Effect of smoking, alcohol, and depression on the quality of life of head and neck cancer patients

Duffy, Sonia A.; Terrell, Jeffrey E.; Valenstein, Marcia; Ronis, David L.; Copeland, Laurel A.; Connors, Mary E.

doi:10.1016/s0163-8343(02)00180-9

Cited by 183 publications

(151 citation statements)

References 44 publications

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“…Finally, a recent study (42) found that 13% of cancer patients who did not smoke in the 7 days before surgery had resumed smoking within 12 months after surgery; their resumption of smoking was related to a higher perceived difficulty of quitting and lower perceptions of their cancer-related risk. Research has shown that continued smoking after diagnosis has immediate adverse impacts, including reduced efficacy of cancer treatment (5,41), increased proportions of cancer stem-like cells (41), higher rates of treatment complications and side effects (43,44), higher treatment-related weight loss (45), and a poorer quality of life (46). Unfortunately, we did not collect data on the patients who resumed or continued smoking during treatment or follow-up in this study; therefore, the possibility that some former smokers resumed smoking during treatment or follow-up cannot be ignored.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Impact of Cigarette Smoking on the Survival of Patients with Established Nasopharyngeal Carcinoma

OuYang

Mao

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Cigarette smoking is associated with the etiology of nasopharyngeal carcinoma; however, the influence of smoking on survival in patients with established nasopharyngeal carcinoma remains unknown.Methods: We retrospectively analyzed 1,849 patients with nasopharyngeal carcinoma who were categorized as never, former, and current smokers. Cumulative effect of smoking was defined in terms of pack-years. Associations between cigarette exposure and survival were estimated by Cox proportional hazards model.Results: The risks of death, progression, locoregional relapse, and distant metastasis were significantly higher for former and current smokers (all P 0.002) than never smokers. Heavy smokers with high pack-years had HRs for death of 3.31 [95% confidence interval (CI), 2.58-4.26; P < 0.001], for progression of 2.53 (95% CI, 2.03-3.16; P < 0.001), and for distant metastasis of 2.65 (95% CI, 1.89-3.70; P < 0.001). Specifically, in the cohort of 495 patients treated with intensity-modulated radiotherapy/three-dimensional conformal radiotherapy, we obtained similarly significant results. All of the survival outcomes remained significant in multivariate analyses.Conclusions: Pretreatment cigarette smoking is an independent, poor prognostic factor for patients with nasopharyngeal carcinoma, which is associated with increased risk of death, progression, locoregional relapse, and distant metastasis, with the risk increasing with pack-years.Impact: It is clear that cigarette smoking not only promotes carcinogenesis in the normal nasopharyngeal epithelium, but also affects the survival of patients with nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev; 22(12); 2285-94. Ó2013 AACR.

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Section: Discussionmentioning

confidence: 99%

Prognostic Impact of Cigarette Smoking on the Survival of Patients with Established Nasopharyngeal Carcinoma

OuYang

Mao

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Patients who were former smokers by 1-year follow-up reported higher QOL than patients who had not stopped smoking. 36 Duffy and colleagues 9 also examined smoking behavior in head and neck cancer survivors and found that current smokers had significantly poorer physical functioning, general health perceptions, vitality, social functioning, and emotional functioning compared with nonsmokers. 9 In a more recent study, 11 continued smoking after lung cancer diagnosis was associated with lower QOL.…”

