded premaxillary sutures in rats. Materials and Methods The sample consisting of Sprague Dawley rats (male, n = 14) was split in half by random selection: the experiment group (Sal B) and the control group. The premaxillary suture of each rat was expanded by bonding an open-loop spring to two maxillary incisors, each end to one tooth. A 5-day expansion period followed by a 12-day retention period was conducted. The 17-day intraperitoneal administration of Sal B was performed daily for the experiment group at a dose of 40 mg/kilo. The trial was completed after sacrificing the rats and dissection of the premaxillae for histological analysis. The amount of new bone, quantity of capillaries and intensity of inflammatory cells were histomorphometrically determined while the quantities of osteoblasts and osteoclasts were determined immunohistochemically. Results The Sal B group was significantly different from the control group and had greater quantities of new bone, capillaries, inflammatory cells, osteoblasts, and osteoclasts. Conclusions Salvianolic acid B displays a positive effect during premaxillary expansion with a greater number of capillaries potentially in association with higher bone formation and improved angiogenesis in rats.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of salvianolic acid B on new bone formation in the orthopedically expanded suture:

Kayalar¹,

Deynek²,

Tok³

et al. 2020

The Angle Orthodontist

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“…Mesenchymal cells located on the inner side of the cartilaginous tissue proliferate and differentiate into osteoblasts when the suture is expanded ( 5 ). Many new materials especially antioxidants were used in studies and showed that antioxidants increases the osteoblastic activity and bone metabolism ( 6 - 8 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of Royal Jelly on new bone formation in rapid maxillary expansion in rats

Özan¹,

Çörekçi²,

Toptaş³

et al. 2015

Med Oral

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BackgroundThe aim of this study was to evaluate the effects of long and short term systemic usage of royal jelly on bone formation in the expanded maxillary suture in a rat model.Material and MethodsTwenty eight Wistar albino rats were randomly divided into 4 equal groups: Control (C); Only Expansion (OE), Royal Jelly (RJ) group, Royal Jelly was given to rats by oral gavage only during the expansion and retention period; Royal Jelly plus Nursery (RJN) group, Royal Jelly was given to rats by oral gavage during their nursery phase of 40 days and during the retention period. After the 5 day expansion period was completed, the rats underwent 12 days of mechanical retention. All rats were sacrificed in same time. Histological examination was performed to determine the number of osteoclasts, number of osteoblasts, number of capillaries, inflammatory cell infiltration, and new bone formation.ResultsNew bone formation, number of osteoclasts, number of osteoblasts, and the number of capillaries in the expanded maxillary sutures were higher in the RJ and RJN groups than in the other groups. Statistical analysis also demonstrated that new bone formation and the number of osteoblasts was also highest in the RJN group.ConclusionsThe systemic administration of Royal Jelly in conjunction with rapid maxillary expansion may increase the quality of regenerated bone. Key words:Bone formation, rapid maxillary expansion, Royal jelly.

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“…Водный экстракт надземной части активировал регенерацию костной ткани при расширении среднего небного шва, проводимого при коррекции прикуса [156]. В эксперименте показано, что стандартизированный метанольный экстракт восстанавливал костные ткани челюсти на модели стресса [157], этанольный экстракт активировал восстановление клеток пульпы зубов [158], масляный экстракт способствовал заживлению костной ткани при внедрении трансплантата [159].…”

Section: эффективность экстрактов H Perforatum при поражениях челюстно-лицевой областиunclassified

Biological Activity of Hypericum Perforatum L. (Hypericaceae): A Review

Буданцев¹,

Prikhodko

Варганова³

et al. 2021

Farm. farmakol. (Pâtigorsk)

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Федеральное государственное бюджетное учреждение науки Ботанический институт им. В.Л. Комарова Российской академии наук (БИН РАН) 197376, Россия, г. Санкт-Петербург, ул. проф. Попова, 2 2 Федеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный химико-фармацевтический университет»

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Effect of St John's wort on bone formation in the orthopaedically expanded premaxillary suture in rats: a histological study

Abstract: Although more effective in long-term usage, systemic use of St John's wort hastens new bone regeneration at the premaxillary suture and may help prevent relapse after expansion.

Cited by 16 publications

References 35 publications

Effect of salvianolic acid B on new bone formation in the orthopedically expanded suture:

Effect of salvianolic acid B on new bone formation in the orthopedically expanded suture:

Effect of Royal Jelly on new bone formation in rapid maxillary expansion in rats

Biological Activity of Hypericum Perforatum L. (Hypericaceae): A Review

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