Effect of sodium butyrate on metallothionein induction and cadmium cytotoxicity in ROS 17/2.8 cells

Gene expression within a chromatin domain: the role of core histone hyperacetylation

“…More typically, butyrate acts in the absence of protein biosynthesis. Prominent examples are constructs driven by the HIV long terminal repeat (Bohan et al, 1989), the metallothionein promoter (Birren & Herschman, 1986;Thomas et al, 1991), and the a-gonadotropin gene (Darnell, 1984). The only explanation that has been advanced so far for such a direct action of the fatty acid is the modification of a preexisting factor, although knowledge about the nature of such a process is lacking.…”

Gene expression within a chromatin domain: the role of core histone hyperacetylation

“…More typically, butyrate acts in the absence of protein biosynthesis. Prominent examples are constructs driven by the HIV long terminal repeat (Bohan et al, 1989), the metallothionein promoter (Birren & Herschman, 1986;Thomas et al, 1991), and the a-gonadotropin gene (Darnell, 1984). The only explanation that has been advanced so far for such a direct action of the fatty acid is the modification of a preexisting factor, although knowledge about the nature of such a process is lacking.…”

Biphasic Response of the Metallothionein Promoter to Ultraviolet Radiation in Human Melanoma Cells

“…Demethylation of DNA (19) or altered chromatin structure and consequent increased accessibility for transcription (35,36) are considered to account for MT induction by butyrate, but little is known about the action of ABHA. MT transcription is controlled by positively and negatively acting factors (15), and in the present study the latter may be synergistically increased by the combination of UV and differentiating agents acting on a common pathway.…”

Gene expression within a chromatin domain: the role of core histone hyperacetylation

“…More typically, butyrate acts in the absence of protein biosynthesis. Prominent examples are constructs driven by the HIV long terminal repeat (Bohan et al, 1989), the metallothionein promoter (Birren & Herschman, 1986;Thomas et al, 1991), and the a-gonadotropin gene (Darnell, 1984). The only explanation that has been advanced so far for such a direct action of the fatty acid is the modification of a preexisting factor, although knowledge about the nature of such a process is lacking.…”

Biphasic Response of the Metallothionein Promoter to Ultraviolet Radiation in Human Melanoma Cells

“…Demethylation of DNA (19) or altered chromatin structure and consequent increased accessibility for transcription (35,36) are considered to account for MT induction by butyrate, but little is known about the action of ABHA. MT transcription is controlled by positively and negatively acting factors (15), and in the present study the latter may be synergistically increased by the combination of UV and differentiating agents acting on a common pathway.…”

Gene expression within a chromatin domain: the role of core histone hyperacetylation

“…More typically, butyrate acts in the absence of protein biosynthesis. Prominent examples are constructs driven by the HIV long terminal repeat (Bohan et al, 1989), the metallothionein promoter (Birren & Herschman, 1986;Thomas et al, 1991), and the a-gonadotropin gene (Darnell, 1984). The only explanation that has been advanced so far for such a direct action of the fatty acid is the modification of a preexisting factor, although knowledge about the nature of such a process is lacking.…”

Biphasic Response of the Metallothionein Promoter to Ultraviolet Radiation in Human Melanoma Cells

“…Demethylation of DNA (19) or altered chromatin structure and consequent increased accessibility for transcription (35,36) are considered to account for MT induction by butyrate, but little is known about the action of ABHA. MT transcription is controlled by positively and negatively acting factors (15), and in the present study the latter may be synergistically increased by the combination of UV and differentiating agents acting on a common pathway.…”