2010
DOI: 10.1590/s0102-86502010000600006
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: Sildenafil had a protective effect in rat kidneys subjected to normothermic I/R, demonstrated by scintigraphy and histomorphometry.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

5
13
0

Year Published

2011
2011
2017
2017

Publication Types

Select...
4

Relationship

1
3

Authors

Journals

citations
Cited by 34 publications
(34 citation statements)
references
References 24 publications
(34 reference statements)
5
13
0
Order By: Relevance
“…There was a trend towards a reduction in proinflammatory cytokines in tadalafil treated rats compared to I/R saline group. Besides an overall decreased inflammatory profile, we observed that tadalafil improved fasting plasma urea, creatinine and C-reactive protein levels, and our results correlate with previously published data and known physiological pathways 19,25 . According to the literature, renal ischemia duration of 45 to 75 minutes is most commonly chosen in experimental models, because this ischemia time allows for intermediate survival.…”
supporting
confidence: 91%
See 1 more Smart Citation
“…There was a trend towards a reduction in proinflammatory cytokines in tadalafil treated rats compared to I/R saline group. Besides an overall decreased inflammatory profile, we observed that tadalafil improved fasting plasma urea, creatinine and C-reactive protein levels, and our results correlate with previously published data and known physiological pathways 19,25 . According to the literature, renal ischemia duration of 45 to 75 minutes is most commonly chosen in experimental models, because this ischemia time allows for intermediate survival.…”
supporting
confidence: 91%
“…In a previous study we demonstrated that the pretreatment with sildenafil has a positive effect on I/R of kidneys of rats 19 .…”
mentioning
confidence: 87%
“…However, these authors examined the effects of Tadalafil pretreatment (60 min before I/R) on histological changes and oxidative stress in a model of 60 min of ischemia and 60 min of reperfusion without evaluation of kidney function. Similarly, Sildenafil, a short acting member of the PDE5 inhibitor family, was effective in preventing kidney dysfunction and preserving NO bioavailability in an I/R AKI model in rats (6,18,24) and in an experimental postcardiopulmonary bypass-induced AKI (25). The nephroprotective effects of Sildenafil are not restricted to I/R AKI, rather they are also evident in other AKI models such as cisplatin-induced nephrotoxicity (17).…”
Section: Discussionmentioning
confidence: 99%
“…Immediately after the surgical procedure was completed, the rats in the sham-operated and the SLDtreated CLP groups received 10-or 20-mg/kg doses of SLD, which were administered with an oral gavage suspended in saline. There are many sildenafil doses for rats, varying from 0·4 mg/kg to 90 mg/kg, with different administration routes [28][29][30][31][32][33]. The reason we selected 10-and 20-mg/kg doses of oral sildenafil is that 10 mg/kg/day of sildenafil would result approximately in the same plasma concentration as 50 mg in humans [34].…”
Section: Sepsis Modelmentioning
confidence: 99%