Section: Impact Of Smoking Cessation On Quality Of Lifementioning

confidence: 99%

Successes and failures of the teachable moment

Gritz

Fingeret

Vidrine

et al. 2005

Cancer

325

294

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Objective We utilized the amyloid imaging ligand Pittsburgh Compound B (PiB) to determine the presence of Alzheimer's disease (AD) pathology in different mild cognitive impairment (MCI) subtypes and to relate increased PiB binding to other markers of early AD and longitudinal outcome. Methods Twenty‐six patients with MCI (13 single‐domain amnestic‐MCI [a‐MCI], 6 multidomain a‐MCI, and 7 nonamnestic MCI) underwent PiB imaging. Twenty‐three had clinical follow‐up (21.2 ± 16.0 [standard deviation] months) subsequent to their PiB scan. Results Using cutoffs established from a control cohort, we found that 14 (54%) patients had increased levels of PiB retention and were considered “amyloid‐positive.” All subtypes were associated with a significant proportion of amyloid‐positive patients (6/13 single‐domain a‐MCI, 5/6 multidomain a‐MCI, 3/7 nonamnestic MCI). There were no obvious differences in the distribution of PiB retention in the nonamnestic MCI group. Predictors of conversion to clinical AD in a‐MCI, including poorer episodic memory, and medial temporal atrophy, were found in the amyloid‐positive relative to amyloid‐negative a‐MCI patients. Longitudinal follow‐up demonstrated 5 of 13 amyloid‐positive patients, but 0 of 10 amyloid‐negative patients, converted to clinical AD. Further, 3 of 10 amyloid‐negative patients “reverted to normal.” Interpretation These data support the notion that amyloid‐positive patients are likely to have early AD, and that the use of amyloid imaging may have an important role in determining which patients are likely to benefit from disease‐specific therapies. In addition, our data are consistent with longitudinal studies that suggest a significant percentage of all MCI subtypes will develop AD. Ann Neurol 2009;65:557–568

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“…Tobacco and alcohol use are well-known primary risk factors for developing head and neck cancer and have been shown to be associated with decreased quality-of-life scores 3,4 and decreased survival. 5 Diets high in fruits and vegetables are protective against most cancers of the head and neck, 6 can affect the occurrence of second primary cancers, 7 and are associated with reduced cancer mortality.…”

Section: Introductionmentioning

confidence: 99%

Pretreatment Health Behaviors Predict Survival Among Patients With Head and Neck Squamous Cell Carcinoma

Duffy

Ronis

McLean

et al. 2009

JCO

136

150

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A B S T R A C T PurposeOur prior work has shown that the health behaviors of head and neck cancer patients are interrelated and are associated with quality of life; however, other than smoking, the relationship between health behaviors and survival is unclear. Patients and MethodsA prospective cohort study was conducted to determine the relationship between five pretreatment health behaviors (smoking, alcohol, diet, physical activity, and sleep) and all-cause survival among 504 head and neck cancer patients. ResultsSmoking status was the strongest predictor of survival, with both current smokers (hazard ratio [HR] ϭ 2.4; 95% CI, 1.3 to 4.4) and former smokers (HR ϭ 2.0; 95% CI, 1.2 to 3.5) showing significant associations with poor survival. Problem drinking was associated with survival in the univariate analysis (HR ϭ 1.4; 95% CI, 1.0 to 2.0) but lost significance when controlling for other factors. Low fruit intake was negatively associated with survival in the univariate analysis only (HR ϭ 1.6; 95% CI, 1.1 to 2.1), whereas vegetable intake was not significant in either univariate or multivariate analyses. Although physical activity was associated with survival in the univariate analysis (HR ϭ 0.95; 95% CI, 0.93 to 0.97), it was not significant in the multivariate model. Sleep was not significantly associated with survival in either univariate or multivariate analysis. Control variables that were also independently associated with survival in the multivariate analysis were age, education, tumor site, cancer stage, and surgical treatment. ConclusionVariation in selected pretreatment health behaviors (eg, smoking, fruit intake, and physical activity) in this population is associated with variation in survival.

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Effect of smoking, alcohol, and depression on the quality of life of head and neck cancer patients

Cited by 183 publications

References 44 publications

Prognostic Impact of Cigarette Smoking on the Survival of Patients with Established Nasopharyngeal Carcinoma

Prognostic Impact of Cigarette Smoking on the Survival of Patients with Established Nasopharyngeal Carcinoma

Successes and failures of the teachable moment

Pretreatment Health Behaviors Predict Survival Among Patients With Head and Neck Squamous Cell Carcinoma

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