Effect of Size and Surface Charge of Gold Nanoparticles on their Skin Permeability: A Molecular Dynamics Study

Gupta, Rakesh; Rai, Beena

doi:10.1038/srep45292

Cited by 176 publications

(150 citation statements)

References 60 publications

Supporting

Mentioning

138

Contrasting

Unclassified

Order By: Relevance

“…For example, sunscreens containing ZnONPs and TiO 2 NPs are effective barriers against ultraviolet light (UV-light) damage to skin and do not leave white or other residues on the skin [131,132]. AgNPs are used in toothpaste and soap and other cleaning products to achieve an antibacterial effect, and gold nanoparticles (AuNPs) are commonly used as carriers that easily penetrate the skin [132][133][134]. However, the diversity of NMs applied in cosmetics has raised concerns about their potential risks.…”

Section: Zno Nanoparticles-induced Toxicity and The Possible Role Of mentioning

confidence: 99%

The Current Understanding of Autophagy in Nanomaterial Toxicity and Its Implementation in Safety Assessment-Related Alternative Testing Strategies

Chen

Liao

et al. 2020

IJMS

View full text Add to dashboard Cite

Nanotechnology has rapidly promoted the development of a new generation of industrial and commercial products; however, it has also raised some concerns about human health and safety. To evaluate the toxicity of the great diversity of nanomaterials (NMs) in the traditional manner, a tremendous number of safety assessments and a very large number of animals would be required. For this reason, it is necessary to consider the use of alternative testing strategies or methods that reduce, refine, or replace (3Rs) the use of animals for assessing the toxicity of NMs. Autophagy is considered an early indicator of NM interactions with cells and has been recently recognized as an important form of cell death in nanoparticle-induced toxicity. Impairment of autophagy is related to the accelerated pathogenesis of diseases. By using mechanism-based high-throughput screening in vitro, we can predict the NMs that may lead to the generation of disease outcomes in vivo. Thus, a tiered testing strategy is suggested that includes a set of standardized assays in relevant human cell lines followed by critical validation studies carried out in animals or whole organism models such as C. elegans (Caenorhabditis elegans), zebrafish (Danio rerio), and Drosophila (Drosophila melanogaster)for improved screening of NM safety. A thorough understanding of the mechanisms by which NMs perturb biological systems, including autophagy induction, is critical for a more comprehensive elucidation of nanotoxicity. A more profound understanding of toxicity mechanisms will also facilitate the development of prevention and intervention policies against adverse outcomes induced by NMs. The development of a tiered testing strategy for NM hazard assessment not only promotes a more widespread adoption of non-rodent or 3R principles but also makes nanotoxicology testing more ethical, relevant, and cost- and time-efficient.

show abstract

Section: Zno Nanoparticles-induced Toxicity and The Possible Role Of mentioning

confidence: 99%

The Current Understanding of Autophagy in Nanomaterial Toxicity and Its Implementation in Safety Assessment-Related Alternative Testing Strategies

Chen

Liao

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…They reported that topically applied siRNA‐coated AuNPs could be successfully employed for gene regulation . Moreover, our group among others has systematically studied the interactions of functionalized gold nanoparticles with healthy and damaged skin tissue and found that size, surface charge, as well as functional ligands on nanoparticles play key roles in penetration and interactions of nanoparticles with skin …”

Section: Introductionmentioning

confidence: 99%

Sensing of Vimentin mRNA in 2D and 3D Models of Wounded Skin Using DNA‐Coated Gold Nanoparticles

Vilela

Heuer‐Jungemann

El‐Sagheer

et al. 2018

Small

View full text Add to dashboard Cite

Wound healing is a highly complex biological process, which is accompanied by changes in cell phenotype, variations in protein expression, and the production of active biomolecules. Currently, the detection of proteins in cells is done by immunostaining where the proteins in fixed cells are detected by labeled antibodies. However, immunostaining cannot provide information about dynamic processes in living cells, within the whole tissue. Here, an easy method is presented to detect the transition of epithelial to mesenchymal cells during wound healing. The method employs DNA-coated gold nanoparticle fluorescent nanoprobes to sense the production of Vimentin mRNA expressed in mesenchymal cells. Fluorescence microscopy is used to achieve temporal detection of Vimentin mRNA in wounds. 3D light-sheet microscopy is utilized to observe the dynamic expression of Vimentin mRNA spatially around the wounded site in skin tissue. The use of DNA-gold nanoprobes to detect mRNA expression during wound healing opens up new possibilities for the study of real-time mechanisms in complex biological processes.

show abstract

“…These mechanisms have even been studied by molecular dynamics simulations. These novel studies have provided a huge opportunity to create nanoparticles for use in the cosmetic field and for transdermal drug delivery [135]. Recently, the photothermal-based antibacterial activity of gold nanorods (AuNRs) coated with cholesterol-PEG and phospholipid-PEG were tested on human skin.…”

Section: Antibacterialmentioning

confidence: 99%

Nanoengineering of Gold Nanoparticles: Green Synthesis, Characterization, and Applications

et al. 2019

View full text Add to dashboard Cite

The fundamental aspects of the manufacturing of gold nanoparticles (AuNPs) are discussed in this review. In particular, attention is devoted to the development of a simple and versatile method for the preparation of these nanoparticles. Eco-friendly synthetic routes, such as wet chemistry and biosynthesis with the aid of polymers, are of particular interest. Polymers can act as reducing and/or capping agents, or as soft templates leading to hybrid nanomaterials. This methodology allows control of the synthesis and stability of nanomaterials with novel properties. Thus, this review focus on a fundamental study of AuNPs properties and different techniques to characterize them, e.g., Transmission Electron Microscopy (TEM), Atomic Force Microscopy (AFM), UV-Visible spectroscopy, Dynamic Light Scattering (DLS), X-Ray Diffraction (XRD), X-Ray Photoelectron Spectroscopy, Small-angle X-Ray Scattering (SAXS), and rheology. Recently, AuNPs obtained by “green” synthesis have been applied in catalysis, in medicine, and as antibacterials, sensors, among others.

show abstract

Effect of Size and Surface Charge of Gold Nanoparticles on their Skin Permeability: A Molecular Dynamics Study

Cited by 176 publications

References 60 publications

The Current Understanding of Autophagy in Nanomaterial Toxicity and Its Implementation in Safety Assessment-Related Alternative Testing Strategies

The Current Understanding of Autophagy in Nanomaterial Toxicity and Its Implementation in Safety Assessment-Related Alternative Testing Strategies

Sensing of Vimentin mRNA in 2D and 3D Models of Wounded Skin Using DNA‐Coated Gold Nanoparticles

Nanoengineering of Gold Nanoparticles: Green Synthesis, Characterization, and Applications

Contact Info

Product

Resources

About