Effect of soxhlet and cold press extractions on the physico-chemical characteristics of roasted and non-roasted chia seed oils

Özcan, Mehmet Musa; Al‐Juhaimi, Fahad Y.; Ahmed, Isam A. Mohamed; Osman, Magdi A.; Gassem, Mustafa A.

doi:10.1007/s11694-018-9977-z

Cited by 31 publications

(16 citation statements)

References 32 publications

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“…The histopathological examination of cardiac tissue had shown cardiac injury in the form of intermuscular edema, myofibrillar loss, infiltration with inflammatory cells, vacuolization and cardiomyocytes degeneration. These histological findings are linked with the previously published data [ 19 , 30 ]. Pre-treatment with CSO had reduced DOX-induced histological alteration of cardiomyocytes as compared to those only treated with DOX.…”

Section: Discussionsupporting

confidence: 85%

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Chia Seed Oil Ameliorates Doxorubicin-Induced Cardiotoxicity in Female Wistar Rats: An Electrocardiographic, Biochemical and Histopathological Approach

et al. 2021

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Doxorubicin (DOX) is a potent anti-cancer antibiotic that was widely used for treatment of various cancers. It produces free radicals which result in extreme dose-limiting cardiotoxicity. This study investigated the cardioprotective potential of chia seed oil, an active polyphenolic nutraceutical against doxorubicin-induced cardiotoxicity in Wistar rats. Twenty-four female Wistar rats were divided into four groups (n = 6) which consist of normal control, DOX control, test-A and test-B group. Animals were prophylactically treated with two different doses of test drug, i.e. chia seed oil 2.5 ml/kg/day and 5 ml/kg/day in test-A and test-B groups orally for 7 days. Doxorubicin (25 mg/kg; single dose) was administered intraperitoneally to DOX control, Test-A and Test-B animals on the seventh day to induce cardiotoxicity. ECG analysis was done before and after treatment. Besides ECG, CK, CK-MB, LDH, AST, MDA and GSH were analyzed. DOX had significantly altered ECG, CK, CK-MB, LDH, AST, MDA and GSH. Pre-treatment with chia seed oil significantly alleviated DOX-induced ECG changes and also guarded against DOX-induced rise of serum CK, CK-MB and AST levels. Chia seed oil alleviated histopathological alteration in DOX-treated rats. It also significantly inhibited DOX-induced GSH depletion and elevation of MDA. The present study revealed that chia seed oil exerts cardioprotection against doxorubicin-induced cardiotoxicity in female Wistar rats. Our study opens the perspective to clinical studies to precisely consider chia seed oil as a potential chemoprotectant nutraceutical in the combination chemotherapy with doxorubicin to limit its cardiotoxicity.

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Section: Discussionsupporting

confidence: 85%

“…Extraction of oil from black Chia Seed was done at Bargi Naturals, Mysore, India using cold press extraction methods [ 19 ]. The oil was permitted to stand for a sedimentation time of 1 week after extraction to eliminate solid impurities.…”

Section: Methodsmentioning

confidence: 99%

Chia Seed Oil Ameliorates Doxorubicin-Induced Cardiotoxicity in Female Wistar Rats: An Electrocardiographic, Biochemical and Histopathological Approach

et al. 2021

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“…Selected specialty seed oils contain different patterns and amounts of tocols, predominantly γ‐tocopherol (Akin et al., 2018; Czaplicki et al., 2011; Dabrowski et al., 2018; Ghaleshahi et al., 2020; Górnaś et al., 2014; Jung et al., 2012; Kiczorowska et al., 2019; Kiralan et al., 2019; Montserrat‐de la Paz et al., 2014; Mufari et al., 2020; Özcan, 2019b; Przygoda & Wejnerowska, 2015; Ramadan et al., 2012; Rezig et al., 2012; Stevenson et al., 2007; Xu et al., 2020). Some specialty seed oils have been reported to contain small amounts of tocotrienols, such as chia seed (β and γ) (Özcan et al., 2019b), flaxseed (δ) (Ghaleshahi et al., 2020), perilla seed (α and δ) (Ghaleshahi et al., 2020), and pumkin seed (α, β, and γ) (Akin et al., 2018).…”

