Effect of Serenoa repens, Lycopene, and Selenium on Proinflammatory Phenotype Activation: An In Vitro And In Vivo Comparison Study

Bonvissuto, G.; Minutoli, Letteria; Morgia, Giuseppe; Bitto, Alessandra; Polito, Francesca; Irrera, Natasha; Marini, Herbert; Squadrito, Francesco; Altavilla, Domenica

doi:10.1016/j.urology.2010.07.514

Cited by 36 publications

(35 citation statements)

References 26 publications

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“…The efficacy of this association was recently confirmed in an in vitro and in vivo comparison study performed on rats with partial bladder outlet obstruction: prostate pro-inflammatory phenotype, as well as hyperplasia, was reduced more efficiently than the single compounds (25).…”

Section: Discussionmentioning

confidence: 79%

Effects of Serenoa Repens, Selenium and Lycopene (Profluss®) on chronic inflammation associated with Benign Prostatic Hyperplasia: results of “FLOG” (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study

et al. 2013

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Objective: To evaluate the efficacy of Profluss® on prostatic chronic inflammation (PCI). Materials and Methods:We prospectively enrolled 168 subjects affected by LUTS due to bladder outlet obstruction submitted to 12 cores prostatic biopsy for suspected prostate cancer + 2 cores collected for PCI valuation. First group consisted of 108 subjects, with histological diagnosis of PCI associated with BPH and high grade PIN and/or ASAP, randomly assigned to 1:1 ratio to daily Profluss® (group I) for 6 months or to control group (group Ic). Second group consisted of 60 subjects, with histological diagnosis of BPH, randomly assigned to 1:1 ratio to daily Profluss® + α-blockers treatment (group II) for 3 months or to control group (group IIc). After 6 months first group underwent 24 cores prostatic re-biopsy + 2 cores for PCI while after 3 months second group underwent two-cores prostatic for PCI. Specimens were evaluated for changes in inflammation parameters and for density of T-cells (CD3, CD8), B-cells (CD20) and macrophages (CD68). Results: At follow-up there were statistical significant reductions of extension and grading of flogosis, mean values of CD20, CD3, CD68 and mean PSA value in group I compared to Ic, while extension and grading of flogosis in group II were inferior to IIc but not statistical significant. A statistically significant reduction in the density of CD20, CD3, CD68, CD8 was demonstrated in group II in respect to control IIc. Conclusions: Serenoa repens+Selenium+Lycopene may have an anti-inflammatory activity that could be of interest in the treatment of PCI in BPH and/or PIN/ASAP patients.

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Section: Discussionmentioning

confidence: 79%

Effects of Serenoa Repens, Selenium and Lycopene (Profluss®) on chronic inflammation associated with Benign Prostatic Hyperplasia: results of “FLOG” (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study

et al. 2013

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“…An important question is: what is the relevance of NFkB inhibition by carotenoid derivatives presented here, to the known effects of various carotenoids on this transcription system [34][35][36][37]. This question is pertinent not only with respect to the NFkB system but also to several additional cellular processes found to be modulated by oxidized carotenoid derivatives [42,73].…”

Section: Discussionmentioning

confidence: 91%

“…In recent years, the anti-inflammatory effect of carotenoids was demonstrated in several in vitro and in vivo experimental systems [34][35][36][37][38][39][40]. Pretreatment with lycopene attenuated the proinflammatory phenotype as shown by the inhibition of NFkB activity, particularly in combination with other phytonutrients [34,39,40].…”

Section: Introductionmentioning

confidence: 99%

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Carotenoid derivatives inhibit nuclear factor kappa B activity in bone and cancer cells by targeting key thiol groups

Linnewiel-Hermoni

Motro

Miller

et al. 2014

Free Radical Biology and Medicine

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“…Furthermore, it should be intensified the knowledge about the mechanisms of action of these phytotherapics, not only in vitro but also in animals and in humans [5][6].…”

mentioning

confidence: 99%

Phytotherapy in the Treatment of Benign Prostatic Hyperplasia (BPH): Between Evidence and Empiricism

Morgia¹

2012

Clinic Pharmacol Biopharm

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Effect of Serenoa repens, Lycopene, and Selenium on Proinflammatory Phenotype Activation: An In Vitro And In Vivo Comparison Study

Cited by 36 publications

References 26 publications

Effects of Serenoa Repens, Selenium and Lycopene (Profluss®) on chronic inflammation associated with Benign Prostatic Hyperplasia: results of “FLOG” (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study

Effects of Serenoa Repens, Selenium and Lycopene (Profluss®) on chronic inflammation associated with Benign Prostatic Hyperplasia: results of “FLOG” (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study

Carotenoid derivatives inhibit nuclear factor kappa B activity in bone and cancer cells by targeting key thiol groups

Phytotherapy in the Treatment of Benign Prostatic Hyperplasia (BPH): Between Evidence and Empiricism

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