Effect of solution environment on unstirred dead-end ultrafiltration characteristics of proteinaceous solutions.

Iritani, Eiji; Nakatsuka, Shuji; Aoki, Hiizu; Murase, Toshiro

doi:10.1252/jcej.24.177

Cited by 66 publications

(42 citation statements)

References 14 publications

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“…While membrane filtration is a key process which has the widespread application, it is generally recognized that one of the major drawbacks to more widespread use of membrane filtration is a significant increase in the filtration resistance known as membrane fouling, resulting in a dramatic flux decline over time under constant pressure conditions or a remarkable pressure rise over time under constant rate conditions. The membrane fouling is affected by several factors, e.g., pore blocking and/or pore constriction Bredée, 1935, 1936;Grace, 1956;Shirato et al, 1979;Hermia, 1982;Iritani et al, 1992Iritani et al, , 2009Iritani et al, , 2013, cake formation (Reihanian et al, 1983;Chudacek and Fane, 1984;Iritani et al, 1991aIritani et al, , 2014aNakakura et al, 1997;Mohammadi et al, 2005;Thekkedath et al, 2007;Sarkar, 2013;Salinas-Rodriguez et al, 2015), solute adsorption (Fane et al, 1983;Iritani et al, 1994), and concentration polarization (Kimura and Sourirajan, 1967;Vilker et al, 1981). Initially, foulants smaller than the pore size of membrane deposit or adsorb onto the pore walls, thereby leading to the pore constriction.…”

Section: Introductionmentioning

confidence: 99%

Developments of Blocking Filtration Model in Membrane Filtration

Iritani

Katagiri

2016

KONA

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118

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Blocking filtration laws consist of four different filtration mechanisms: complete blocking, standard blocking, intermediate blocking, and cake filtration. Blocking filtration laws for describing both the pore blocking and cake formation have been extensively employed over the past several decades to evaluate the increase in filtration resistance with the progress of filtration in the field of classical particulate filtration. In recent years, blocking filtration laws become widely used also in membrane filtration such as microfiltration and ultrafiltration of colloids. This paper gives an overview of the developments of blocking filtration laws and equations under constant pressure and constant rate conditions reported for the filtrate flow of Newtonian and non-Newtonian fluids. The fouling index evaluating the degree of membrane fouling was examined on the basis of the blocking filtration equations. The blocking filtration laws were reexamined to extend the range of their application. Moreover, various combined models developed based on the blocking filtration laws were introduced for describing more rigorously the complicated filtration behaviors controlled by more than one mechanism which occurs successively or simultaneously.

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Section: Introductionmentioning

confidence: 99%

Developments of Blocking Filtration Model in Membrane Filtration

Iritani

Katagiri

2016

KONA

Self Cite

118

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“…(15) and (16) where e av,ω is the average void ratio from the membrane surface to the distance w from the membrane. The thickness L of the protein filter cake is expressed based on the material balance as L҃ v (18) As shown in the figure, high specific filtration resistance can be obtained although the porosity in the cake is not so small [2,17]. The figure obviously demonstrates that both p s and a decrease with the distance x.…”

Section: Compressible Cake Filtration Modelmentioning

confidence: 99%

“…It is apparent that a around the isoelectric point is much smaller than that at pH 7 with the same solution concentration. On the other hand, the average specific filtration resistance a av of the cake in the ultrafiltration of BSA solutions reaches a definite maximum around the isoelectric point [2]. In order to account for this discrepancy, a high-speed sedimentation equilibrium experiment was conducted.…”

Section: Analysis Of Ultrafiltration Behaviors Based On Ultracentrifumentioning

confidence: 99%

“…The filtration behaviors are strongly affected by the properties of the filter cake formed by the accumulation of the particles and/or the macromolecules on the surface of the filter medium or the membrane [2]. Therefore, an understanding of the cake structure can serve as a basis for clarifying the real mechanism of cake filtration and membrane filtration.…”

Section: Introductionmentioning

confidence: 99%

“…(1), (2), and (4) by using the slope of the plot of dθ/dv against v and the value of m. The values of m and α av obtained by this method can be predicted by using the compression-permeability cell data. On the basis of the compressible cake filtration model [9,10], the distributions of the local porosity ε and the local specific filtration resistance a and the apparent liquid velocity u relative to solids in the filter cake can be estimated by using the compression-permeability cell data in the form of e and a as functions of the local solid compressive pressure p s .…”

Section: Introductionmentioning

confidence: 99%

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Properties of Filter Cake in Cake Filtration and Membrane Filtration

Iritani

2003

KONA

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It is extremely important from both theoretical and industrial viewpoints to develop simple and precise filtration test methods. The most commonly used tests are classified into three groups: vacuum filtration tests, pressure filtration tests, and compression-permeability tests. Such overall filtration characteristics as the average specific filtration resistance α av and the average ratio m of wet to dry cake mass are mea- Eiji Iritani

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Fractionation, Blood, Plasma Fractionation

Foster

2000

Kirk-Othmer Encyclopedia of Chemical Technology

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Blood plasma fractionation is a biopharmaceutical manufacturing operation in which high quality, proteinaceous products are prepared for clinical use from human plasma. Products prepared in this manner include albumin, eg, human serum albumin, and plasma protein fraction, for volume and protein replacement in surgery and for the treatment of injury and disease; coagulation factors, eg, Factor VIII and Factor IX Complex, for the prevention and treatment of bleeding disorders; and immunoglobulins, eg, immune serum globulin and immune globulin intravenous, for the prevention and treatment of infectious diseases and immune disorders. A number of highly integrated bioseparation processes are employed to fractionate human plasma into its different constituents. These range from established cold‐ethanol precipitation technology, devised in the 1940s, to more recently developed solid‐phase adsorption/desorption techniques. The principal developments since 1980 have been immunoglobulin products for intravenous use, and highly effective technologies for the inactivation of viral contaminants, such as hepatitis viruses and Human Immunodeficiency Virus (HIV), which were associated with earlier coagulation factor preparations.

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Effect of solution environment on unstirred dead-end ultrafiltration characteristics of proteinaceous solutions.

Cited by 66 publications

References 14 publications

Developments of Blocking Filtration Model in Membrane Filtration

Developments of Blocking Filtration Model in Membrane Filtration

Properties of Filter Cake in Cake Filtration and Membrane Filtration

Fractionation, Blood, Plasma Fractionation

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