Effect of sex differences and gonadal hormones on kainic acid-induced neurodegeneration in the bed nucleus of the stria terminalis of the rat

Pereno, Germán Leandro; Balaszczuk, Verónica; Beltramino, C.

doi:10.1016/j.etp.2010.08.020

Cited by 5 publications

(5 citation statements)

References 51 publications

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“…Also, the SE induced by intrahippocampal kainate in NMRI mice was more severe in male than female mice, which could have affected the epileptogenic processes induced by SE in both genders [101]. Several previous studies reported that male rodents are more susceptible to the convulsive and neurodegenerative effects of systemic kainate administration than females, and a proconvulsive effect of testosterone and neuroprotective effect of estrogen was demonstrated [208-212]. However, Scharfman and MacLusky [198] reported that the SE induced by kainate was indistinguishable in male and female SD rats, and no significant difference in stages of the estrous cycle was found.…”

Section: Role Of Sex For Inter- and Intrastrain Differencesmentioning

confidence: 99%

The relevance of inter- and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy

Löscher¹,

Ferland

Ferraro

2017

Epilepsy & Behavior

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It is becoming increasingly clear that the genetic background of mice and rats, even in inbred strains, can have a profound influence on measures of seizure susceptibility and epilepsy. These differences can be capitalized upon through genetic mapping studies to reveal genes important for seizures and epilepsy. However, strain background and particularly mixed genetic backgrounds of transgenic animals need careful consideration in both the selection of strains and in the interpretation of results and conclusions. For instance, mice with targeted deletions of genes involved in epilepsy can have profoundly disparate phenotypes depending on the background strain. In this review, we discuss findings related to how this genetic heterogeneity has and can be utilized in the epilepsy field to reveal novel insights into seizures and epilepsy. Moreover, we discuss how caution is needed in regards to rodent strain or even animal vendor choice, and how this can significantly influence seizure and epilepsy parameters in unexpected ways. This is particularly critical in decisions regarding the strain of choice used in generating mice with targeted deletions of genes. Finally, we discuss the role of environment (at vendor and/or laboratory) and epigenetic factors for inter- and intrastrain differences and how such differences can affect the expression of seizures and the animals’ performance in behavioral tests that often accompany acute and chronic seizure testing.

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Section: Role Of Sex For Inter- and Intrastrain Differencesmentioning

confidence: 99%

The relevance of inter- and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy

Löscher¹,

Ferland

Ferraro

2017

Epilepsy & Behavior

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“…2006). It is likely that, at least in some cases, the neuroprotective effects of T are largely due to the conversion of T to E 2 by the enzyme aromatase (Pereno & Beltramino 2009; Pereno et al. 2010).…”

Section: Introductionmentioning

confidence: 99%

“…The active, supportive role of sex steroid hormones is echoed in the fact that several hormonesensitive brain areas regress in response to hormone withdrawal (Cooke et al 1999;Panzica et al 2001;Johansen et al 2004;MacLusky et al 2006). It is likely that, at least in some cases, the neuroprotective effects of T are largely due to the conversion of T to E 2 by the enzyme aromatase (Pereno & Beltramino 2009;Pereno et al 2010). Given the clinical ramifications of sex steroid hormone-mediated neuroprotection, there is a significant need for animal models to study this phenomenon, especially in species that undergo substantial neurodegeneration in response to the withdrawal of circulating hormones.…”

Section: Introductionmentioning

confidence: 99%

Cell death and the song control system: A model for how sex steroid hormones regulate naturally-occurring neurodegeneration

Thompson

2011

Development, Growth &Amp; Differentiation

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The production, learning, and perception of song in songbirds are regulated by a series of discrete brain nuclei known as the song control system. In most songbird species, the song control system is sexually dimorphic, and these dimorphisms become more robust after birds have hatched. In seasonally breeding songbirds, the song control system grows and regresses depending upon breeding context. The development and seasonal plasticity of the song control system are dependent upon neurodegenerative processes, which can be ameliorated, at least in part, by circulating sex steroid hormones. I will describe two areas of song control system research that have provided important information about how hormonal control of cell death contributes to the shaping of behaviorally-relevant brain circuits. First, sexual dimorphism in the zebra finch song control system is robust and emerges partially due to substantial regression of female song control system nuclei during development. Second, in seasonally-breeding songbirds, the song control system regresses as birds transition from breeding to non-breeding conditions. In a controlled laboratory setting where hormones can be acutely withdrawn, these brain areas regress in only a matter of hours to days. Taken together, these results demonstrate that the study of cell death in the song control system provides an excellent opportunity for understanding how changes in circulating levels of sex steroids affect the degeneration of hormone-sensitive brain circuits.

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“…In women, the low risk of dementia can be explained by the protective effect of estrogen, which elicits an anti-inflammatory effect that decreases the damage caused by cytokine secretion; this hormone also functions against neurodegeneration. 20 , 29 , 42 , 46 , 48 , 53 , 57 In addition, surgery for a fracture induces sequential inflammatory processes. 24 , 54 , 58 Further studies should also be conducted to determine whether or not other aging processes, physical conditions, and inflammation mediate fractures and cognitive decline.…”

Section: Discussionmentioning

confidence: 99%

Fracture as an Independent Risk Factor of Dementia

et al. 2014

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Dementia is among various diseases affecting the elderly, who is also at a high risk for fractures. This study aimed to evaluate the association between fracture history and sequential risk of dementia in Taiwan.A retrospective cohort study was designed using the claims data of the entire insured residents covered by Taiwan's universal health insurance from 1998 to 2010. A total of 66,797 patients with fractures and 133,594 control subjects without fractures were matched in terms of age (±5 years), sex, and index year and then recruited. Fractures and dementia were defined in accordance with the International Classification of Diseases, 9th Revision, Clinical Modification. The influence of fractures on the risk of dementia was analyzed using a Cox proportional hazards model.After a 12-year follow-up period, 2775 and 3991 incident cases of dementia were reported in exposed and unexposed cohorts, respectively. The overall incidence rate of dementia in individuals with fractures was 41% higher than that in individuals without fractures (6.05 vs 4.30 per 1000 person-years) at an adjusted hazard ratio of 1.38 (95% confidence interval 1.32–1.45) after age, sex, urbanization, and individual disorders or comorbidities were adjusted. Considering fracture location, we found that patients with hip fractures were at a slightly high risk for dementia. The occurrence of multiple fractures at a single visit was also significantly associated with an increased risk of dementia.Fracture history is regarded as an independent risk factor of dementia in individuals aged ≥65 years, particularly those who suffered from multiple fractures and/or fractures located in the hip. Further studies are needed to support an independent role of fracture in dementia considering the clinical information and other comorbidities.

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Effect of sex differences and gonadal hormones on kainic acid-induced neurodegeneration in the bed nucleus of the stria terminalis of the rat

Cited by 5 publications

References 51 publications

The relevance of inter- and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy

The relevance of inter- and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy

Cell death and the song control system: A model for how sex steroid hormones regulate naturally-occurring neurodegeneration

Fracture as an Independent Risk Factor of Dementia

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