Section: Fat‐soluble Bioactives In Specialty Seed Oilsmentioning

confidence: 99%

Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

Alasalvar

Chang

Bolling

et al. 2021

Comp Rev Food Sci Food Safe

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Seeds play important roles in human nutrition and health since ancient time. The term “specialty” has recently been applied to seeds to describe high‐value and/or uncommon food products. Since then, numerous studies have been conducted to identify various classes of bioactive compounds, including polyphenols in specialty seeds. This review discusses nutrients, fat‐soluble bioactives, polyphenols/bioactives, antioxidant activity, bioavailability, health benefits, and safety/toxicology of commonly consumed eight specialty seeds, namely, black cumin, chia, hemp, flax, perilla, pumpkin, quinoa, and sesame. Scientific results from the existing literature published over the last decade have been compiled and discussed. These specialty seeds, having numerous fat‐soluble bioactives and polyphenols, together with their corresponding antioxidant activities, have increasingly been consumed. Hence, these specialty seeds can be considered as a valuable source of dietary supplements and functional foods due to their health‐promoting bioactive components, polyphenols, and corresponding antioxidant activities. The phytochemicals from these specialty seeds demonstrate bioavailability in humans with promising health benefits. Additional long‐term and well‐design human intervention trials are required to ascertain the health‐promoting properties of these specialty seeds.

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“…Özcan, Al‐Juhaimi, Ahmed, Osman, and Gassem () showed that chia oil obtained from roasted seeds presents lower content of α‐Tocopherol, β + γ‐Tocopherol, δ‐Tocopherol, β‐Tocotrienol, and γ‐Tocotrienol compared with nonroasted seeds, regardless of the method used to obtain the oil: cold press or Soxhlet extraction. Recent data showed that heat acts negatively on physical‐chemical and bioactive properties of chia oil, where the content of fatty acids and phenolic compounds was decreased by microwave roasting (Özcan, Al‐Juhaimi, Ahmed, Osman, & Gassem, ).…”

Section: Resultsmentioning

confidence: 99%

Chia seed (Salvia hispanica L.) effects and their molecular mechanisms on unbalanced diet experimental studies: A systematic review

Enes

Moreira

Silva

et al. 2020

Journal of Food Science

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The aim of this review was to compile evidence and understand chia seed effects on unbalanced diet animal studies and the molecular mechanisms on metabolic biomarker modulation. A systematic review was conducted in electronic databases, following PRISMA recommendations. Risk of bias and quality was assessed using SYRCLE toll and ARRIVE guidelines. Seventeen articles were included. Throughout the studies, chia's main effects are associated with AMPK modulation: improvement of glucose and insulin tolerance, lipogenesis, antioxidant activity, and inflammation. Details about randomization and allocation concealment were insufficient, as well as information about blind protocols. Sample size, chia dose, and number of animals evaluated for each parameter were found to be lacking information among the studies. Based on experimental study data, chia has bioactive potential, and its daily consumption may reduce the risk of chronic disease development, mainly due to the antioxidant, anti-inflammatory, hypoglycemic, and hypolipidemic effects of the seed.Practical Application: The consumption of chia seeds may improve lipid profile, insulin and glucose tolerance, and reduce risk of cardiovascular disease. Whole seed or its oil presents positive effect, but the effects of chia oil can act faster than the seed.

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Effect of soxhlet and cold press extractions on the physico-chemical characteristics of roasted and non-roasted chia seed oils

Cited by 31 publications

References 32 publications

Chia Seed Oil Ameliorates Doxorubicin-Induced Cardiotoxicity in Female Wistar Rats: An Electrocardiographic, Biochemical and Histopathological Approach

Chia Seed Oil Ameliorates Doxorubicin-Induced Cardiotoxicity in Female Wistar Rats: An Electrocardiographic, Biochemical and Histopathological Approach

Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

Chia seed (Salvia hispanica L.) effects and their molecular mechanisms on unbalanced diet experimental studies: A systematic review

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